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Charles - Agreed! there's clearly a channeling bias, those on vs. those not on acetaminophen - the groups had to be different. But, I might argue that incredibly large numbers may mitigate a channeling bias? This UK Clinical practice data set is gigantic- comparing 180,483 acetaminophen-users and 402,478 non-users.. Would the numbers alone make you think, well maybe there is some risk to acetaminophen use? I cant say that Im worried about my recommending it to elderly patients who need pain management.