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RheumNow Podcast- Methotrexate Mechanisms (2.28.20)

d Jack Cush, MD

Dr Jack Cush Reviews the news and journal articles from the past week on RheumNow.com

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Fatigue Looms Large in Lupus

d RheumNow

Fatigue is an important component of the disease experience in systemic lupus erythematosus (SLE), and can have a profound impact on patients' perception of well-being, Italian researchers reported.

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Why You Should Come to RheumNow Live March 13th

d Jack Cush, MD

RheumNow Live kicks off its second annual meeting - a little, big meeting in Fort Worth - in just 2 weeks and I think you should be there.

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Bariatric Surgery Improves Rheumatoid Activity

d Jack Cush, MD

Obesity is a risk factor for the onset of rheumatoid arthritis (RA) and may also an impediment to optimal DMARD and biologic responses.  A new study has shown that after 1 year, obese RA patients undergoing bariatric surgery with weight loss had significantly lower disease activity.

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ACR Releases Reproductive Health Guidelines for Rheumatic Diseases

d Jack Cush, MD

Today, the American College of Rheumatology (ACR) published the 2020 Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases.

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Methotrexate and the Risk of Lung Disease

d Kathryn Dao, MD

Rheumatology has a comprehensive overview of methotrexate (MTX) and the risk of lung injury, MTX-related pneumonitis and interstitial lung disease (RA-ILD) with rheumatoid arthritis (RA).  Past reports suggest the frequence of MTX-pneumonitis to be between 0.3 and 11.6%; r

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U.S. FDA Accepts Regulatory Submission for Tanezumab, an NGF inhibitor, for the Treatment for Patients with Chronic Pain Due to Moderate-to-Severe Osteoarthritis https://t.co/9NsESTnn4S

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Dr. John Cush RheumNow ( View Tweet)

"He has all of the virtues I dislike and none of the vices I admire." -Winston Churchill

Dr. John Cush RheumNow ( View Tweet)

QD Clinic - Cases, insights and RNL info. Listen to the podcasts on iTunes or here https://t.co/V60JN2ZdYF

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Dr. John Cush RheumNow ( View Tweet)

The RHeumNow Podcast is up. https://t.co/pD2fWDsCOJ Checkout the podcast >> https://t.co/x0RytGbNYi

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Dr. John Cush RheumNow ( View Tweet)

Long term safety of Sarilumab reviewed. 2887 SAR pts on Combo and 471 on SAR mono Rx for up to 7.3 yrs (8188 PYs). SAEs 9.4 & 6.7/100PY; SIE 3.7 &, H zoster (0.5-0.6/100PY), GI perforations < 0.1/100PY & Cancer 0.7-.6. ANC <1000 in 13-15% https://t.co/YA2TKCdpGY

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Dr. John Cush RheumNow ( View Tweet)

Study of metformin in NON-diabetics w/ inflammatory disease on Pred >20/d shows metformin to to reduce pneumonia, serious infections, markers of carbohydrate/lipid,/liver & bone metabolism (vs PBO) but had no effect on truncal fat https://t.co/8RE2fJMkv9

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Dr. John Cush RheumNow ( View Tweet)

Prof Dinesh Khanna has an algorithm for SSc ILD. High CRP is a risk. HRCT is only low radiation so use for dx and prognosis #CRA2020 great lecture @RheumNow @earlyarthritis @sclerodermaUM https://t.co/VgltxqFKCo
Janet Pope Janetbirdope ( View Tweet)
Syphilis = The great imitator! Dx further muddled by periods of active and inactive disease. 2 main diagnostic algorithms that rely on serology, and both have pitfalls! @LCalabreseDO @NEJM @HealioRheum https://t.co/PvIG8hX0Ht https://t.co/EFTBYhK8QF

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Cassandra Calabrese CCalabreseDO ( View Tweet)
Anyone else getting hysterical patients? They want to stop their biologic because they “know” they are going to get #COVID2019 . I tell them their risk of their disease flaring off med is 100% while their risk for the infection is <1%. What do you tell your patients? @RheumNow https://t.co/2I8kVlKLOC

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k dao KDAO2011 ( View Tweet)

Hospital for Special Surgery (HSS) announced the appointment of S. Louis Bridges, Jr., MD, PhD, as the new Physician-in-Chief and Chair of the Division of Rheumatology, effective September 1, 2020. Dr. Bridges succeeds Mary K. Crow, MD https://t.co/TQ55jMOXHj

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Dr. John Cush RheumNow ( View Tweet)

HIP ATTACK trial assessed if accelerated surgery could reduce mortality & complications. 2970 Pts recv accelerated surgery (6 hr) vs standard care (24hrs). Risk of death (9-10%) & infection was the same; thus accelerated surgery did not lower risk https://t.co/Z4ld0RoRSX

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Dr. John Cush RheumNow ( View Tweet)

The use of cannabis in the past year by adults 65 years and older in the United States increased sharply from 0.4% in 2006 and 2007 to 2.9% in 2015 and 2016 https://t.co/RCVsKvGBI5

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Dr. John Cush RheumNow ( View Tweet)

"Difficulties mastered are opportunities won." - WInston Churchill

Dr. John Cush RheumNow ( View Tweet)

Brazil Biologics registry studied 1121 RA & 577 SpA pts and found serious infectious adverse events were more common with first TNFi (adjusted IR ratio, 2.96; p < 0.001) & still higher with 2nd TNFi (vs 1st TNFI) (adjusted IR ratio, 1.55) https://t.co/FpliYorsyG

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Dr. John Cush RheumNow ( View Tweet)

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