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Dendrimer Nanocarrier Delivers IGF-1 to Degenerative Cartilage

d Jack Cush, MD

Researchers from MIT have developed a novel treatment for osteoarthritis (OA) by using dendrimer-based nanocarriers to deliver insulin-like growth factor 1 (IGF-1) to chondrocytes within joint cartilage and in animal models have shown when these nanocarriers injected into rat knees in models of O

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Limited Impact of Vitamin D Supplementation

d Jack Cush, MD

A systematic review of 81 studies on vitamin D concludes that vitamin D supplementation does not prevent fractures or falls, or have clinically meaningful effects on bone mineral density.

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Filgotinib in Psoriatic Arthritis and Ankylosing Spondylitis

d Jack Cush, MD

Another, new Janus kinase 1 (JAK1) inhibitor is out with impressive data - this time its filgotinib, demonstrating its efficacy and safety two separate clinical trials of patients with psoriatic arthritis or ankylosing spondylitis.

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RheumNow Podcast – To Needle or Not to Needle (11.30.18)

d Jack Cush, MD

Dr. Jack Cush updates the news and reports from the past week at RheumNow.com:

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Depression worsens back pain; increases healthcare costs. Medicare claims study 73,000 found 6,739 with back pain & 20% of these (1310) had depression. Annual healthcare costs substantially higher in LBP pts w/ depression ($13,153 vs $7,477, P < 0.001). https://t.co/rHqfWPTV7r

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Dr. John Cush RheumNow ( View Tweet)

CDC reports that 40-47% of adults have had a flu vaccination in the past 12 months (higher in elderly (67%). https://t.co/RPmkTECeF7

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Dr. John Cush RheumNow ( View Tweet)

Bisphosphonate safety review — risk of Atypical Femoral Fracture is 1/1000 and risk of osteonecrosis of the jaw is 1/10,000. One-third of IV zolendronic acid pts will have arthralgia/myalgias or flu like sxs. https://t.co/80xBkZlKgn

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Dr. John Cush RheumNow ( View Tweet)

FDA has approved Genentechs ACTpen - a tocilizumab autoinjector 162 mg sc for use in RA, GCA, poly and systemic JIA - should be available in January 2019. https://t.co/YzFHyYxQlS

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Dr. John Cush RheumNow ( View Tweet)

Study of 2053 RA patients from VA medical centers found 27% with chronic lung disease that confered a 51% increased mortality risk; sadly this was not altered by MTX or biologic therapy. https://t.co/nYFnScSXQ4

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Dr. John Cush RheumNow ( View Tweet)

I prefer more slides with less data per slide rather than fewer slides jam packed with multiple miniscule figures #ASH18

John P. Leonard, MD JohnPLeonardMD ( View Tweet)

We are not only doctors for the elderly. Many of our patients are young or even children. Sometimes we treat banal conditions but also we manage severe & autoimmune disorders with systemic involvement. We use innovative therapies. Didn't you know us? We are the Rheumatologists

Emilio Martin Mola emartinmola ( View Tweet)

This is a great conference! https://t.co/GEDlj44jLE

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Dr. John Cush RheumNow ( View Tweet)

2017 US life expectancy decreased for the 3rd year in a row. Drug overdoses & suicides lead the trend, resulting in earlier deaths and how long people live. Life expectancy dropped 78.7 yrs in 2016 to 78.6 yrs in 2017, with changes in men; not women https://t.co/gUParIkR6W

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Dr. John Cush RheumNow ( View Tweet)

Dont Miss the Next Best Meeting in Rheumatology - RHEUMNOW LIVE - March 22-24 2019 in beautiful downtown Fort Worth. Short Lectures, interactive sessions, Q&A panels, TED (like) Talks, digital, streaming and much more. You dont want to miss this meeting! https://t.co/5TVg0Frsbf

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Dr. John Cush RheumNow ( View Tweet)

The RheumNow Podcast is Up! To Needle or Not to Needle; Watch https://t.co/pjYZh5LXzi or listent to the weekly news and review https://t.co/AmXgjki2dL

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Dr. John Cush RheumNow ( View Tweet)

296 women with HTN during pregnancy (half/147 NSAID-exposed) - NSAID use was not associated with a significant change in BP (vs no NSAID) and there was no added need to start or increase BP meds in those on NSAIDS. https://t.co/csDljBJI3r

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Dr. John Cush RheumNow ( View Tweet)

AstraZeneca today announced the FDA has granted Orphan Drug Status for Fasenra (benralizumab) for Eosinophilic Granulomatosis with Polyangiitis (EGPA). Fasenra is also approved for severe, eosinophilic asthma https://t.co/4ChX8D5Evx

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Dr. John Cush RheumNow ( View Tweet)

Cohort VAMC study shows that Diabetes management (A1C, LDL, HTN) (n=368,481 patients) and outcomes were the same between physicians (n 3487), nurse practitioners (1445) and physician assistants (443). https://t.co/ToNVcPrMZN

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Dr. John Cush RheumNow ( View Tweet)

Amyotrophic lateral sclerosis, AKA Lou Gehrig’s dz (ALS), a progressive/fatal neuromuscular dz has an estimated prevalence of 5.2 per 100,000 - with a total of 16,583 cases identified. The majority of ALS patients die within 2–5 years of a diagnosis. https://t.co/Yg7aIspfnN

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Dr. John Cush RheumNow ( View Tweet)

What’s Next in Biosimilars is one of several educational videos available in the "Therapeutic Update: Biosimilars in Rheumatology" video series, sponsored by Sandoz, Inc. and now available on RheumNow. https://t.co/1vmnEJqOSi

Links:

Dr. John Cush RheumNow ( View Tweet)

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