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Digital Platforms and AI

2026 EULAR Press Release

EULAR works with the network of national organisations of People with Arthritis/Rheumatism in Europe (PARE) to ensure the voices of people with RMD are heard and have influence – creating powerful alliances that make a real difference. Artificial intelligence is another potential ally in that fight. At the EULAR 2026 Congress in London, work was presented from three PARE initiatives that showcase how digital tools can be used in treatment education and decision-making, and potentially avoid the use of general web searches to answer important questions.

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Count Your Telangiectasias (5.29.2026)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and missed quiz questions.

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Sjogren's on chalkboard

RepurpSS-II: Hydroxychloroquine plus Leflunomide in Sjögren's

Jack Cush, MD

A small, pilot, phase 2b trial has shown that the combination of leflunomide and hydroxychloroquine (LEF+HCQ) was effective and safe in treating patients with active Sjögren's disease.

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Epidemiology of Dry Eye Autoimmune Disease

Jack Cush, MD

Dry eye rates upwards of 20% were seen across nine common autoimmune diseases other than Sjögren's, most often in rheumatoid arthritis (39.3%) with Crohn's disease bringing up the rear (23.0%), according to Chi-Chin Sun, MD, PhD, of Chang Gung Memorial Hospital in Keelung, Taiwan, and colleagues.

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Prevention in Lupus and Therapeutic Evolution in Sjögren’s

Audrey Gibson, PA-C

The notion of intervening in autoimmune disease prior to the onset of irreversible tissue damage has evolved beyond a theoretical framework; it is presently undergoing empirical evaluation. Recent discussions on incomplete lupus and the SMILE trial, alongside advances in Sjögren’s therapeutics, highlight both the promise and complexity of prevention and precision treatment in systemic autoimmunity.

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ANA Pollution (2.06.2026)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and regulatory news from this past week on RheumNow.com

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#EULAR2026 Please find my video interview with Prof Xavier Mariette, the presenting author of Abstract OP0126: Efficacy and Safety of Ianalumab in #Sjogren disease #SjD @RheumNow https://t.co/NEyBOD6Qj2 https://t.co/Zn1fH6eu39

Links:

Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#EULAR2026 OP028 In 16 patients with AID (SSc,IIM, RA, IgG4,SjD, Grave’s), CD3xBCMA BiTE, Teclistamab was effective in 15/16. Duration of GC & DMARD-free was 11 mths. 2/16 need retreatment. All had low IgG and needed IVIG. Need long-term safety data & comparative study @RheumNow https://t.co/97MUPnXRua

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)

#EULAR2026 OP0126 Long-term extension study up to 108 weeks: Ianalumab demonstrated sustained efficacy (change in ESSDAI) including those who switched from PBO to IAN in #Sjogren. IAN improved most domains apart from lungs, MSK & Haem - important to note @RheumNow #EULARBest https://t.co/x1d4G1s0jw

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#EULAR2025 OP0127 Still trying to get my head around the flat line PBO response. In Sjogren pts with ESSDAI=>5, a Phase 3 RCT of Telitacicept (BAFF/APRIL-i) in China met all endpoints. ESSPRI improved too! Could be because strict concom DMARD inc. GC protocol @RheumNow https://t.co/FEhXfNPvfG

Links:

Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
RepurpSS-II: Hydroxychloroquine plus Leflunomide in Sjögren's A small pilot, phase 2b trial has shown that the combination of leflunomide and hydroxychloroquine (LEF+HCQ) was effective and safe in treating patients with active Sjögren's disease. https://t.co/eeyhso0WJ6 https://t.co/ZGWOOtf92E

Links:

Dr. John Cush RheumNow ( View Tweet)
RepurpSS-II: Hydroxychloroquine plus Leflunomide in Sjögren's A small pilot, phase 2b trial has shown that the combination of leflunomide and hydroxychloroquine (LEF+HCQ) was effective and safe in treating patients with active Sjögren's disease. https://t.co/tyd1efUtca https://t.co/zcY7RyX8SZ

Links:

Dr. John Cush RheumNow ( View Tweet)
Chinese study of 371 pts w/ Autoimmune hepatitis (AIH) - extrahepatic autoimmune diseases (EADs) seen in 24% -Sjogren’s & autoimmune thyroid dz (9% each). ANA+ independently assoc w/ EADs (OR 2) https://t.co/NVz8MWbJch https://t.co/tjCzaDcUFI

Links:

Dr. John Cush RheumNow ( View Tweet)
Epidemiology of Dry Eye Autoimmune Disease Rates upwards of 20% were seen across nine common autoimmune diseases other than Sjögren's, most often in rheumatoid arthritis (39.3%) with Crohn's disease bringing up the rear (23.0%), according to Chi-Chin Sun, MD, PhD, of Chang Gung https://t.co/Z8ZBGmqT93
Dr. John Cush RheumNow ( View Tweet)
A month ago the FDA Granted Breakthrough Designation to Ianalumab for Sjögren Disease . The drug targets BAFF and depletes B cells. Two recent positive RCTs (NEPTUNUS-1, NEPTUNUS-2). Novartis expects a regulatory decision in early 2026 https://t.co/PXVjGG1Cmd https://t.co/0s5livw1bg

Links:

Dr. John Cush RheumNow ( View Tweet)
Epidemiology of Dry Eye Autoimmune Disease Rates upwards of 20% were seen across nine common autoimmune diseases other than Sjögren's, most often in rheumatoid arthritis (39.3%) with Crohn's disease bringing up the rear (23.0%), according to Chi-Chin Sun, MD, PhD, of Chang Gung https://t.co/lnacSUlrI8
Dr. John Cush RheumNow ( View Tweet)
Prevention in Lupus and Therapeutic Evolution in Sjögren’s explores the proactive approach in autoimmune diseases, moving from theory to empirical evaluation. Recent discussions on incomplete lupus and the SMILE trial, along with advancements in Sjögren’s treatments, underscore https://t.co/KY9nHnpkxk
Dr. John Cush RheumNow ( View Tweet)
FDA has announced "Breakthrough Designation" for 3 drugs + 1 test being developed: ** Biogen: litifilimab (targets dendritic cells) for cutaneous lupus ** Novartis: Ianalumab (BAFF blockade) for Sjogrens ** J&J: Nipocaiimab (FcRn) for Sjogrens ** Encarta: pocket Lyme test https://t.co/RMKg14rejq
Dr. John Cush RheumNow ( View Tweet)
FDA has announced "Breakthrough Designation" for 3 drugs + 1 test being developed: ** Biogen: litifilimab (targets dendritic cells) for cutaneous lupus ** Novartis: Ianalumab (BAFF blockade) for Sjogrens ** J&J: Nipocaiimab (FcRn) for Sjogrens ** Encarta: pocket Lyme test https://t.co/zODOTWyqP8
Dr. John Cush RheumNow ( View Tweet)
B Cells at the Brink in Sjögren Disease The current issue of Arthritis & Rheumatology reviews the current understanding of the immunopathogenesis of Sjögren disease (SjD) and how this understanding has informed drug development for this systemic autoimmune disorder. https://t.co/zI7lQ5N54o
Dr. John Cush RheumNow ( View Tweet)
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