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ACR24: Rheumatology Roundup

d Jack Cush, MD

Join Drs. Jack Cush and Artie Kavanaugh as they review 15+ presentations and abstracts from the 2024 ACR Convergence meeting in Washington, DC.

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ICYMI: Taking CAR-T for a Test Drive

d Michael Putman, MD, MSCI

When the ACR Convergence 2024 abstract site went live, the first query I typed into the search bar was, “CAR-T.” I consider myself a CAR-T skeptic and would be surprised if the magical results from this NEJM case series replicate at scale, but it seems likely that CAR-T will revolutionize the care for (some) patients with rheumatic diseases.

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Ozempic will change rheumatology

d David Liew, FRACP

Many of our diseases are made worse by obesity, notably rheumatoid arthritis, psoriatic arthritis, and osteoarthritis. Much of the refractory pain and suffering from these conditions might be attributable to obesity, so active questions will be raised about how GLP-1 agonists can influence the diseases we treat.

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Off-Label Use of JAK Inhibitors in Orphan Diseases and Other Conditions?

d Janet Pope, MD, MPH, FRCPC

When should you consider off-label use of JAKi?

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Novel TYK2 inhibitor Zasocitinib

d Brian Jaros, MD

Similar to JAKs, TYK2 is an important mediator of innate and adaptive immune activation. Unlike JAKs, however, TYK2 is thought to play a minimal role in other pathways, such as metabolic and hematopoietic axes. Therefore, it is hypothesized that TYK2-targeted agents could be effective in rheumatic disease, with a potential for less off-target adverse effects. Zasocitinib is a new, oral TYK2 inhibitor generated using artificial intelligence-assisted compound design.

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Study of 16,598 CAD pts showed in pts w/ normal hsCRP<2mg/L, increasing SUA didnt predict CV/MACE events. But if the hsCRP≥2 mg/L, increasing urate(SUA)was signif. assoc w/ increased MACE. Each 1mg incr in SUA yielded an 11% increase in MACE (adj p < 0.001)… https://t.co/9ehtOcoeBK https://t.co/t9IWQ8WUvY
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Autoantibodies, found in over half of adult and paediatric patients with idiopathic inflammatory myopathies (IIMs), these correlate with clinical phenotypes, aiding in classification and prognosis. https://t.co/ZRXqtEec6s https://t.co/jkUe9bRlmU

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Why should rheumatologists care about aging? As a herald to what was to come in Washington, the publication of the Lancet Rheumatology series on aging coming just days before #ACR24 set the stage for the “grey tsunami” of geriatric rheumatology that was to follow.… https://t.co/XfB7ykV0Xs https://t.co/51Cjz3EGyn
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RA-ILD in the Spotlight at #ACR24 Over the past 5 years, there has been growing interest in RA-ILD due to its relative prevalence and severity. This seems to be one of the few RA outcomes not improving much, even with the advent of expanded treatment options.… https://t.co/MIPXW9EgVa https://t.co/kX0hDq8NTH
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The Case for JAKi in PMR Dr. David Liew abstract 0858, Baricitinib in Early Polymyalgia Rheumatica (BACHELOR Study), presented at #ACR24. https://t.co/NLF75PuMOb https://t.co/FpUUdbtrwf

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What Lies Beneath: Understanding Nailfold Capillaroscopy Capillaroscopy is a non-invasive imaging technique used for the in vivo assessment of the microcirculation. It can be performed using various optical instruments, but only the dermatoscope and videocapillaroscope have… https://t.co/JK9EvuxWEV https://t.co/77AcwfKIzE
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Cyclophosphomide vs Mycophenolate vs Tacrolimus in Lupus Nephritis Dr. Mike Putman discusses abstract 0670, presented at #ACR24. https://t.co/QiWdioliDi https://t.co/DPRA58vyUn

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ANA+ and no Autoimmune Disease? Check the liver Dr. Janet Pope discusses abstract 0627, presented at #ACR24. https://t.co/4HV2kqjibL https://t.co/kmVcvUZtRQ

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Dreaming of Relief: The Importance of Sleep in Lupus and Rheumatoid Arthritis Sleep is crucial for managing inflammation and health. In rheumatic diseases like lupus and RA, disrupted sleep is common and can worsen symptoms and disease progression. Experts stress the importance… https://t.co/u3DmSdaoVN https://t.co/ncMX3uhOMw
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#ACR Best 2024 - Day 4 Although the last day of #ACR24 was but a half day - it was chock full of gems, many coming from the late breaking abstracts presented today. As chosen by the RheumNow faculty, here are some highlight presentations you need to know about.… https://t.co/GseDW1ZfkL https://t.co/35aJs0yG8i
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The Psoriatic March: PsA before PsO https://t.co/lRCrzdKX7Z https://t.co/eabYe3GXrM

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Worried about CV Risk and JAKi? What about the Steroids? Dr. David Liew discusses abstracts 1981 and 2673, presented at #ACR24 https://t.co/OkMgIqxl2A https://t.co/1DVapGcWUn

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#ACR24: What I learned in Sjogren's, Takayasu's and CAR-T Dr. Janet Pope reviews abstract 2527 and abstract 1696. https://t.co/rrrGnOhfIV https://t.co/Ht1UTtYOLI

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What's New in Relapsing Polychondritis? Dr. Bella Mehta discusses abstract 2649 presented at #ACR24. https://t.co/4ibGOFzTAG https://t.co/fnvp1m1nS8

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A useful urinary biomarker for lupus nephritis Dr. Andrea Fava discusses plenary abstract 1642, presented at #ACR24 https://t.co/5kFXUn3xlF https://t.co/mWTX9SbDGm

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