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ACR20 - Day 2 Report
Saturday was the day 2 with many posters and live sessions at the 2020 Virtual ACR/ARP meeting. Here are a few of my highlights from day two:
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Herpes Zoster Events with Anifrolumab in Patients with Active SLE: An Integrated Analysis of Phase 2 and Phase 3 Trials https://t.co/70oOHXihFb #SLE #zoster x 4-5 times increase in zoster
Peter Nash drpnash ( View Tweet)
@jhrheumatology Michelle Petri MD MPH: thrombosis risk composite score = Low C3 + dRVVT + Platelet C4d. Abst#1513. PltC4d associated with proteinuria, venous/arterial thrombosis. #ACR20 @RheumNow https://t.co/OdAjul5Usg
Eric Dein ejdein1 ( View Tweet)
@andreafava @jhrheumatology shows class switch is common in lupus nephritis biopsy, chronicity scores are critical. Shows value of need for liquid biopsy @rheumnow #ACR20 Abst#1512 https://t.co/M0DWmTLP29
Eric Dein ejdein1 ( View Tweet)
Dr. Crow's #StateoftheArt lecture revealed that BEL may be best used in pts with < 2 years and SLEDAI >10 based on the study from Gatto, M et al from 2020. Does this change how you will use BEL in your practice? #ACR20 @RheumNow
Dr. Rachel Tate uptoTate ( View Tweet)
We were always taught that rheumatic disease ILD is v bad in pregnancy.
Fetal outcomes are def bad in severe ILD, but no maternal deaths/few Cx.
May not need to avoid pregnancy/electively terminate!
Largest-to-date cohort @dukemedicine n=94
@drbags71 #ACR20 ABST1446 @RheumNow https://t.co/E7BDHn8KJb
David Liew drdavidliew ( View Tweet)
This study identified novel RFs for RA-ILD:
Obesity
⬆CRP(≥10mg/L)
Poor function(MDHAQ ≥1)
High education
30py smoking hx assoc'd w/⬆ RA-ILD risk
Do u counsel RA pts on smoking cessation & lifestyle change? @Rheumnow #ACR20 abs1198 #ACRbest @jeffsparks https://t.co/jvZ26n8k5p
sheila RHEUMarampa ( View Tweet)
Another interesting paper looking at screening of AxSpA in AAU patients with chronic back pain. At least 64% patients had confirmed or suspected AxSpA @RheumNow #ACR20 Abstr#1306
Dr. Antoni Chan synovialjoints ( View Tweet)
John Stone: "The HISTORY is the Rheumatologist's scalpel." TA bx is not gold standard in diagnosis, as not fully sensitive. @RheumNow #ACR20.
Eric Dein ejdein1 ( View Tweet)
Nurses Health Study results - live healthy & 40% less chance of Getting #SLE #lupus. Not an easy recipe - diet in top 40%, never smoking, regular exercise, modest ETOH, normal BMI. Abstr#1473 Maybe that is why SLE is in the rise Abstr#0274 @RheumNow @CRASCRRheum https://t.co/qYCkYC6Mqq
Janet Pope Janetbirdope ( View Tweet)
#ACR20 Dr. M. Crow on Lupus #StateofArtLecture reviews treatment of SLE:
1. HCQ is the foundation of Rx
2. keep pred <7.5mg/day
3. belimumab works better when given early in disease (<2 yrs)
4. combination Rx may be needed
@rheumnow https://t.co/6zh1xkLXgN
k dao KDAO2011 ( View Tweet)
So much more work to be done- the traditional tools for estimating CVD in rheumatic patients are likely not accurate especially patients with SLE- abstract 1286 @RheumNow #acr20 https://t.co/L6Z1fsO2he
alexa meara lexmeara ( View Tweet)
Dr @AliDuarteMD presents on incidence of SLE over last 40 years, 29% increase overall, and doubled in males. Overall cyclical pattern. Abstr#1024 #ACR20 @rheumnow https://t.co/SSVY0U0SIg
Richard Conway RichardPAConway ( View Tweet)
Another addition to "Where you live matters!" NYC principal component analysis of 140 neighborhood characteristics show - location and SES influence incidence and severity of #COVID19 in #SLE @rheumnow #ACR20 ABS#0984
Bella Mehta bella_mehta ( View Tweet)
Toll-like Receptor Inhibitor Peptide Improves the Clinical, Immunologic, and Pathologic Manifestations of Systemic Lupus Erythematosus https://t.co/hAqngljp2b #sle #tollreceptorinhib TLR inhib in mice for SLE
Peter Nash drpnash ( View Tweet)
TMA and SLE by Dr Levy @SickKidsNews
👉TMA triad - microangiopathic hemolytic anemia, thrombocytopenia, impaired renal function
👉TTP pentad - fever, thrombocytopenia, hemolytic anemia, renal impairment, neurologic involvement
#ACR20 #ACRambassador https://t.co/xnO1JkhSFT
Herman Tam DrPedsRheum ( View Tweet)
Neighbourhood characteristics & socioeconomic factors important not only for contracting #COVID19 but also severe infection in #SLE. Results useful for developing strategies to address socioeconomic stressors in this population.
Abs#0984 #ACR20 @RheumNow
https://t.co/u4YDcfEcSQ
Mrinalini Dey DrMiniDey ( View Tweet)
Time-trend analysis in hospitalised #infection in #lupus
-Incr. rate of hospitalised infections over time
-#Sepsis surpassed #pneumonia as most common hospitalised infection in 2011-12; twice as many sepsis vs pneumonia by 2015-16
Abs#0980 #ACR20 @RheumNow
https://t.co/M8xbMDFUTS https://t.co/ShogvxbhzN
Mrinalini Dey DrMiniDey ( View Tweet)
Withdrawal of MMF may be safely in #SLE patients in remission #ACR20 @RheumNow Dr Chakravarty https://t.co/xnpagKNu96
Sole RetamozoSole ( View Tweet)
Dr Joan Merrill presents a phase 2 trial
use of Iberdomide in patients with #SLE
-Novel MOA —> blocks TF Ailos and Ikaros
Conclusion
-Primary end point was met at week 24
-Effects greater in Aiolos high/Type 2 IFN high
-Iverdomdie was tolerated well
#Lupus
#ACR20
#ACRambassador https://t.co/zpQR9ceV7p
Mohammad A. Ursani MD, RhMSUS DrMAUrsani ( View Tweet)
