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MMWR study of shows 2 dose mRNA COVID vax during pregnancy was 61% effective preventing infant COVID. Among 176 infants hosp w/ COVID-19, 84% were born to mothers who were not vaccinated during pregnancy.https://t.co/mWgHHcL05u

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: MMWR reports >40,000 pregnant women who received COVID-19 vaccination during pregnancy- VAX not associated with preterm birth or small-for-gestational-age at birth overall compared with unvaccinated pregnant women. https://t.co/GtRMsNrFnn

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Dr. John Cush RheumNow ( View Tweet)

pregnancy,doctor,consult

COVID-19 in Pregnant Rheumatic Women

d Jack Cush, MD

The Global Rheumatology Alliance (GRA) has studied the outcomes of women with rheumatic disease who were pregnant at the time of infection with coronavirus disease 2019 (COVID-19).

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Best of 2021: Jack of All Subspecialties

d Jack Cush, MD

It's great to be a rheumatologist, but boy, it's getting harder and harder. You have to be a jack of all trades. You have to be good at cardiovascular disease, osteoporosis, vaccination, inflammatory bowel disease - it just never ends. This and more, as Dr. Cush summarizes more than a dozen journal articles, news reports and questions + cases.

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Best of 2021: Tofacitinib Safety Concerns

d Jack Cush, MD

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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fetus,defect,baby,malformation

Best of 2021: Potential Birth Defects with Hydroxychloroquine

d Jack Cush, MD

HCQ is one of the safest meds used in rheumatology, but new claims data suggests a small increase in the risk of malformations associated with first-trimester HCQ use. The March 2021 issue of the American Journal of Obstetrics and Gynecology studied the risk of major congenital malformations during the first trimester of pregnancy in women with rheumatic disease taking HCQ.

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Indications Awaiting (12.17.21)

d Jack Cush, MD

There's good news and bad news in rheumatology fellowship matching for 2022.  There's also new FDA approvals and indications, but a new serious safety warning has arisen from the CDC about the J&J COVID-19 vaccine. 

Dr. Jack Cush reviews the latest news, journal reports, regulatory approvals, plus 3 new cases from rheumatologists.

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Pregnancy Outcomes in PsA, SpA, RA: Dr. Rachel Tate ( @uptoTate) reviews abstracts #0369, #1722 and #1730 presented at the ACR21 annual meeting. https://t.co/kUQReWtEdO https://t.co/MZ9Fe1Ms3N

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Dr. John Cush RheumNow ( View Tweet)
Infection Risk in Offspring Exposed to Biologics: Dr. Rachel Tate ( @uptoTate) https://t.co/oYpKpCix7Q https://t.co/0yIk9Qhc1h

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Dr. John Cush RheumNow ( View Tweet)
rachel.tate

Safety of Psoriatic Biologics in Pregnancy

d Jack Cush, MD

Little is known about the safety of newer biologic use during pregnancy, especially in patients who either conceive while on a biologic or must remain on a biologic during pregnancy (often the case with IBD and inflammatory arthritis).

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SpA & Pregnancy Outcomes? ➡️SpA pts txed w/ bDMARDs at conception are not at higher risk for adverse pregnancy outcomes compared to those w/o bDMARD ➡️Stopping bDMARDs after conception assoc w/ ↑ dz activity during pregnancy + after birth & ↑flares Abst#1730 #ACR21 @RheumNow https://t.co/Y4c7vI0cgS
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
RHEKISS registry: SpA pts on bDMARDs at conception are NOT at inc. risk for adverse pregnancy outcomes. Discontinuation of bDMARDs after conception is assoc'd w/ inc. dz activity during/after pregnancy & flare risk. Abs 1730 #ACR21 #RheumNow @RheumNow https://t.co/b2wI9GZios https://t.co/wsuvv3hF0v

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Dr. Rachel Tate uptoTate ( View Tweet)
Pregnant pts w/ PsA, but not AxSpA, at increased risk of pre-eclampsia. In RA pregnancies, pre-eclampsia risk increases w/ dz severity prior/during pregnancy. We need to discuss potential risks w/ pts and OB team. Abs 1722 #ACR21 #RheumNow @RheumNow https://t.co/yeQmNAZ1jV https://t.co/cBfeVKQHfr

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Dr. Rachel Tate uptoTate ( View Tweet)
No clear excess risk for offspring exposed in-utero to, VED or TNFi's. UST showed infection signal BUT w/ wide CIs. We need more research re: biologics and placental transmission potential/subsequent risks. Abs 1713 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/W3K5uDyHlC

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Dr. Rachel Tate uptoTate ( View Tweet)

#ACR21 #Abstr1492 Could gut microbiome contribute to Anti-Ro+/autoimmunity in #lupus? Analyses of 125 stool samples from mother of children with neonatal lupus and/or heart block revealed its potential role in genetic-environment interaction @RheumNow https://t.co/FnJtZJSCRj https://t.co/ttRdP9NIrG

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
ACR Best

ACR21 Best Abstracts - Day 1

d Jack Cush, MD

The RheumNow faculty have been glued to their monitors all day, watching video, and running down abstract presentations to find the best – several of these stood out as #ACRBests. Here is a listing of “Best” they saw on Day 1.

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Meds men with rheum dz can use while trying to getting their partners pregnant #acr21 ⁦@RheumNow⁩ https://t.co/RlcPakappk
TheDaoIndex KDAO2011 ( View Tweet)
Review of ACR Reproductive Guidelines by Dr. Talabi #ACR21 #ACRAmbassador https://t.co/x2xCSnxpJ2
Veena Katikineni VeenaRheumMD ( View Tweet)
"Healthier moms lead to healthier babies. This is how I frame the discussion regarding medications and PsA in my practice (with regard to reproductive health)." Dr. Talabi #ACR21 @RheumNow #RheumNow

Dr. Rachel Tate uptoTate ( View Tweet)

Dr B Bermas noted AAP guidelines say avoid MTX while breastfeeding, but the literature show very little MTX crosses breast milk. Dr Sammaritano stated that is true, but we don’t know how much MTX accumulates,though. #acr21 @rheumnow @UTSWRheum https://t.co/9I7HszorEO
TheDaoIndex KDAO2011 ( View Tweet)

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