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ACR21 Best Abstracts - Day 2
The RheumNow faculty reporters have been scouring and reporting on the best abstracts from the ACR. Here is a sampling of their choice abstract presentations reported during ACR 2020 Day 2 (#ACRbest).
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Day 1 Report from ACR21
The first full day of Abstracts and Presentations from ACR Convergence, was full of highly engaging sessions, quality posters and unique presentations. To hear more about the best of the best, I would encourage you to look at our Day 1 Recap Video and Day 1 ACR Best Abstracts. Here are a few of my favorites from the first day.
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#ACR21 Abs:#1429: ALPN-303: Dual BAFF/APRIL antagonist for SLE:
⭐️Encouraging immunomodulatory activity and efficacy in animal models. ⬇️ Plasma cells and Ig secretions in vitro & vivo
⭐️Well-tolerated in animals w/o adverse events
🔥Phase 1 study in healthy volunteers!
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
#ACR21 #Abstr1420 A study checking #COVID vaccine response in 90 #lupus pts and 20 HC:
⬇️Titres of Abs in SLE vs controls
💠Factors of poor response: On any DMARDs exc HCQ only (OR 15) and normal dsDNA
📢Important to pause DMARDs in stable SLE @RheumNow https://t.co/USovFkiCRb https://t.co/bn5CC0xRS9
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
📢#ACR21 #Abstr1421 Is #COVID19 vaccine safe and effective in #lupus? YES!! VOCOLUP study (N=1189 pts) showed:
💠~45% had a side-effect; of which 80% mild/moderate
💠Only 3% flared post💉(MSK + Fatigue); 10 required hospitalisation @RheumNow #ACRBest https://t.co/WF4aAfiX70 https://t.co/jc0HQoJymo
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Young patients with #SLE #lupus have a #multimorbidity burden similar to individuals 30years older than them.
A high #comorbidity burden is present in SLE pts of all ages compared to non-SLE.
How can we address this?
Abs#1049 #ACR21 #ACRBest @RheumNow
https://t.co/U6t8YBFUZz https://t.co/v7Fwof1gZc
Mrinalini Dey DrMiniDey ( View Tweet)
Watch: Lupus Updates: Dr. Michelle Petri
Dr. Michelle Petri offers perspective and insight into lupus related data presented Saturday at the #ACR21 annual meeting.
https://t.co/L7T2mNJVH0 https://t.co/MCQ7nJjCIY
Links:
Dr. John Cush RheumNow ( View Tweet)
Stopping/reducing hydroxychloroquine (HCQ) in SLE associated with increased flares, especially for those in low disease activity or in remission. Super helpful data to share with pts wanting to reduce/dc HCQ.
#ACR21 Abst#0959 Plenary Session II @RheumNow https://t.co/i7jPDN2sgZ
Pedro Castillo _Castillo_Pedro ( View Tweet)
Dr FCardwell et al on Health Info use in SLE pts b4 and during COVID19 using an online survey
🦋#lupus specialists & fam physicians - ⬆preferred & trusted health info sources but access to them ⬇frequent during covid19
A call to action?📢
@RheumNow #ACR21 abs0880 @rheumarhyme https://t.co/1NBEAlFvHx
sheila RHEUMarampa ( View Tweet)
Dr. Petri on COVID19 infection vs vaccination on SLE activity:
💠Infection = NO increase SLE activity
💠Infection =⬇️ cutaneous activity
💠Infection = ⬆️anti-cardiolipin IgG/M
💠Vaccination: no increase in activity NOR aCL IgG/M
https://t.co/fWbotSLS3o
#ACR21 Abst#0858 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
#ACR21 #Abstr0988 Can we predict who would develop #lupus? Data from the Nurses Health Study showed the best model by combining Genetic Risk Score + Clinical & lifestyle factors (AUC:0.72). Need more diversity as most pts were White and aged 50s @RheumNow https://t.co/4KHiZbRgUK https://t.co/QV4npith9H
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
How concerned should we be for #hydroxychloroquine retinopathy. >4000 pts prospectively followed. 1/2 w RA & 15% w #SLE. New risks Asian with pericentral pattern and overall. Length of time on use and ⬆️wt based dose per day & CKD all risks. Abst#0989 #ACR21 #ACRBest @RheumNow https://t.co/XTfdQpVC7H
Janet Pope Janetbirdope ( View Tweet)
#ACR21 #Abstr0865 It’s time for T2T to achieve LLDAS in #lupus. In a study of N=2040 pts, mortality was 2.3% mainly due to infection. Remission off steroid was the best but only met in 14%. LLDAS-50 achieved in 48% pts and ⬇️mortality by 56% @RheumNow https://t.co/CddqMuFIOM https://t.co/g346Cbybep
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR21 #Abstr0864 How does obesity (BMI=/>30) affect #lupus outcomes? Data from Toronto showed:
💠⬆️hs-CRP
💠No in disease activity over 3yrs
💠⬆️CV events (combination of low grade inflammation + hypertension)
@RheumNow https://t.co/IBu8uNSAJi https://t.co/2aqz5e3rwi
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Can patient with low dx activity SLE stop HCQ, or at least try and reduce the dose?
Not if you want to avoid flares.
If there are safer subgroups to try it in, we haven't found them yet
(in fact higher dx activity➡️less risk ?other Rx)
SLICC inception #ACR21 ABST0959 @RheumNow https://t.co/NS2V4dEGHv
David Liew drdavidliew ( View Tweet)
Keep the Hydroxychloroquine!
SLICC cohort eval flare risk in 1460 pts who⬇️or d/c HCQ:
👉pts in remission who d/c HCQ flared HR 2.77 (1.46,5.26)
👉pts in remission who⬇️dose flared HR 2.14 (1.34, 3.42)
Abst#0959 #Plenary #ACR21 @rheumnow #ACRbest https://t.co/92U215s8IP
TheDaoIndex KDAO2011 ( View Tweet)
Do you order EKGs in everyone starting HCQ? Do you avoid HCQ in patients with heart failure? Will these abstracts impact your practice? Click on link to read more....#ACR21 @rheumnow #HCQ https://t.co/fvUZAvNWa8
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21 #Abstr0858 Petri reported effect of #COVID and vaccination in #lupus cohort
💠No increase in activity post-infection
💠⬇️cutaneous activity
💠⬆️ aCL IgG and IgM post-infection,
💠No increase in SLE activity or aCL abs post-vaccination
@RheumNow https://t.co/iAaIfzf33c https://t.co/hA6sk6icrs
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Pearl: Most oral lesions in #lupus are painless. The classic oral lesion is a lacy, reticular pattern superimposed on an erythematous plaque.
@RheumNow #ACR21 https://t.co/nxWnppxsZI
sheila RHEUMarampa ( View Tweet)
HZV in pts w/ #rheumatic dse by Dr CCMok et al
🔸Prevalence rates of HZV infxn (per 100py): SLE 1.7, RA 0.64, other RDs 0.76
🔸RFs assoc'd w/1st HZV infection
📌#SLE dx, serum albumin, serum creatinine; ⬆lympho/neutro ratio, CYC & Prednisolone use
@RheumNow #ACR21 abs0862 https://t.co/TXRmoBBDXK
sheila RHEUMarampa ( View Tweet)
