Halliwell group has done an interesting as well as practical study, amid the plethora of target therapy of psoriatic disease.
While Leflunomide was known to be more transaminase provoking and with our experience with 10 mg leflunomide, I wonder whether one might avoid the same day combination dosing; since Mtx needs only one day a week, by using lower dose Leflunomide and avoid same day Mtx-Lef administration might not be a viable combination strategy to avoid some of the reported adverse effect.