I am more sensitive to methotrexate and CKD now. I lower the dose or discontinue it for anything with any GFR less than 60. I am more concerned with my elderly patients.. The alternative would be leflunomide which does not carry a contraindication with CKD.
I am more sensitive to methotrexate and CKD now. I lower the dose or discontinue it for anything with any GFR less than 60. I am more concerned with my elderly patients.. The alternative would be leflunomide which does not carry a contraindication with CKD.