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Differing Effects of Smoking and HLA-DRB1 in Seropositive Rheumatoids

d Jack Cush, MD

Analyses from the Swedish EIRA incident rheumatoid arthritis cohort study shows that smoking and HLA-DRB1 exert differential effects on serologically defined RA subsets - but that the strongest influence was seen in double positive (CCP+, RF+) individuals.

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SEAM-PsA Study - Does Monotherapy MTX Win Despite Losing to Etanercept in Psoriatic Arthritis?

d Jack Cush, MD

The SEAM-PsA study examined the efficacy of methotrexate monotherapy, etanercept monotherapy or the combination of MTX and ETN in psoriatic arthritis patients, and found that ETN monotherapy was equivalent to combination therapy - and that both were superior to MTX alone in clinical (ACR and MDA) and radiographic responses.

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Ten Contemporary Challenges Facing Lupus Treatment

d Jack Cush, MD

A group of French researchers have pooled their interests to identify the challenges ahead in the management of patients with systemic lupus erythematosus (SLE). 

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HHS Issues New EHR Record Sharing Rule

d Jack Cush, MD

WASHINGTON -- Patients would have access to their electronic health records free of charge and would be able to transfer them more easily from one provider to another under rules proposed Monday by the Department of Health and Human Services (HHS).

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RheumNow Podcast – Downside of Lupus (2.9.19)

d Jack Cush, MD

Dr. Jack Cush reviews this past week's news and reports from RheumNow.com:

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Guidelines Recommend Against Acromioplasty

d Jack Cush, MD

Subacromial pain iacounts for up to 70% of shoulder pain. Patients may be diagnosed with subacromial pain syndrome (SAPS), shoulder impingement, or rotator cuff disease and often end up in surgery. 

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To all Rheumatologists & others: T or F I am reasonably familiar with the entity-Clonal Heamatopoesis of Indeterminate Potential (CHIP) (getting ready for my Highlights of Basic & Clinical Immunology series! )@RheumNow @RheumatologyUK @join_IAS @autoimmunitymd @AutoimmuneList

Leonard Calabrese LCalabreseDO ( View Tweet)

Is the Serious infection (SIE) risk different between TCZ and TNFi? Not when used after failing 1 TNFi; But for biologic initiators, SIE risk was higher in TCZ compared to TNFi or ABA (based on claims data from 16074 TCZ matched to 33109 TNFi initiators https://t.co/kT9R04pBrz

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Dr. John Cush RheumNow ( View Tweet)

The CDC says the flu season is peaking and far from over. https://t.co/XUqNQk86Xz

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Dr. John Cush RheumNow ( View Tweet)

Cytokine profiles in lupus do not differ based on the Autoantibody status; hence the same in those positive for SSA/SSB or Sm/RNP or APL or multiple. However ANA negative Lupus have sign lower levels of IFNγ, TNFα, IL12/IL23p40, etc. https://t.co/jiEBPKbtxt

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Dr. John Cush RheumNow ( View Tweet)

Read the Brazilian Societyof Rheum guidelines on the use of nailfold capillaroscopy. Indications: Raynauds; Dermatomyositis; MCTD; Systemic sclerosis. NFC can be done by stereomicroscope, videocapillaroscope, dermatoscope, or ophthalmoscope. https://t.co/sTAddqh376

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Dr. John Cush RheumNow ( View Tweet)

Medicine info sheets used by Rheus exceeds 8th grade reading. Comprehension was low w/ correct answers by 9/21 pts for adalimumab, 7/11 for MTX, 6/28 NSAIDs, 13/24 abatacept MIS.. Simpler, shorter MIS with pictures and infographics are needed. https://t.co/ZPVX6wQVwR

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Dr. John Cush RheumNow ( View Tweet)

Priorities differ between Docs and Patients with Ulcerative colitis - Pts need to discuss managing Sxs/problems, inflammation, cancer risk. GI-MDs top priorities were managing Sxs and side effects from meds. https://t.co/m4eUa1QFVq

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Dr. John Cush RheumNow ( View Tweet)

2015–2017, 2.8% of persons in the USA had an injury (in the past 3 months) that lead to medical attention. Rates highest n the 10-19 yr. and >65 yrs age groups. https://t.co/PdyluqSymL

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Dr. John Cush RheumNow ( View Tweet)

It is also poor prognosis for the patient if Rheum and ID are standing next to each other in the room https://t.co/BQ6tGwH1Pe

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k dao KDAO2011 ( View Tweet)

Very alarming!!! I found a few of my patients have undetectable rubeola Ab. Are you checking measles titers in your immunosuppressed patients? @rheumnow Measles | Cases and Outbreaks | CDC https://t.co/BI1qNnja5M via @CDCgov

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k dao KDAO2011 ( View Tweet)

Check out a weeks worth of QD Clinic Podcasts - Week 5. Case discussions from the Rheumatology clinic. Available in iTunes or on SoundCloud https://t.co/bYc4Vi3J2O

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Dr. John Cush RheumNow ( View Tweet)

The RHeumNow Podcast is up! Alot on lupus this time. View here: https://t.co/fIq9qOFRW6 or listen to podcast on iTunes, Apple Car Play Podcasts or on SoundCloud https://t.co/wtmkKEsqCX

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Dr. John Cush RheumNow ( View Tweet)

NEJM: Oral and genital ulcers in Behcets disease https://t.co/wrY8m3RDGc

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Dr. John Cush RheumNow ( View Tweet)

Study of 3209 incident lupus pts in Sweden shows lung dz to be 6 fold more common than controls (IR 14/1000 Pt Yrs), including a 19 fold higher risk of interstitial lung disease. https://t.co/olLejMXv6j

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Dr. John Cush RheumNow ( View Tweet)

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