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Checkpoint Inhibitor-related Myositis – Something Different
As expected, this year’s ACR meeting saw an upswing in the number of abstracts on immune related adverse events from checkpoint inhibitor therapy compared to last year.
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Pooled analysis from 3 PSA+12 PSO trials on ixekizumab RCTs. Reassuring that incidence of IBD relatively low with significant pt year f/u (https://t.co/icWfGIEnxt @RheumNow #ACR18
Arthur Lau ArthurRheum ( View Tweet)
Now available: https://t.co/QrHTupEmaN. #acr18 https://t.co/N7dWlp3zz2
Dr. John Cush RheumNow ( View Tweet)
SEAM PSA study: wow MTX monotherapy was surprisingly good for ACR scores (ETN clearly better especially for high bar outcomes, but not too shabby at all for MTX mono)
https://t.co/dc2vYFs8pY @RheumNow #ACR18
Arthur Lau ArthurRheum ( View Tweet)
ETN plus MTX combo better for skin PSO outcomes, but not a huge improvement for joints... but remember this study used ETN 50 q week (not twice weekly like used for PSO) @RheumNow
Arthur Lau ArthurRheum ( View Tweet)
LB abstract L06: Genovese et al. Filgotinib (JAK1-i) for treatment of RA after biologic failure. ACR 20/50/70 = 70/46/32% by 24 weeks. No GI perforations seen. #ACR18 @RheumNow https://t.co/5rAqz7ljXO
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Spiegal: Challenges in usability. in 2015 Cedars-Sinai allowed smartphone data to input into the EHR via Apple’s HealthKit framework. Out of nearly 80,000 invited patents, 499 connected (0.8%) = younger patients, few comorbidites, hospital employees. #ACR18 @Rheumnow https://t.co/HUPtbvGpVL
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Spiegal: Hyperpersonalize example of an app helping to increase activity level: “Today is a nice day outside, it will be good if you go out and go for a walk.”
#ACR18
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Spiegal: For reference: IDEAS (Integrate, Design, Assess, and Share) Framework and toolkit for development of effective digital interventions for health behavior. Mummah et al. J. Med Internet Research 2016. #ACR18 @RheumNow
Suleman Bhana, MD DrBhana ( View Tweet)
This is an *extremely* important study in ANCA-vasculitis. Looking forward to really digging into this data. #ACR18 https://t.co/OX0YPwQrCD
Paul Sufka, MD psufka ( View Tweet)
PET CT protocol with high NPV (98%)could be used as a first-line test to rule out GCA vs bx. https://t.co/yQEyQyHcDx @RheumNow #ACR18 L15
Links:
Dr. Rachel Tate uptoTate ( View Tweet)
2828 Utility of Fecal Calprotectin Levels for the Diagnosis of Inflammatory Bowel Disease in Patients with Spondylorarthritis #ACR18 https://t.co/QUPgiwT1dt
Jose Campos JoseCamposMD ( View Tweet)
Dr. Polly Ferguson
SAPHO dx criteria, Kahn 2003
including
-bone /joint involvement with psoriasis
-bone joint with severe acne
-isolated steroid hyperostosis/osteeitis
-CRMO (children)
-bone-joint with IBD
excluding:
-bone tumor
-non inflammatory
#ACR18 @RheumNow
Suleman Bhana, MD DrBhana ( View Tweet)
Common patient concern: Humira and pregnancy.
IgG does not cross the placenta until 12-15 weeks. Consider discontinuing in late second trimester or early third trimester to avoid high serum drug concentrations in the newborn 🤰🏻 #ACR18 #CleClinicRheum
Emily Littlejohn ELittlejohnDO ( View Tweet)
Dr. Kavanaugh: Abstract 826.
https://t.co/X0MKvAO3UV
Does Anti-Glomerular Basement (anti-GBM) Antibody Positivity Correlate with Relapse in Patients with Anti-GBM Disease? —Presence of ANCA predicts relapse. #ACR18 @RheumNow
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Cush
ABSTRACT 898
Efficacy and Safety of Tocilizumab for the Treatment of Systemic Sclerosis: Results from a Phase 3 Randomized Controlled Trial —missed RSSS outcome, but improved lung function #ACR18 @Rheumnow
https://t.co/E7LdBEfXWc
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Kavanaugh: Abstract 1068.
Role of Cannabinoid CB2 Receptor Agonist, in IL-1β-Induced Inflammation in RA Synovial Fibroblasts —CB2 therapeutic target
#ACR18 @RheumNow
https://t.co/fZoPnLKQcjβ-induced-inflammation-in-human-rheumatoid-arthr…
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Cush
abstract 428
Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Controlled Phase III Trial of Treatment Effectiveness —improved pain but not clinically meaningful
#ACR18 @Rheumnow
https://t.co/S9wHaKjDLB
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Kavanaugh
Highlighting a Session: ACR Immunology update
B Cell directed therapy, Dr. R. John Looney from Rochester, NY
“Next Generation of B Cell and Plasma Cell Therapies” —looking for new targeted therapies
#ACR18 @RheumNow
Suleman Bhana, MD DrBhana ( View Tweet)
Dr. Kavanaugh
ABSTRACT: 1234
Incidence of Conversion of Screening Tests for TB (PPD, GIF-release assay) in Patients Treated with TNF-α Inhibitors —small no. of patients converted but in higher risk patients
https://t.co/k6nRyIGGlUα-inhibitors/
#ACR18 @RheumNow
Suleman Bhana, MD DrBhana ( View Tweet)