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Dr Uma Mahadevan presents results of the 14 yr registry study of pregnancy in IBD (Crohn's &UC) 1431 pts on with no Rx, thiopurines, biologics or thiop+biologics, showed no rush of fetal malformation, but did have incr in spont abortions @RWCSmtg @UmaMahadevanIBD https://t.co/SVQ2q1mJNW
Dr. John Cush RheumNow ( View Tweet)
Cardiac and Cancer Signals Tofacitinib Safety Alert from FDA The FDA has notified healthcare professionals of a safety alert concerning tofacitinib (Xeljanz) when given to at-risk rheumatoid arthritis patients. https://t.co/RJD8CMouHK https://t.co/bipwWlIhiB

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Dr. John Cush RheumNow ( View Tweet)
Metanalysis of 3 cross-sectional & 2case-control studies shows that the risk of developing #RA is elevated in patients with Crohns colitis (RR = 3.14; 95% CI: 2.46–4.01) and ulcerative colitis (RR = 2.29; 95% CI: 1.76–2.97) https://t.co/TIpd6lh5IZ

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - When RA Meets UC Ulcerative Colitis is complicating RA therapy https://t.co/a0LPvqPe1t

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Dr. John Cush RheumNow ( View Tweet)

QD Clinic - Arthritis and Colitis https://t.co/U5NrQuIcrd https://t.co/LbuRy9pTIl

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Dr. John Cush RheumNow ( View Tweet)
Ehlers-Danlos Syndrome pts have higher association with GI conditions (IBS, etc OR =3.57), POTS & Autonomic dysfunction (OR=4.4), food allergy (OR= 3.9), CV complications (OR 6.1; MV dx, aortic aneurysm), longer hospitalizations (OR= 1.76) https://t.co/noobvrx0cQ

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Dr. John Cush RheumNow ( View Tweet)

UTSW Rheum Grand Rounds - IgG4 Dz commonly presents as major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal (mass) fibrosis or tubulointerstitial nephritis. @UTSWIMchief

Dr. John Cush RheumNow ( View Tweet)

steroid prednisone lab

Corticosteroid Use Hikes CV Risks in Rheumatic Patients

d Jack Cush, MD

UK Clinical Practice Research Datalink population study shows that patients with immune-mediated inflammatory diseases, such as RA, PMR, GCA and IBD, have an augmented risk of CV outcomes with glucocorticoid use; even lower doses had a near doubling of their underlying CVD risk.

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#BestACR20Tweets RT @doctorRBC : AxSpa pts had Significant Gut Microbiome Differences in: 1⃣Disease activity and duration 2⃣Enthesitis 3⃣Radiographic involvement Abs#1853 https://t.co/ynemrgsP3W
Dr. John Cush RheumNow ( View Tweet)
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PIANO Study - Safety of Biologics in Pregnancy

d Jack Cush, MD

The results of the long awaited PIANO study have been reported in the journal Gastroenterology, showing that pregnant women with IBD may safely receive biologic or thiopurine therapy throughout the pregnancy without substantial added risk to the unborn or mother.

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Hypophosphatasia - CPPD/chondrocal, enthesop'y, DISH, exostoses - DDx of Low ALP: milk-alkali, Vit D intoxic'n, Wilson dz, via C def, celiac dz, adyn renal osteodystrophy, Cushing dz, hypothyroid, major sx, MM Rx - asfotase alpha- bone targeted replac't Rx #ACR20 #ACRambassador https://t.co/FJ1355MdKG
Vaneet K Sandhu, MD vksandhumd ( View Tweet)
In patients with Crohn's disease (CD), the presence of HLA-B27 and higher clinical activity of CD were associated with presence of SpA. SpA was present in 21% of early CD patients @RheumNow #ACR20 Abstr#1308

Dr. Antoni Chan synovialjoints ( View Tweet)

Minimum Clinically Important Improvement in Patients with Rheumatoid Arthritis Associates with Gut Microbiome https://t.co/D3ILR57gXY #RA #microbiome that microbiome again

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Peter Nash drpnash ( View Tweet)

Liver damage is NOT an extra-articular manifestation of RA BUT the ff'g factors are associated with liver disease in RA & can complicate management👇@RheumNow #ACR20 https://t.co/RqL69iVJpC
sheila RHEUMarampa ( View Tweet)
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RheumNow Podcast – ACR 20 is Coming to Town (10.30.20)

d Jack Cush, MD

Dr Jack Cush overviews the RheumNow commitment, upcoming bonus coverage of ACR20 and the good news and journal reports from the past week on RheumNow.com

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Vedolizumab Promising in Immune-Related GI Events

d Jack Cush, MD

Vedolizumab (Entyvio) was superior to infliximab (Remicade) for treating immune-mediated diarrhea and colitis (IMDC), a researcher reported.

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RheumNow Podcast – Back Talk: Questions from Listeners (10.23.20)

d Jack Cush, MD

Dr. Jack Cush reviews the news, journal reports, survey results and "Back Talk" questions from Rheums.

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Lilly has announced results of Phase 2 SERENITY trial showing the IL-23 inhibitor, mirikizumab, was more effective than PBO at week 12 (PRO and endoscopic outcomes) in moderate to severe active Crohn's disease. Efficacy continued out to week 52 https://t.co/n8Mdeonmas

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Dr. John Cush RheumNow ( View Tweet)

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

d Jack Cush, MD

A study of oral microbiome in anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals without synovitis (CCP+at risk) shows dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls.

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2020 Nobel Prize in Medicine Goes to the Discovery of Hepatitis C

d Jack Cush, MD

The Nobel Assembly at Karolinska Institutet has awarded the 2020 Nobel Prize in Physiology or Medicine jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice for the discovery of Hepatitis C virus. These three scientists made a decisive contribution to the fight against blood-borne hepatitis C, a major global health problem that causes cirrhosis and liver cancer in people around the world.

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