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Hip Fractures Increased in Rheumatoid Arthritis
An analysis of 741,589 patients over age 45 years from southern Swedish registry examined patients who were followed (between 1998 and 2012) until a hip fracture, death or exit from the region occurred.
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Diffuse Alveolar Hemorrhage in Lupus Reviewed
Diffuse alveolar hemorrhage (DAH) is a rare but catastrophic complication of systemic lupus erythematosus. Presentations are usually acute and the potential for significant morbidity and mortality risk mandates early diagnosis and aggressive interventions.
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Physicians Bash Meaningful Use at Open Forum
Members of two professional medical societies griped about what they view as the Obama administration's inept attempts to regulate electronic health records (EHRs) and shared their visions for the ideal online platform at a second "town hall" meeting here Tuesday.
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Brodalumab vs. Ustekinumab: Head-to-Head Studies of Psoriasis
AMAGINE-2 and AMAGINE-3 are in two phase 3 studies that compare multiple doses of brodalumab (anti-IL-17) and ustekinumab (anti-12/23) in adults with moderate-to-severe psoriasis.
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Ustekinumab Effective in Adolescents with Psoriasis
Biologic and new drug development seldom targets children and adolescents. This study evaluated the efficacy and safety of ustekinumab in adolescents age 12 to 17 years with moderate-to-severe psoriasis,
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TICOPA Study: Tight Control in Psoriatic Arthritis
Tight control in rheumatoid arthritis was introduced with the TICORA trial and validated in numerous treat-to-target studies since. Now the benefits of tight control in psoriatic arthritis (PsA) have been reported.
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Health Hazards of Fructose and Soda
The health consequences of fructose-containing sugars, sucrose and high fructose corn syrup, found in sugar-sweetened beverages and foods, may be numerous and include obesity, type 2 diabetes, gout and cardiovascular disease.
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Rheumatoid Arthritis Associated with More Severe Acute Coronary Syndromes and Outcomes
Acute coronary syndromes (ACSs), myocardial infarctions and heart failure appear to be a hazardous consequence to systemic and articular inflammation in rheumatoid arthritis.
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Fibromyalgia Prevalence & Characteristics
PLOS has reported the results of the 2012 US National Health Interview Survey that focuses on fibromyalgia.
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Future 2 Trial Shows Secukinumab Efficacy in Psoriatic Arthritis
Secukinumab (Cosentyx) is an anti-IL-17 monoclonal antibody currently approved for use in moderate to severe psoriasis. It has also been studied in psoriatic arthritis (PsA) and shown to be safe and effective.
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DAS28-CRP or DAS28-ESR: Are they Biosimilar?
The disease activity score (DAS28) has been developed as a dynamic assessment tool and a therapeutic response measure for use in clinical trials and practice.
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Diastolic Dysfunction in Rheumatoid Arthritis
Poor cardiovascular outcomes have been linked to inflammation and rheumatoid arthritis (RA). This includes higher rates of MI and heart failure (HF).
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A Controlled Trial of Yoga Benefits Arthritis Patients
Yoga and stretching appear to be important forms of exercise for patients with fibromyalgia, but their utility has seldom been explored in patients with rheumatoid or osteoarthritis.
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Is Early Use of TNFi in Spondyloarthritis Overkill or a Necessity?
Axial SpA (axSpA) is a chronic inflammatory disease that includes AS and non-radiographic axSpA (nr-axSpA).
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Age and Comorbidity Contribute to Higher Death Risk Following Hip Fracture Surgery
Patients undergoing surgery for a hip fracture appear to have higher death rates than those having elective total hip replacement.
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Funding for Rheumatology Research in Decline
The Rheumatology Research Foundation and Rheumatology News report that research projects funded by the National Institutes of Health (NIH) dropped by 52% from 2010 to 2014, while the number funded by private foundations fell by 29% over that period.
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Obesity Protects Men from Rheumatoid Arthritis
Researchers from Malmo, Sweden have analyzed data from 383 patients, taken from two population based health surveys with a total of 50,705 participants, and found there is a strong association between a high BMI in men and a lower risk of developing rheumatoid arthritis (RA).
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Higher Death Rates in Ankylosing Spondylitis
A nationwide study of 8600 ankylosing spondylitis (AS) patients from Sweden, compared survival to 40,460 controls between 2006-2012.
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SCOT Study Shows NSAID Safety
Since the 2005 FDA hearing that resulted in the removal of Vioxx and Bextra from the US market, the safety of nonselective NSAIDs (nsNSAIDs) and selective Cox-2 inhibitors (e.g., celecoxib) has been repeatedly questioned, often without new or substantive data.
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Romosozumab Surpasses Teraparitide in the STRUCTURE Study
The experimental bone drug, romosozumab, has succeeded in meeting its primary endpoint by showing it was significantly more effective than teriparatide in a 12-month study assessing total hip bone density in postmenopausal women with osteoporosis.
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