Jack: Great to see you at RWCS 2023. Disclosure: I study how stress impacts autoimmune disease and am bringing a relevant diagnostic through the FDA.
That said, I agree that Stress is a reaction, and yet humans are wired differently in turns of rapidity, intensity and resolution of this response to the world (allostatic load). I refer to the autonomic nervous system (ANS) which impacts mood, behavior, etc. but also cardiovascular, endocrine and immune processing.
Consider immuno-autonomics and the following references:
1. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve – an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
2.Tracey KJ. The inflammatory reflex. Nature 2002;420:853-859.
3. Koopman FA, Stoof SP, Straub RH, van Maanen MA, Vervoordeldonk MJ, Tak PP. Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis. Mol Med 2011;17(9-10):937-948.
4. Straub RH. Stress in RA: a trigger of proinflammatory pathways? Nat Rev Rheumatol 2014:10(9):516-8.
Jack: Great to see you at RWCS 2023. Disclosure: I study how stress impacts autoimmune disease and am bringing a relevant diagnostic through the FDA.
That said, I agree that Stress is a reaction, and yet humans are wired differently in turns of rapidity, intensity and resolution of this response to the world (allostatic load). I refer to the autonomic nervous system (ANS) which impacts mood, behavior, etc. but also cardiovascular, endocrine and immune processing.
Consider immuno-autonomics and the following references:
1. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve – an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
2.Tracey KJ. The inflammatory reflex. Nature 2002;420:853-859.
3. Koopman FA, Stoof SP, Straub RH, van Maanen MA, Vervoordeldonk MJ, Tak PP. Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis. Mol Med 2011;17(9-10):937-948.
4. Straub RH. Stress in RA: a trigger of proinflammatory pathways? Nat Rev Rheumatol 2014:10(9):516-8.