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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.
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A single center analysis of systemic lupus erythematosus (SLE) patients found symptomatic osteonecrosis (ON) in nearly 10%.
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Lancet Rheumatology has published a cohort analysis showing that a small but significant subset of children presenting with arthralgia or arthritis may have a pediatric malignancy.
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Chung et al have published the 2021 treatment guielines for the management of antineutrophil cytoplasmic antibody–associated vasculitis, including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. These guidelines are put forth by the ACR and the Vasculitis Foundation as benchmark guidance to assist health care professionals in managing AAV.
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Gradual withdrawal of glucocorticoids was successful among patients with systemic lupus erythematosus (SLE) after 2 years of clinically quiescent disease, without an increased likelihood of flares, Canadian researchers reported.
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Hydroxychloroquine (HCQ) is one of the safest meds used in rheumatology, but there is new claims data suggesting a small increase in the risk of malformations associated with first-trimester HCQ use.
Dr. John Cush
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Of 100 newly diagnosed #RA patients, Foot Involvement was the 1st manifestation in 29%. Pattern: 59% w/ forefoot involvement, 27% hindfoot and 14% midfoot. Pts were 58-63% RF+/CCP+. https://t.co/OGS2Fzfgg3 https://t.co/AKCj4pipYG
Matthew Sparks, MD, FASN, FAHA
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Very cool to see #RheumMadness in @ACRheum 🔥
#NephMadness —> #RheumMadness a “joint” venture
Impressive work by @DavidLeverenz and entire team @LisaCriscione @GuyKatzMD @didemsayginmd @Allen06440733
RheumMadness: An Educational Tournament
https://t.co/hHpm93C0yT https://t.co/ZPYxG6NUrl
Dr. John Cush
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ACR/Vasculitis Foundation 2021 Guidelines for ANCA–Associated Vasculitis
Chung et al have published the 2021 treatment guidelines for the management of antineutrophil cytoplasmic antibody–AAV, including GPA, MPA, and EGPA.
https://t.co/234OQ7klRd https://t.co/33sWq1U55T
Dr. John Cush
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Ann Int Med: 185 Hospitalized COVID-19 pts were treated with either PBO remdesivir or HCQ. Neither remdesivir nor HCQ affected viral clearance, Sxs duration, mortality or need for mechanical ventilation. https://t.co/NEFABDD4bK
Dr. John Cush
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Todays NEJM: Ruxolitinib effective in glucocorticoid-refractory Chronic Graft-versus-Host Dz. Phase 3, 329 pts; wk 24 responses better w/ RUX (50 vs 26%; P<0.001). Important? as there is phase 2 data showing JAK efficacy in scleroderma https://t.co/ygLevqfuMW
Dr. John Cush
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In 2016, 552,230 RA adults were hospitalized -1120 for influenza, 590 H zoster, & 785 for S. pneumoniae. These infections constituted 0.5% of RA hospitalizations at a cost of $124 million & 13,750 hosp stay days. https://t.co/7vtsWafGvv
Dr. John Cush
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2020 saw record numbers of drug overdose deaths (93,331) a big increase (29.4%) over 2019, according to CDC & Natl Center Health Statistics (NCHS). Overdose deaths 69,710 primarily fentanyl, Rx pain meds and cocaine https://t.co/K9GlWAeALS
Dr. John Cush
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Telehealth has declined but still much higher than pre-pandemic. CMS is proposing to extend Medicare coverage of certain telehealth services until the end of 2023. A -3.75% payment adjustment has been proposed & will be debated https://t.co/ETK74d9uGT
Dr. John Cush
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Metanalysis shows that Ustekinumab (effective in IBD) may also control skin and joint extra-intestinal manifestations. Despite no effect on spondylitis, UST was effective at PSO, PsA, pyoderma gangrenosum, E nodosum stomatitis and uveitis https://t.co/NPxJdYUM7I
Dr. John Cush
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Systematic review of muscle relaxants use in nonspecific low back pain shows uncertain, small, but not clinically important reductions in pain in the 1st 2weeks. Muscle relaxants are 3rd most common Rx for LBP (30 mill Rx in 2016)(49 trials >6505 pts) https://t.co/zN5rvBF1HO
Dr. John Cush
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Norwegian pre-pregnancy registry studied 274 axial SpA and 317 RA women. Longer time to pregnancy (TTP) seen in 21% (32% TTP >12 mos). Longer TTP associated with older age, nulliparity, and longer disease duration. https://t.co/kT7fqnhTkw https://t.co/8qC1N2K7vI
Dr. John Cush
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NHANES survey study shows adult psoriasis in the US was 3.0% (7.5 million adults). Psoriasis was most common in non-Hispanic White individuals, and the prevalence of psoriasis has not significantly changed since 2003 in the US. https://t.co/3yrlPu1GGi
Dr. John Cush
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Rare Myocarditis Risk following COVID-19 Vaccine
https://t.co/Q9QGhTTKvC https://t.co/dTOR9sZ3iP
Dr. John Cush
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FDA & CDC joint statement: Those who are "fully vaccinated do not need a booster shot at this time".
People who are not vaccinated remain at risk. Virtually all COVID-19 hospitalizations and deaths are among those who are unvaccinated. https://t.co/miqEJE4wgC
