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Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com:
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There has been little science or evidence regarding the effects of COVID-19 infection on pregnancy and vice versa; and now the recent MMWR addresses the subject with two new reports
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The MIRROR study, an open-label pilot trial in refractory, uncontrolled gout patients, showed that pegloticase given in combination with methotrexate was safe and effective and maintained responses for 6 months after initiation.
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Dr. Rich Furie has lead a group of investIgators in reporting the significant efficacy of intravenous belimumab when added to standard of care induction therapy in patients with active lupus nephritis. This phase 3, 2-year study included 448 systemic lupus erythematosus patients with biopsy proven lupus nephritis (class III or IV +/- V) patients who required induction therapy and have a UPCR ≥1 g/g.
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Data from the Framingham Heart Study has shown that hip fracture incidence has decreased over time, probably resulting from improved lifestyle changes (less smoking and heavy drinking).
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JAMA Internal Medicine reports on a controlled clinical trial of knee osteoarthritis patients wherein meloxicam responses were not significantly or clinically superior to placebo or CBT (after placebo).
Dr. John Cush
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As of 20 Sept, CDC reports total US COVID-19 deaths to be 198,754. In the last 7 days 281,490 new Cases. Trends flat averaging ~40,000 Cases per day and ~600-1100 deaths per day. https://t.co/CPLVhz6qeH
The Lancet Rheumatology
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In our September issue—Symmetric peripheral polyarthritis developed during SARS-CoV-2 infection https://t.co/IqHp2GMLao https://t.co/Prvw8OBTvH
HCPLive
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Lisa Sammaritano, MD, stresses that there must be communication between rheumatologists and OB-GYNs when it comes to addressing pregnancy for #rheumatology patients.
#CCREast
https://t.co/j1IH6gsKnk
Bella Mehta
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Thank you all who participated in the survey. Here are some of our results
#Covid_19 #rheumatology https://t.co/55ETf6kK6T
Hosp Special Surgery
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Dr. S. Louis “Lou” Bridges, Jr. (@HSS_PIC) shares what led him to HSS and what he hopes to do as the Chief of the Division of Rheumatology. For more about Dr. Bridges visit https://t.co/oNiQxlLFeP. https://t.co/2vcLwUZJYQ
HCPLive
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"It’s a very difficult transition for providers to care for patients without a physical exam." #rheumatology #telemedicine @DartmouthHitch
https://t.co/ZSHmVqXDaT
Dr. John Cush
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The RheumNow podcast is up! Lupus delights - Lupus & Diet, Drug induced lupus & brand new biologics for SLE. Good news on immunosuppressives, colchicine and baricitinib in COVID-19 patients. . Watch it here https://t.co/Ymsd3eXN5d or listen to the podcast https://t.co/20FOr3qu3X
Dr. John Cush
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Lupus Delights
https://t.co/20FOr3qu3X https://t.co/AdRoaLDAmt
Dr. John Cush
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Doximity's 2020 State of Telemedicine report shows the top 10 specialties using telemedicine: 1. Endocrinology; 2. Rheumatology; 3. Gastroenterology, followed by Nephrology Cardiology GU Neurology Geriatrics Heme/onc Pulmonology https://t.co/J4Dt24ZlYg
Dr. John Cush
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Nurses' Health Study (79,568 women) examined the role of diet in 194 incident SLE cases and showed that diets (DASH, Meditteranean, antiinflammatory & healthy diets) had no significant effect of dietary quality on SLE risk https://t.co/JAFirjt0O8
Dr. John Cush
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NEJM report of 2 SLE pts treated w/ Daratumumab (anti-CD38) to deplete plasma cells a life-threatening refractory SLE. Clinical improvement associated w/ depletion of plasma cells, reduced IFN type I activity, down-regulation of T-cell transcripts https://t.co/K0fwpEHS81
Dr. John Cush
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COPDGene study of 361 DISH pts shows DISH carrieds a higher risk of coronary artery disease (OR 1.37 [1.05-1.78] (p=0.019), as measured by coronary calcium scores: 8.8% had CAC = 0; 12.8% CAC1-100; 20.0% CAC100-400 and 24.7% had a CAC>400. https://t.co/av1O907izH
Dr. John Cush
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Retrospective cohort study of 213 IMID patients, 36.2% tested positive for COVID-19, who had no greater risk of hospitalized or ventilation and immunosuppressive use was not shown to worsened the course of disease (TNFi decreased risk of hospitalization) https://t.co/gmIXDJkLCt
Dr. John Cush
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Taiwan National Health population study of 650 SLE and non-SLE controls undergoing hip replacement. SLE did not incr risk of early prosthetic infx, but did incr risk of late superficial wound infection (11.4% vs. 5.5%, P = 0.01; HR = 2.37) https://t.co/ZRMB23XLCk
