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ACR 2018 Podcast - Day 3

d Jack Cush, MD

Audio Highlights and Interviews from Day 3 at the ACR 2018 meeting  LISTEN HERE


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Hydroxychloroquine Dosing: the Great Debate

d Philip Gardiner

Rheumatologists tend to be a conservative bunch of people. We’re law abiding and we (mostly) follow guidelines. Which is fine when they are in the best interests of our patients, but what do we do when we fundamentally disagree?

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ACR 2018 - Day 3 Report

d Jack Cush, MD

Highlights from Tuesday, day 3 of the ACR Annual meeting in Chicago, included:



The PEXIVAS Study –  2x2 Trial of Plasma Exchange and Reduced Steroids in ANCA-Associated Vasculitis (AAV) - Abstract #2788

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Axial Spondylitis Abstracts Roundup

d Philip Gardiner

There have been a number of interesting posters and presentations covering the field of axial spondyloarthropathy. I’ve picked out a few points that I found particularly relevant.



Classification Criteria

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such a great abstract @cappelliMD looking at effect of rheumatic irAE on patients quality of life, as expected - a significant impact! abstract #2349 @RheumNow @LCalabreseDO #ACR18

Cassandra Calabrese CCalabreseDO ( View Tweet)

#ACR18 @rheumnow abs 2646 lower use of AMs in lupus nephritis patients treated by nephrologists. But this group had much higher creatinine and many on dialysis, so seems appropriate to a large extent? Discuss..... https://t.co/bmptvvTKCh
Ian N Bruce Lupusdoc ( View Tweet)
Is serum calcoprotectin a new biomarker for developing RA? Fecal calprotectin is used for disease activity in Crohns. ABST 1863 showed better prediction adding to RF &CCP. Not sure of clinical relevance yet. ACR18 @RheumNow https://t.co/Pym49j3iz2
Janet Pope Janetbirdope ( View Tweet)
#Plaquenil related #hyperpigmentation can occur soon after starting tx even though usually associated with long term use. By dermatologist Dr. Victoria Werth #ACR18 @RheumNow

Nicole Bitencourt NicoleBitencou5 ( View Tweet)

ACR highlights. Many Scleroderma trials were close to positive. Tocilizumab, Abatacept & Riociguat. In PsA safety and effectiveness of IL17 and also apremilast persist. Jaki safety and benefit in RA and no new signals of VTE. New SLE criteria #ACR18 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

YOU need to know about checkpoint inhibitors for immune surveillance to treat melanoma and other cancers. Immune mediated adverse events presented at this mtg range from 7 ~70% depending on drug, pts, Cancer. Rx with 2 inhibitors increases risk. MSk problems 2% #ACR18 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

patients underoing lung transplant for ILD in rheumatic disease have similar long-term survival rates compared to those transplanted for IPF, abstract #2974 @RheumNow #ACR18

Cassandra Calabrese CCalabreseDO ( View Tweet)

In #SystemicSclerosis, presence of higher #antivinculin antibodies (Ab against a cytoskeletal protein, also seen in IBS) was found among pts w more severe #scleroderma related GI disease. Was also assoc with scleroderma PAH/vasculopathy. Abstract 2937Dr. Suliman #ACR18 @RheumNow

Nicole Bitencourt NicoleBitencou5 ( View Tweet)

#ACR18 #2925 - Fascinating study by Xenofon Baraliakos: vertebral fatty lesions (defined by MRI) in AS biopsied at spinal surgery. Confirms that fatty lesions indeed contain fat (in contrast to degen discs). Adipocytes seem to favour osteoblast activity. @RheumNow https://t.co/m2h6tvCwQQ
ǝlʇʇıɥʍ ɯɐs samwhittle ( View Tweet)
incidence of hypogam with rituximab is low but progressively identified overtime. infection rates remain low. abstract #2971 @RheumNow #ACR18

Cassandra Calabrese CCalabreseDO ( View Tweet)

Check out Dr. Dao's coverage of the #ACR18 meeting as well as her other blogs on https://t.co/X7Lh9aCbYf. https://t.co/G7jWZ335SR

Links:

Dr. John Cush RheumNow ( View Tweet)

#IgG4 RD: bilateral lacrimal gland enlargement can occur in IgG4-RD, GPA, Sjögren syndrome. #ACR18 @RheumNow

Brittany A MissbeeMD ( View Tweet)

Subset SSc with skin DcSSc and LcSSc and antibodies to be highly predictive for organ complications. Subsets in SSc are being updated for prognosis Abst2935 #ACR18 #GameChanger @RheumNow https://t.co/ZKFDwLBs96
Janet Pope Janetbirdope ( View Tweet)
#IgG4 RD: believed that IgG4 is not the causative agent, but rather goes into affected organs in order to downregulate an immune response. #ACR18 @RheumNow

Brittany A MissbeeMD ( View Tweet)

#pseudoobstruction of the #GItract in #SystemicSclerosis was assoc with older age, diffuse skin dz, #myopathy, U3RNP, and opiod use. Abstract2939 Dr. Eric Dein. Opiod use a potentially modifiable risk factor. #ACR18 @RheumNow

Nicole Bitencourt NicoleBitencou5 ( View Tweet)

new SLE classification criteria have been validated. need to know for clinical research and (re)certification of exams. #ACR18 @RheumNow https://t.co/1ld3yrOlE1
Janet Pope Janetbirdope ( View Tweet)
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