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#ACR21 #Abstr0865 It’s time for T2T to achieve LLDAS in #lupus. In a study of N=2040 pts, mortality was 2.3% mainly due to infection. Remission off steroid was the best but only met in 14%. LLDAS-50 achieved in 48% pts and ⬇️mortality by 56% @RheumNow https://t.co/CddqMuFIOM https://t.co/g346Cbybep
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR21 #Abstr0864 How does obesity (BMI=/>30) affect #lupus outcomes? Data from Toronto showed:
💠⬆️hs-CRP
💠No in disease activity over 3yrs
💠⬆️CV events (combination of low grade inflammation + hypertension)
@RheumNow https://t.co/IBu8uNSAJi https://t.co/2aqz5e3rwi
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Can patient with low dx activity SLE stop HCQ, or at least try and reduce the dose?
Not if you want to avoid flares.
If there are safer subgroups to try it in, we haven't found them yet
(in fact higher dx activity➡️less risk ?other Rx)
SLICC inception #ACR21 ABST0959 @RheumNow https://t.co/NS2V4dEGHv
David Liew drdavidliew ( View Tweet)
Keep the Hydroxychloroquine!
SLICC cohort eval flare risk in 1460 pts who⬇️or d/c HCQ:
👉pts in remission who d/c HCQ flared HR 2.77 (1.46,5.26)
👉pts in remission who⬇️dose flared HR 2.14 (1.34, 3.42)
Abst#0959 #Plenary #ACR21 @rheumnow #ACRbest https://t.co/92U215s8IP
TheDaoIndex KDAO2011 ( View Tweet)
Do you order EKGs in everyone starting HCQ? Do you avoid HCQ in patients with heart failure? Will these abstracts impact your practice? Click on link to read more....#ACR21 @rheumnow #HCQ https://t.co/fvUZAvNWa8
TheDaoIndex KDAO2011 ( View Tweet)
#ACR21 #Abstr0858 Petri reported effect of #COVID and vaccination in #lupus cohort
💠No increase in activity post-infection
💠⬇️cutaneous activity
💠⬆️ aCL IgG and IgM post-infection,
💠No increase in SLE activity or aCL abs post-vaccination
@RheumNow https://t.co/iAaIfzf33c https://t.co/hA6sk6icrs
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Pearl: Most oral lesions in #lupus are painless. The classic oral lesion is a lacy, reticular pattern superimposed on an erythematous plaque.
@RheumNow #ACR21 https://t.co/nxWnppxsZI
sheila RHEUMarampa ( View Tweet)
HZV in pts w/ #rheumatic dse by Dr CCMok et al
🔸Prevalence rates of HZV infxn (per 100py): SLE 1.7, RA 0.64, other RDs 0.76
🔸RFs assoc'd w/1st HZV infection
📌#SLE dx, serum albumin, serum creatinine; ⬆lympho/neutro ratio, CYC & Prednisolone use
@RheumNow #ACR21 abs0862 https://t.co/TXRmoBBDXK
sheila RHEUMarampa ( View Tweet)
Don't stop hydroxychloroquine in SLE, even when doing well. Associated with ⬆️flare risk. x2 even when in remission. Abstr#0959 #ACR21 @RheumNow https://t.co/1gGx0V5oxk
Richard Conway RichardPAConway ( View Tweet)
CV events go down when #hydroxychloroqine dose goes up in SLE BUT only in non smokers. Maybe due to smoking attention of HCQ levels &/or smoking as a bigger risk for CV over rides HCQ dose? ⬇️cardiac events by 28% in non-smokers abst0871 #ACR21 @RheumNow #RheumPix https://t.co/XxgK7iRXWi
Janet Pope Janetbirdope ( View Tweet)
#ACR21 Rheum Secrets and Pearl
Lupus pernio on the nasal ala.
⭐️Lupus in the name, but this is #sarcoid and not same as perniosis (chillblains)
@Rheumnow https://t.co/r49yjkjsje
Eric Dein ericdeinmd ( View Tweet)
Plenary at #ACR21 Renal outcome Risk of minority patients with pediatric #lupus @rheumnow abst#0956
inpatient hospitalizations. https://t.co/HK8w246Dsn
Bella Mehta bella_mehta ( View Tweet)
#ACR21 Rheum Secrets and Pearls
High CRP - not a typical marker of SLE flare. Look for infection!
@Rheumnow https://t.co/g1Z6OHvANv
Eric Dein ericdeinmd ( View Tweet)
Elevated CRP? Dr. Kolfenbach reminds us that it is not typical of #SLE flares, rule out INFECTION!
@RheumNow #ACR21 #RheumTwitter #MedTwitter https://t.co/FnkPdZ8gSl
sheila RHEUMarampa ( View Tweet)
"We need to do more than improving quality of care to close the gap in racial disparities." - Dr. J Chang
Trends of adverse renal outcomes⬇️w/time in children hosp w/SLE. Improvements seen across racial/ethnic group, but black-white disparity persists abst#0956 #ACR21 @rheumnow https://t.co/HcOwQiKCb2
TheDaoIndex KDAO2011 ( View Tweet)
This slide 👇 from Dr. Mary Crow's lecture shows how 2 categories of autoantibodies with their distinct functions can allow for different therapeutic targets in #lupus
@RheumNow #ACR21 #rheumatology https://t.co/wkthvj21cE
sheila RHEUMarampa ( View Tweet)
#ACR21 Hench Lecture. Wonderful talks by Peggy Crow on #lupus pathogenesis. Tour de force since LE cells discovery. Potential sources of self-nucleic acids:
💠Endogeneous retroelements LINE-1
💠Mitochondria
💠Cell-derived nuclear debris (NETs, apoptotic)
@RheumNow https://t.co/TSdyqblYaA
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Great Hench Lecture from Peggy Crow at HSS! From LE Cell to Interferon: Deconstructing Lupus Pathogenesis
#ACR21 https://t.co/rUxiwKGFqm https://t.co/af2PKrFBv3
Links:
Dr. John Cush RheumNow ( View Tweet)
Obesity does not affect #SLE disease activity despite persistent ⬆️in CRP. From Toronto #lupus database #ACR21 abst#0864 @RheumNow https://t.co/4ZpAMaU0jk
Janet Pope Janetbirdope ( View Tweet)
Attaining low disease activity in #SLE ⬇️ mortality! More time in LLDAS = #lupus low disease activity state = ⬆️survival in >4000 pts with SLE. Also + was clinical remission on treatment CROT. Treat to a target has come to SLE @RheumNow #ACR21 abst0865 #ACRBest #RheumPix https://t.co/8ld8oncFRR
Janet Pope Janetbirdope ( View Tweet)
