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RheumNow Podcast – A Grand New Year (1.4.19)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journals for the beginning of 2019. All from RheumNow.com.

Best wishes for a charmed 2019! My advice: 1. Just show up. 2. If you can, then you must do. 3. Live each day as if it twas your 1st day/last day/make or break day. 4. Teach.

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2018 Rheumatology Year In Review

d Jack Cush, MD

This annual appraisal of hallmark moments, news and research articles from 2018 are gleaned from that published in RheumNow during the last year and filtered by other news sources and literature review.  The top 10 list herein is rooted in what rheumatologists should know and what will likel

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Uncertain Long Term Efficacy in Trials of Knee Osteoarthritis

d Jack Cush, MD

A systematic review and network meta-analysis of 47 randomized clinical trials in knee osteoarthritis finds uncertainty around estimates of effect size for pain scores thereby casting uncertainty over the long-term efficacy of medications for knee osteoarthritis.

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Sleep Apnea Increases Gout Risk

d Jack Cush, MD

Both Gout and obstructive sleep apnea (OSA) comingle with a wide range of serious comorbidities. A matched retrospective cohort study from the UK Clinical Practice Research database shows those with OSA are at a higher risk of developing gout.

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Severe Cutaneous Sarcoid Treated with Tofacitinib

d Jack Cush, MD

Researchers from Yale have taken a novel approach and shown benefits when using tofacitinib in severe cutaneous sarcoidosis.

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Best of 2018: The Safety of Paternal Exposure to DMARDs and Biologics

d Jack Cush, MD

Pregnancy and drug safety is a complex issue, often with limited information about maternal drug exposure on the offspring. Greater uncertainty exists when considering whether paternal exposure may also influence fetal outcomes.

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Chronic Urticaria associated with a 23% higher risk of osteoporosis, irrespective of steroid use. Population study from Israel compared 11,944 Chr urticaria w/ 59,829 controls. (HR = 1.23, 95% CI 1.10–1.37, p <0.001) https://t.co/eSq4BPV2J4

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Analysis of pegloticase clinical trial data shows that tophus resolution was achieved by 69.6% of 23 responders, 27.9% of 43 nonresponders, and 14.3% of 21 patients who received placebo. Resolution time = 9.9 mos. https://t.co/4Pu16t3BV8

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Case series compared 247 pregnancies in IgA Vasculitis patients vs 556 control pregnancies showing IgA Vasculitis had no effect on fertility and did not induce flares. But IgAV had more spont. abortions, gestational HTN, preterm delivery. https://t.co/uJirv32UYc

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“A goal without a plan is just a wish” ― Antoine de Saint-Exupéry

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Pulmonary arterial hypertension is a very uncommon complication of Adult onset Stills disease - 4.8% of 41 AOSD pts developed PAH - often severe, with a mortality risk. https://t.co/XjyVArMNBl

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The Downside of social media for patients: 1. if substituted for in-person support, 2. Misinformation, 3. Financial exploitation, 4. Information overload, 5. Compromised privacy https://t.co/FtPUkZespC

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Social Media Benefits for patients: 1. Promotes engagement and empowerment 2. Provides psychosocial support, 3. informational support, 4. improves MD-patient relationship, 5. linical trials and cancer research education https://t.co/FtPUkZespC

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Eli Lilly has announced that FDA has granted Fast Track designation to baricitinib, to be studied for the treatment of systemic lupus erythematosus (SLE). This drug is NOT FDA approved for lupus https://t.co/vK7i6AoKab

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Congratulations to Professor Iain McInnes - he is one of the Queen's New Year Honours in Scotland, as a Commander of the Order of the British Empire (CBE), for his services to medicine. https://t.co/15bIELJiEj

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Full text review of psoriatic arthritis for NPs and PAs https://t.co/hlLKLAQ9ZX

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Abbvie has submitted its new JAK inhibitor, upadacitinib, to the FDA and EMA for consideration in moderate to severe rheumatoid arthritis https://t.co/49GspIEeYN

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Best wishes for a charmed 2019! My advice: 1. Just show up. 2. If you can, then you must do. 3. Live each day as if it twas your 1st day/last day/make or break day. 4. Teach

Dr. John Cush RheumNow ( View Tweet)

“Never turn down an opportunity and don’t be afraid to address your failures”. - NFL great, Michael Strathan

Dr. John Cush RheumNow ( View Tweet)

"I'm addicted to placebos. I'd give them up, but it wouldn't make any difference." - Steven Wright

Dr. John Cush RheumNow ( View Tweet)

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