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Hit Parade Review (8.12.2022)

Jack Cush, MD

We've got a lot to discuss this week: psoriasis; fatigue; sleep; sural nerve biopsies; uveitis and SpA; diet and RA; tofacitinib and the ORAL surveillance study; what not to take with mycophenolate - and more. In what order should these items be discussed? This week the run down is based on popularity, measured by rheumatologist engagements on the website and social media.

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The Great Unknowns (8.5.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news, FDA approvals, journal articles from the past week on RheumNow; plus viewer questions. This week great hopes for vitamin D, the great unknows of CSA and the great big mess that is the gout.

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ACR guidance

ACR Updated Guideline on Vaccinations for Rheumatic Patients

Jack Cush, MD

The ACR has posted a new ACR Clinical Practice Guideline Summary providing recommendations on the use of vaccinations for children and adults with rheumatic and musculoskeletal diseases (RMDs).

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ICYMI: 2021 Rheumatology Year in Review

Jack Cush, MD

For 2022, let's look our top 10 list of advances, game-changers, worries and those better medical practices that evolved during 2021.

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What Worries You, Masters You (7.1.2022)

Jack Cush, MD

Dr. Jack Cush reviews recent news, regulatory and guideline updates from the past week on RheumNow.com.  Studies on methotrexate use, COVID vaccination, Supplements and vitamins, and arthrocentesis despite anticoagulation are discussed.

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Two Week Methotrexate Hold with COVID-19 Vaccination

Jack Cush, MD

A cohort study of rheumatoid arthritis (RA) patients evaluated immunogenicity of COVID vaccination with and without holding methotrexate (MTX) for and 2-weeks and showed better immunogenicity, but more RA flares with the second MTX withdrawal. 

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COVID Test Antibody

COVID-19 Death is Dependent on Age and Type I IFN Autoantibodies

Jack Cush, MD

A study in PNAS of has shown that autoantibodies against type I interferons (IFNs) are strong predictors of death from COVID-19.

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CDC has updated COVID-19 guidelines - People COVID exposed: no need to quarantine, regardless of Vax status, but use mask x10 d & get tested day 5 - Surveillance testing without Sxs not recommended - if COVID test +, should isolate at home x 5d https://t.co/whVQShsSJR? https://t.co/KnYtJ7BfOO

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Dr. John Cush RheumNow ( View Tweet)
Evusheld works & reduces COVID-19 by 77%; yet only 25% of available Rx has been used. Its FREE to the ~7000 immunocompromised pts who might benefit from it. Repeat doses (300 mg) every 6 mos! Time to jump on this! https://t.co/IzcAUvKoW8 https://t.co/h5q25yWCHG

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Dr. John Cush RheumNow ( View Tweet)
In the RECOVERY trial - 8156 hospitalized COVID-19 patients; those on baricitinib had significantly fewer deaths (12% vs 14% PBO) but the size of benefit was somewhat smaller than that suggested by previous trials. (adjusted rate ratio 0·87) https://t.co/EW7xLc9TLC https://t.co/Ahr7bwAQmJ

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Dr. John Cush RheumNow ( View Tweet)
I had the chance to discuss intrinsic protection from Covid with my friend @ASlavitt https://t.co/dI993XBoXr https://t.co/lidQnzgjJg

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Eric Topol EricTopol ( View Tweet)

Every moderately to severely immunocompromised person should know about Evusheld, a preventive Rx. It's uncommonly prescribed by doctors and there's a general lack of awareness. Still works vs BA.5 An excellent patient page @JAMA_current https://t.co/Exn82D8712 @AnuMalaniMD https://t.co/Rpdhcgg33h

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Eric Topol EricTopol ( View Tweet)
Anyone who thinks BA.5 is just another variant isn't paying attention >200,000 new cases yesterday. Vertical. https://t.co/x7wziHMZ9K
Eric Topol EricTopol ( View Tweet)
During 2021-22, there was 387,112 deaths due to pneumonia, influenza, or COVID-19. At least 72% were dut to COVID-19 and 0.6% was due to influenza https://t.co/0ljpXJt0yr https://t.co/1Sp4RULVAY

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Dr. John Cush RheumNow ( View Tweet)
🆕🌟CDC Guidance on COVID-19 Vaccines for Children <18 yrs who are Immunocompromised 👦👧🏾💉⬇️ Thank you Dr. Rebecca Sadun for reviewing! #PedsTwitter #PedsRheum #Pediatrics https://t.co/eeuRKflhSO
Mithu Maheswaranathan, MD MithuRheum ( View Tweet)
CDC: Immunocompromised account for 12.2% of all COVID-19 hospitalizations, with an increased risk of ICU (aOR=1.26) and death (aOR = 1.34), even if vaccinated (aOR 1.40; aOR = 1.87). In immunocompromised, death rate was not affected by vaccination. https://t.co/PVRnOPb9gX https://t.co/W2S9eb1cOo

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Dr. John Cush RheumNow ( View Tweet)
New podcast up—“What Worries You, Masters You” We review recent news, regulatory and guideline updates from the past week. Studies on MTX use, COVID vaccination, Supplements and vitamins, and arthrocentesis despite anticoagulation are discussed. https://t.co/jRaLCQAt9K https://t.co/opa22JqU41

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Dr. John Cush RheumNow ( View Tweet)
Patients in the COVID-19 Global Rheumatology Alliance were Surveyed; responses from 9300 Rheum Dz adults (RA 39%, SLE 31%) showed that 27% had a change in employment status during COVID (w/ 13.6% decrease in full-time employment) https://t.co/exi6KDmMGT https://t.co/fPl091rXdO

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Dr. John Cush RheumNow ( View Tweet)
Two Week MTX Hold with COVID-19 Vaccination A cohort study of RA patients evaluated immunogenicity of COVID vaccination with and without holding MTX for and 2-weeks and showed better immunogenicity, but more RA flares with the second MTX withdrawal. https://t.co/Kqa8Uy9tDm https://t.co/UvMHo8xAw8

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Dr. John Cush RheumNow ( View Tweet)
COVID-19 Death is Dependent on Age and Type I IFN Autoantibodies https://t.co/WrWujgHoA4 https://t.co/NTwUeXHYKr

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Dr. John Cush RheumNow ( View Tweet)
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