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Stopping Biologics Before Joint Surgery: Is Earlier Better?

d RheumNow

Withholding intravenous abatacept (Orencia) for longer than a month before hip or knee arthroplasty among patients with rheumatoid arthritis (RA) did not lower the risk for postoperative infection, a retrospective claims-based analysis found.

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Mortality and Hospitalization with Pulmonary Hypertension in Systemic Sclerosis

d Jack Cush, MD

PHAROS is a prospective cohort studying the natural history of pulmonary hypertension (PH) in systemic sclerosis (SSc). They have shown that risk factors for poor outcomes in this cohort included male sex, DLCO < 50%, exercise oxygen desaturation, and pericardial effusions. 

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Noninfectious Proximal Aortitis Needs Serial Follow-ups

d Jack Cush, MD

A Cleveland Clinic review of patients undergoing thoracic aortic surgery (1996‐2012) identified 196 patients with histopathology‐proven non‐infectious aortitis.

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No Added Benefit to MRI-Guided Therapy in Rheumatoid Arthritis

d Jack Cush, MD

A treat-to-target (T2T) strategy to manage rheumatoid arthritis hinges on clinical metrics to optimize therapy. But investigators from Denmark have shown that using magnetic resonance imaging–guided T2T failed to improve disease activity remission rates or reduce radiographic progression.

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Dr Aryeh Fischer on ILD increasing #RWCS2019 https://t.co/euvky7H3Bs
Dr. John Cush RheumNow ( View Tweet)
Good morning from #RWCS2019! Year in Review #1: HCQ doesn't work for hand OA, so stop using it! Jack Cush @RheumNow has talked about this multiple times on his podcast. I'd say the same for Sjogrens (see my podcast on JOQUER trial), but that's more controversial. https://t.co/fmb2bfVhg0
Mike Putman EBRheum ( View Tweet)
Analysis of a large Pediatric hospital database and 5679 SLE admissions shows that 12.4% had Pericardial Effusion (PCE) at entry. PCE was assoc w/ 2.5 higherrisk of In-hospital mortality(p 0.027) and 1.5 time more 30Day readmissions (p 0.001). https://t.co/XS6FEGfdH5

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Dr. John Cush RheumNow ( View Tweet)

927 Lupus registry study shows that use of combined hormonal contraceptives was low (8%) and nearly half (55%) took place in the setting of possible contraindication such as aPL (52%), HTN (34%), migraine with aura (22%). More study and info is needed https://t.co/yTCKbRTp2m

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Dr. John Cush RheumNow ( View Tweet)

RCT of 559 patients undergoing hip replacement shows that postoperative use of paracetamol plus ibuprofen or ibuprofen alone significantly reduced morphine consumption. https://t.co/JbnkvBzibC

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Dr. John Cush RheumNow ( View Tweet)

JBMR reports that women with single & multiple fractures (hip, spine, ribs) strongly negatively impacts the HRQL of older people over a prolonged period, and that they may not recover their prefracture QOL. https://t.co/1udPUiyCc0

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Dr. John Cush RheumNow ( View Tweet)

Small study of 25 pregnancies in RA compared those who continued biologics till conception vs those who stopped before conception. Continuing biologics till conception lead to a significantly shorter time to pregnancy. https://t.co/NjhMDbQVux

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Dr. John Cush RheumNow ( View Tweet)

Dr Anne Stevens at RWCS. Many dysregulated paths contribute to fibrosis in disease. #RWCS2019 https://t.co/dCXjoge0yL
Dr. John Cush RheumNow ( View Tweet)
Dr Anne Stevens at RWCS. Pathways to Fibrosis. #RWCS2019 https://t.co/gTYWWrxY81
Dr. John Cush RheumNow ( View Tweet)
Dr Paul Emery at RWCS. RA without xray erosions- 45% have ultrasound erosions #RWCS2019 https://t.co/MlOUaMTgfd
Dr. John Cush RheumNow ( View Tweet)
Dr Paul Emery at RWCS. #RWCS2019 https://t.co/MFqjLVzpDa
Dr. John Cush RheumNow ( View Tweet)
Dr Aretha Fischer on how to tx ILD. #RWCS2019 https://t.co/vZhX25NhFF
Dr. John Cush RheumNow ( View Tweet)
Dr Aretha Fischer on ILD. #RWCS2019 https://t.co/YAyXapxr8C
Dr. John Cush RheumNow ( View Tweet)
The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 22-24 2019 Great Venue =Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

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Dr. John Cush RheumNow ( View Tweet)

Genetic study using Mendelian randomization methods in a large UK biobank shows that whereas serum Uric acid has no association with eGFR level nor CKD risk, sUA does show a significant risk of #Gout. https://t.co/YRiVuOKof4

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Dr. John Cush RheumNow ( View Tweet)

In a mouse model of Pso/SpA/IBD the administration of IL-23 was associated with specific microbiome changes that correlated with disease activity https://t.co/wWjVNkvOfz

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Dr. John Cush RheumNow ( View Tweet)

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