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Frequency and Features of CPPD
An international cohort study of patients with calcium pyrophosphate deposition (CPPD) disease, i.e., recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS) identifies both acute and chronic inflammatory phenotypes, each with distinctive clinical and imaging diagnostic features.
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Decline in Physician Trust During the COVID-19 Pandemic
JAMA reports that following the COVID-19 pandemic US adults trust in physicians and hospitals decreased, and was associated with lower odds of COVID vaccination.
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Review of Calcium Pyrophosphate Deposition Disease
Lancet Rheumatology has published a review of Calcium pyrophosphate deposition (CPPD) disease - a chronic inflammatory and degenerative crystal arthropathy that increases with aging.
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NSAIDs Used Despite Contraindications
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EurekAlert!
Osteoarthritis affects 600 million people worldwide, making it a leading cause of disability.
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Pain Reduction with Methotrexate in Knee Osteoarthritis
The Annals of Internal Medicine reports that oral, low dose, weekly methotrexate significantly reduced knee osteoarthritis (KOA) pain, stiffness, and function in a randomized controlled trial.
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Arthritis drugs may relieve long COVID lung symptoms
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EurekAlert!
University of Virginia School of Medicine researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs.
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Arthritis drugs may relieve long COVID lung symptoms
University of Virginia SOM researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs.
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Dr. John Cush RheumNow ( View Tweet)
US Childrens Hosp Admission database finds 8588 kids w/ SLE & ≥ 1 hospitalization; 13% for infections, w/ Bacterial pneumonia most common. cSLE In-hospital mortality in 0.4%, but 2% for infection. Highest mortality w/ PJP (21%), fungal infx (21%) https://t.co/fmyRXagCcD https://t.co/yXDMFYhhdP
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Full read review of tendinopathies - triggers (mechanical, intrinsic, extrinsic), biology, biomechanics & repair. Despite multivariable biologic disruptions, tendinopathies is mostly restricted to symptomatic therapy. https://t.co/h2D3fbUNVO https://t.co/2rmw6E0F6Z
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Cohorts of 100 compared PsO/PsA pts to controls. Psoriatic pts had significantly more cases of polyneuropathy than controls (RR ~20), but the significance was lost when corrected for frequent comorbidities that cause neuropathy https://t.co/ujPlgmISUc https://t.co/aNLaJMDhvM
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CHECK: a prospective cohort study shows that Femoroacetabular impingement syndrome in is strongly associated with the development of radiographic hip OA (RHOA) within 10-yrs (OR 6.85 for incident RHOA and OR 47.82 for end-stage RHOA) https://t.co/Kt0bsIdpnS https://t.co/mSGRbQV4vI
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TRUST: 10 Yr Japanese study of tacrolimus in 1355 SLE nephritis pts; half on TAC x 10yrs. TAC use assoc w/ signif reduction corticosteroid use (~16 mg/d @4wks to 7.2 mg/d @ 1Yr(P < 0.001). 9.7% w/ serious AEs. https://t.co/PsfCVZF4tk https://t.co/l3HkTRc4oC
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Elder adult Cohort study of 2413 women & 792 men w/ hip BMD-defined osteoporosis based on CT scans, shows 30% of women & 34% of men had hip Fx. Rx w/ alendronate (34%F; 24% M) signif lowered Fx rates (aOR 0.26 and 0.21, respectively) = no sex difference https://t.co/briuZAYVKx https://t.co/xrZ12TmMvM
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Literature review - Glucocorticoid use in elderly to be problematic. GC use may be assoc w/ remission, but GC increases AE rates, & there is difficulty w/ GC discontinuation. Goal: D/C GC early, but some may require for up to yrs to control Dz activity https://t.co/6liN0mubIv https://t.co/PiGKGSYrof
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New Classification Criteria for Juvenile Axial Spondyloarthritis
An expert panel has published new and validated classification criteria for axial disease in children with juvenile spondyloarthritis (SpA; AxJSpA).
https://t.co/kxtHlEk5XG https://t.co/jKAp9W5Di1
Dr. John Cush RheumNow ( View Tweet)
In the UK, estimated cost of hardardous NSAID use is £31.43million (pounds) (£9.28m to £67.11m) over 10 yrs. High risk = Elderly >65y without gastroprotection, pts on anticoagulants; & Pts w/ heart failure, chronic kidney Dz , or Hx of peptic ulcer. https://t.co/bPXnQbQnNV https://t.co/aDLGHjLmhB
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Harris poll of 1286 #PsA pts (52% female) shows gender differences in perception. Women had different presenting Sxs, more joint tenderness, skin PSO, and enthesitis, and greater impact on well-being. Treating female PsA is different! https://t.co/H3PQkKCg9n https://t.co/FmwhgkVJ7J
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Polypharmacy Doubled in 20 Years. Polypharmacy (5+ Rx last month) went from 24% in 2000 to > 40% in 2020 https://t.co/2czI4DxlVm https://t.co/VAZkbxKrJP
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FIRST registry of 1424 #RA pts found 732 achieving HAQ-DI <0.5 & 454 w/ pain VAS <4/10. Achieiing LDA in 1st 6mos predicted by seropositivity & JAKi use. Less likely were: older, failin ≥ 2 b/tsDMARDs, hi baseline HAQ& steroid use (not comorbidities) https://t.co/7y0uMV414j https://t.co/6aLPTzf5fm
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Location, Location, Location (7.26.2024)
Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow. Location matters; Geo-rheumatology?
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Dr. John Cush RheumNow ( View Tweet)