RheumNow Podcast- Methotrexate Mechanisms (2.28.20) Save
Dr Jack Cush Reviews the news and journal articles from the past week on RheumNow.com
- Long term safety of Sarilumab reviewed. 2887 SAR pts on Combo and 471 on SAR mono Rx for up to 7.3 yrs (8188 PYs). SAEs 9.4 & 6.7/100PY; SIE 3.7 &, H zoster (0.5-0.6/100PY), GI perforations < 0.1/100PY & Cancer 0.7-.6. ANC <1000 in 13-15% http://bit.ly/3adEWhV
- Study of metformin in NON-diabetics w/ inflammatory disease on Pred >20/d shows metformin to to reduce pneumonia, serious infections, markers of carbohydrate/lipid,/liver & bone metabolism (vs PBO) but had no effect on truncal fat https://t.co/8RE2fJMkv9
- HIP ATTACK trial assessed if accelerated surgery could reduce mortality & complications. 2970 Pts recv accelerated surgery (6 hr) vs standard care (24hrs). Risk of death (9-10%) & infection was the same; thus accelerated surgery did not lower risk https://t.co/Z4ld0RoRSX
- The use of cannabis in the past year by adults 65 years and older in the United States increased sharply from 0.4% in 2006 and 2007 to 2.9% in 2015 and 2016 https://t.co/RCVsKvGBI5
- Brazil Biologics registry studied 1121 RA & 577 SpA pts and found serious infectious adverse events were more common with first TNFi (adjusted IR ratio, 2.96; p < 0.001) & still higher with 2nd TNFi (vs 1st TNFI) (adjusted IR ratio, 1.55) https://t.co/FpliYorsyG
- Metanalysis of homocysteine (HCY) levels in SLE; 36 articles compared 2919 SLE to 3120 controls. HCY levels were significantly higher in SLE vs healthy controls (P < 0.001), esp w/ age, Dz activity, Dz duration and BMI >23. HCY is important in SLE https://t.co/NVQ4KRJMR4
- FDA has approved IV meloxicam injection (called Anjeso, from Baudax Bio) for the treatment of moderate to severe pain in adults. Based on two phase 3 efficacy trials and one phase 3 safety study. https://t.co/5coeDacq7M
- Cross sectional study of 139 RA patients shows that severity of periodontal disease on dental exams was linearly associated with both the presence and levels of anti-CCP antibodies. https://t.co/T4Ic5ViZgl
- Dr. Bruce Cronstein has a full read review of the MOA of MTX - is it increased adenosine release, NO2 synthase uncoupling, NF-κB effects, or the increased in long intergenic non-coding RNA p21 (lincRNA-p21)? - See his lecture at RheumNow LIVE https://t.co/uHPbiri7qo
- Bariatric Surgery Improves Rheumatoid Activity
- Hyperuricemia Predisposes to Coronary Artery Disease in Men
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