Thanks Lenny. I didnt add this specifically because I have a follow article on the long term success of MTX and the lessons learned. My own (evidence and experience backed) approach to alcohol is to be very permissive and not restrictive. Clearly MTX should be avoided w/ Liver dz and EtOH abuse or liver dz. Otherwise, its ok to drink wine or other spirits w/ moderation in mind. Alcohol is a good antiinflammatory and world wide cultures that imbibe more than the US have no more problems than we do. Its ok to have that margarita or evening glass of merlot. I dont recommend to my patients that they take their 6 MTX pills every friday night with a can of Miller lite - that just seems wrong, but I dont know that it is.