Dr Cush: In the absence of great evidence and realizing that much of the early evidence for serious hepatotoxicity was in psoriasis patients in Scandanavia (ie heavy drinkers) I have 2 pieces of advice for my my patients on MTX: 1) Do not take the MTX with alcohol (no good reason for that one- mainly aesthetic) 2) Do not drink more than I do (3-4 glasses red wine/week) Arthur Weinstein