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Interleukin-37 Targeting in Gout

Mar 02, 2020 11:21 am

The Annals of Rheumatic Disease reports that interleukin- 27 (IL-37) may play an important role in the pathogenesis of gout, paving the way for future therapy with recombinant IL-37 in gouty arthritis.

Activation of the inflammasome by monosodium urate crystals is thought to be paramount to the innate immune response that drives IL-1-mediated joint inflammation in gout.

New research has focused on IL-37 - as it is a counterregulatory cytokine capable of suppressing IL-1 activity.

They studied 6 gout patients and found 4 rare variants in IL-37 [p.(A144P), p.(G174Dfs*16), p.(C181*) and p.(N182S)]. None of these were found in healthy controls (p=0.043). A

Treatment with recombinant IL-37 was evaluated in vitro and in vivo in a mouse model of gout and showed that recombinant IL-37 attenuated inflammation - substantiating the therapeutic potential of IL-37 in gout.

They also showed that the carrier status of p.(N182S)(rs752113534) was associated with increased risk (OR=1.81, p-value=0.031) of developing gout in hyperuricaemic individuals of Polynesian ancestry.

There may be a future role for therapeutic rIL-37 use in the treatment of gout.

The author has no conflicts of interest to disclose related to this subject

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