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RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

Sep 24, 2020 10:00 pm

Dr. Jack Cush reviews the news and Journal articles from the past week on RheumNow.com.

  1. Rheums Win Big in 2021! According to the estimates from the Centers for Medicare & Medicaid Services (CMS), endocrinologists and rheumatologists are the big winners, at 17% and 16% projected increases, respectively https://t.co/I6etQZnFlv

  2. The EMAs Committee for Medicinal Products for Human Use (CHMP) has recommended baricitinib for approval in adults with moderate-to-severe atopic dermatitis who are candidates for systemic therapy https://t.co/goEacN1C8X

  3. Cluster analysis of 168 antiphospholipid pts shows that having arterial thromboses and cardiovascular risk factors was associated with mortality and poorest prognosis in APS. https://t.co/Nb7lZNu4jT

  4. Ann Int Med shows again that steroids increase serious infection risk in a dose dependent manner, but even 5 mg of prednisone or less also gives a small but significant risk of serious infection in RA patients on DMARDs (claims data from Medicare & Optum) https://t.co/bj41SqKP0K

  5. A machine-learning algorithm was developed using MRI data from the Osteoarthritis Initiative capable of predicting osteoarthritic progressors from baseline cartilage texture maps ; Had a test accuracy of 78% in detecting OA progression 3 y prior to Sxs https://t.co/OPw9KGb4jr

  6. Outcomes survey of 229 relapsing polychondritis patients shows that 59% had auricular-onset (AO) and 21% had respiratory -onset (RO), 20% w/ miscellaneous-onset (MO- eye MSK CNS). Poorer prognosis seen in RO & MO subgroups than AO subgroups https://t.co/rzVU42z3EA

  7. 6.6% Risk of Late-onset Neutropenia (ANC<1000) in a single center study of 738 Rx w/ Rituximab (107 LON in 71 patients). Incidence was 7.2/100PYs. Higher risk w/ SLE or CTX Rx. 40% had Sxs, Fever 31%, sepsis in 8.5%. Rechallenge in 87% & 21% recurrent LON https://t.co/XXFV1lH9jS

  8. Metanalysis presented at European Association for the Study of Diabetes (EASD), involving1,629,854 participants and found #RA was associated with a 23% higher chance of developing T2D, compared to the diabetes risk within the general population https://t.co/Qff7gpzves

  9. Ustekinumab Early Risk for Cardiovascular Events

  10. High-risk coronary plaques (LRNC) assessed by Coronary CT scores in 209 biologic naive Psoriasis pts. LNRC correlated w/ Framingham risk & Dz activity. After 1 year those on biologics had signif reduction in LRNC, but those not on biologics had no change https://bit.ly/2G0PY0x

  11. CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

  12. Young Adults are Driving Up COVID-19 Rates

  13. As of 20 Sept, CDC reports total US COVID-19 deaths to be 198,754. In the last 7 days 281,490 new Cases. Trends flat averaging ~40,000 Cases per day and ~600-1100 deaths per day. https://t.co/CPLVhz6qeH

  14. Romilkimab Effective in Early Diffuse Systemic Sclerosis 

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