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#IgG4 RD is an indolent disease but can present with severe weight loss (>20 pounds), largely due to pancreatic destruction. #ACR18 @RheumNow

Brittany A MissbeeMD ( View Tweet)

Therapeutic potential of “glycoengineering" in autoimmune disease. Alter glycoforms of endogenous IgG -> reduce pathogenic impact of antibodies. Cell paper by Pagan JD et al https://t.co/UbBsE1jV4L Year in review basic science #ACR18 @RheumNow

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D White WIRheum ( View Tweet)

TLR8 aberrantly expressed on pDCs (cells that make type-I IFN) in SSc patients Depletion ameliorates disease https://t.co/SmDdpIU2I1 Ah Kioon et al Year in review basic science #ACR18 @RheumNow

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D White WIRheum ( View Tweet)

Stop by the ⁦@RheumResearch⁩ booth to get your ⁦@alhkim⁩ autographed flyers!!! #acr18 #rheumrockstars https://t.co/kVR4XB6ynO
Mary J. Wheatley MaryJWheatley ( View Tweet)
Anti-GBM positivity did not predict relapse in Goodpasture's (but ANCA did predict relapse in GBM disease) Abs 826, Cleveland Clinic Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

Toci in SSc failed to achieve primary endpoint (modified Rodman skin score) Abs 898 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

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Canabinoids in vitro CB2 receptor drives inflammation Set the stage for discovery/development of future antagonists? Danger of over-interpretation on the street Abs 1068 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

MTX for OA of the knee 12 months, 155 pts, endpoint=pain statistically significant improvement, probably not clinically meaningful consistent with prior reports Abs 428 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

B cell immunology New therapies directed at B cells Overlap with therapies for myeloma How to target long-lived (CD20 neg) plasma cells? Session: ACR immunology update Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

Session on draft ACR reproductive health guidelines Three manuscripts in preparation This effort is a response to a tremendous need for info and guidance Estimated half of pregnancies are unplanned, so ask patients often Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

MTB screening in patients on TNFi When to re-screen? Neg to pos conversion discovered in a small number of cases Often in patients with risk factors Cush: Annual testing “makes no sense at all" Abs 1234, Rochester NY Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

DIP involvement in RA 12k patients in Japanese registry 2% incidence, 2-3 joints in each pt with involvement associated with higher disease activity Abs 221 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

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Biosimilars in Sweden Rx patterns (originator vs biosimilar) follow prices - back and forth Abs 1175 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

Gout Remains under-treated Higher success when pharmacists and RNs manage ULT Abs 2220, 1247, 1272 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

Enthesitis, in particular supraspinatus tendinopathy IL-17A as a target of therapy Abs 404 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

MTX helpful for granulomatous mastitis Can be recurrent; sometimes seen by rheums Rule out cancer, infection Abs 2264 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

Chronic back pain in patients with a FHx of ank spond More psoriasis and heel pain Undiagnosed SpA? Abs 637 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

High- vs standard-dose influenza vaccination in pts on DMARDs and biologics High-dose quadrivalent version more effective (seroconversion) except in rituximab population Abs 837 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

MTX vs etanercept vs combo in PsA ACR20 at 24 wks: 50%, 60%, 65% Contrast TEMPO study in RA where combo therapy was better than monotherapy Also: MTX monotherapy effective Abs L11 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

Plasma exchange in AAV (GPA or MPA) with severe disease PLEx did not reduce ESRD or death Reduced-dose glucocorticoids did not increase risk of death or ESRD (but did have fewer infections) Abs 2788 Roundup - Cush, Kavanaugh #ACR18 @RheumNow

D White WIRheum ( View Tweet)

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