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RheumNow Podcast – Can RA Be Prevented (12.7.18)

d Jack Cush, MD

Dr. Jack Cush reviews the news and new journal articles from the past week on RheumNow.com:

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Chronic Kidney Disease Increasing in the U.S.A.

d Jack Cush, MD

JAMA has published the Global Burden of Disease (GBD) study showing that that, from 2002 to 2016, the US burden of chronic kidney disease (CKD) increased, with some states exhibiting more than twice the burden as others.

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Deprescribing to Battle Polypharmacy

d Jack Cush, MD

The Gerontological Society of America has published a report calling for deprescribing as a means of managing polypharmacy in the elderly.

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The Benefits of a Lupus Clinic

d Jack Cush, MD

A comparative cohort study assessing the quality of care in patients with systemic lupus erythematosus (SLE) suggests that a dedicated lupus clinic has better quality measure performance compared to lupus management in a general rheumatology clinic.

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PRAIRI Study - Can RA Be Prevented?

d RheumNow

B-cell depletion may offer a means of delaying the onset of clinical arthritis in adults at high risk, according to the PRAIRI study - a proof-of-mechanism study in pre-clinical RA patients. 

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New ACR/NPF Guidelines for Management of Psoriatic Arthritis

d Jack Cush, MD

The American College of Rheumatology (ACR) and National Psoriasis Foundation (NPF) have released a joint treatment guideline for psoriatic arthritis (PsA) that provides evidence-based pharmacologic and non-pharmacologic recommendations and includes recommendations on other management issues inclu

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Dendrimer Nanocarrier Delivers IGF-1 to Degenerative Cartilage

d Jack Cush, MD

Researchers from MIT have developed a novel treatment for osteoarthritis (OA) by using dendrimer-based nanocarriers to deliver insulin-like growth factor 1 (IGF-1) to chondrocytes within joint cartilage and in animal models have shown when these nanocarriers injected into rat knees in models of O

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RheumNow Podcast is Up - Can RA be Prevented? watch here https://t.co/enxuQcF0qf or listen on iTunes, Stitcher or Soundcloud https://t.co/nmK3h2ri7I https://t.co/qS33jbtaUt

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Dr. John Cush RheumNow ( View Tweet)
The Best Rheums go to the Best Meetings - RHEUMNOW LIVE - March 22-24 2019 Great Venue =Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

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Dr. John Cush RheumNow ( View Tweet)

As we continue our efforts to reduce the high cost of prescription drugs, meetings with groups like @ArthritisFdn and @ACRheum provide important insight into the needs of patients and physicians. https://t.co/jOOK4THTQ6
Secretary Alex Azar SecAzar ( View Tweet)
Bipartisan senators introduce new drug pricing bill https://t.co/mDWxPEtHhz

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Angus Worthing MD AngusWorthing ( View Tweet)

J. Hopkins study of 27 pts with inflammatory arthritis due to immune checkpoint inhibitors (mostly European ancestry) shows higher rate (61.5%) of at least 1 Shared Epitope allele (similar to RA pts) but were more likely to be seronegative for RF or CCP https://t.co/uR7ESZ2s07

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Dr. John Cush RheumNow ( View Tweet)

Direct Antiglobulin Test (DAT) or Coombs test reviewed in JAMA - hemolysis can be suggested by low haptoglobin, high LDH &reticulocytosis- a positive IgG DAT indicates warm AIHA. An IgM & anti-C3d activity --> cold agglutinin Dz https://t.co/XLZHtISTjn

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Dr. John Cush RheumNow ( View Tweet)

An interesting read in JAMA - how a patient developed his own "tool kit" to manage fibromyalgia - cannibis, exercise, diet, massage, PT, CBT. A story of serendipity, inadequate insurance coverage & woefulness of current pain management https://t.co/DIiuqSbkJ8

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Dr. John Cush RheumNow ( View Tweet)

CARRA reports it has completed enrollment of 403 newly diagnosed polyarticular JIA patients in STOP-JIA (Start Time Optimization of Biologic Therapy in Polyarticular JIA). Results anticipated in late 2019. https://t.co/V2qvZCRXvs

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Dr. John Cush RheumNow ( View Tweet)

Retrospective study of 65 093 obese adults w/ bariatric surgery shows that, although Rouxen-Y gastric bypass had more wt. loss than gastric sleeve > gastric banding; RYGB had more 30-day major adverse events - Gastric Sleeve wins? https://t.co/R0Fday00Bh

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Dr. John Cush RheumNow ( View Tweet)

Interdisciplinary guidelines for treating Uveitis in JIA - 1) Topical steroids; 2) if not improved, MTX; 3) Then TNF inhibitor; 4) systemic steroids; or 5) other biologics (TCZ, ABA, RTX). https://t.co/6D1aq3xQqA

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Dr. John Cush RheumNow ( View Tweet)

Cohort study 56866 RA/PsA/AS patients compared 287 w/ multiple myeloma & 2760 matched controls - no difference in MM risk related to biologic, DMARD or NSAIDs. But compared to DMARD only pts, Biologic + DMARD users had a 48% lower risk of MM (OR 0.52) https://t.co/DsmvNXC9c9

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Dr. John Cush RheumNow ( View Tweet)

Open source review Assessing Disease Activity in Psoriatic Arthritis: A Literature Review by Drs Tucker, Coates, Helliwell. How to assess arthritis, dactylitis, enthesitis, axial disease, skin & patient measures (PROMs). https://t.co/5SLwpeGbkn

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Dr. John Cush RheumNow ( View Tweet)

Depression worsens back pain; increases healthcare costs. Medicare claims study 73,000 found 6,739 with back pain & 20% of these (1310) had depression. Annual healthcare costs substantially higher in LBP pts w/ depression ($13,153 vs $7,477, P < 0.001). https://t.co/rHqfWPTV7r

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Dr. John Cush RheumNow ( View Tweet)

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