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Dr. Jack Cush Reviews the news and journal reports from the past week in RheumNow.com.
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ACR Open Rheumatology reports that systemic lupus erythematosus (SLE) patients have a higher risk of postoperative major adverse cardiac events (MACE) that can be identified by common cardiac risk measures.
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A prospective, longitudinal systemic lupus erythematosus (SLE) cohort study examined outcomes and showed that failure to control SLE was common and associated with poorer outcomes including organ damage, glucocorticoid exposure, poor quality of life, and increased mortality.
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The NEJM reports that systemic lupus erythematosus (SLE) patients treated with iberdomide, a cereblon modulator, was effective at yielding a significant SRI-4 clinical response after 24 weeks.
Dr. John Cush
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ICYMI: Montreal General Hosp SLE cohort study of 489 SLE pts - 35% have Raynauds phenomena; RP in SLE assoc. w/ Female (OR 2.43), White (OR 1.85), CNS disease (OR 1.98), RNP Abs (OR 3.0); negatively assoc w/ hemolytic anemia & cellular casts https://t.co/5t3GL4jqrm https://t.co/gVVqccvtca
Dr. John Cush
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New podcast available on Lupus worries. Download wherever you get your podcasts.
https://t.co/gU1mmRXYUi https://t.co/54IDshqNYd
Dr. John Cush
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Poor Outcomes in Lupus Patients Not at Target
A prospective, longitudinal SLE cohort study examined outcomes and showed that failure to control SLE was common/associated with poorer outcomes including organ damage, glucocorticoid exposure, and more.
https://t.co/wQMmPgbmWF https://t.co/ROeZU56cfy
Dr. John Cush
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Montreal General Hosp SLE cohort study of 489 SLE pts - 35% have Raynauds phenomena; RP in SLE assoc. w/ Female (OR 2.43), White (OR 1.85), CNS disease (OR 1.98), RNP Abs (OR 3.0); negatively assoc w/ hemolytic anemia & cellular casts https://t.co/dUxAAIIyya https://t.co/ttIt9pDsTh
Janet Pope
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#ClinicalPearl #Lupus nephritis is often now START w 2 immune suppressive & less total dose of #prednisone & May pulse w 500 mg solumedrol x3 instead of 1g. J Merrill #RNL2022 @RheumNow https://t.co/ePKkPHWhYJ
Robert B Chao, MD
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Dr. Peter Lipsky on the "Almighty ANA"
"There are 45 million people out there with a +ANA. It is not a good screening tool."
@RheumNow #RNL2022 https://t.co/Xtu7kUzd6K
Nouf Al hemmadi
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ANA
▶️Short lived plasma cell DNA.
▶️Long lived plasma cell ANA RNP.
Peter Lipsky @rhumnow #Rnl2022 https://t.co/U7YkCBEEFJ
Janet Pope
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#ClinicalPearl Urinary biomarkers for #SLE #nephritis are still mostly too ‘dilute’ for prime time. Albumin/creative spot urine and #microalbuminuria are still v Impt @RheumNow #RNL2022 https://t.co/uEWs0saSX3
Nouf Al hemmadi
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Lupus heterogeneity:
Anti Smith Anti RNP more common in certain ethnicity , more interferon production and aggressive disease!!!
Peter Lipsky @rhumnow #Rnl2022 https://t.co/xGhafD4l8k
Nouf Al hemmadi
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HEp-2 cell and ACR classification criteria:
Peter Lipsky @rhumnow #Rnl2022 https://t.co/6o6epkjqB4
Nouf Al hemmadi
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Avoid screening with ANA, PLEASE!!
Normal postive ANA
Peter Lipsky @rhumnow #Rnl2022 https://t.co/GEKmhQfpfm
Elena MyasoedovaMD
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Remarkable heterogeneity in results of #ANA testing using different assays #PeterLipsky on “Almighty ANA” at #RNL2022 @RheumNow https://t.co/A0y3ugBBrz
madan
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ANA levels fluctuate & depend on the https://t.co/rjZhNvSzE1 should we use it as an entry criterion to diagnose lupus ? #RNL2022
Nouf Al hemmadi
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ANA in otherwise healthy:
Anti-DFS70 antibodies (Dense Fine Speckled, 70kDa molecular weight) are a sub-group of anti-nuclear antibodies.
Peter Lipsky @rhumnow #Rnl2022 https://t.co/QH4qsdzZmu
Nouf Al hemmadi
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Q and A
Positive ANA post COVID infection and vaccination?
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1- Repeat test ( transient elevation).
2-Monitor clinical symptoms.
PS, COVID infection ▶️lupus anti coagulant and catastrophic APS like syndrome.
@RheumNow #Rnl2022
Nouf Al hemmadi
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ANA variability among different platforms and essays.
Validated quantification test are needed!!
Peter Lipsky @rhumnow #rnl2022 https://t.co/pyJhBkJE8P
