So the answer to how much is too much is "It depends". I allow 2-3 drinks per week and monitor LFTs. (The contribution of the guidelines paper was to document that LFTs are indeed associated with hepatic histologic changes in any given year (although there were frequent bumps in LFTs the dose of MTX was always adjusted when this happened). These recs were very different from the Roenigk (derm) papers which indicated that there was no correlation with transaminase levels [and they obtained labs on the day of the biopsy and never in between! Joel