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DPGN, lupus, nephritis, GN, glomerulonephritis, biopsy, kidney

Racial/ethnic disparity in U.S. lupus nephritis mortality

Janet Pope, MD, MPH, FRCPC

At #ACR21, the plenary session included an analysis of deaths from SLE throughout the US comparing 1999 to 2019 (Abstract #0454).

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Psoriatic Arthritis: "What Matters" to Patients, Physicians

Swetha Ann Alexander, MD

A study presented today by Mease et al. addresses the vital gap between what patients and physicians consider disabling because of PsA, and emphasizes “what matters” in a daily clinical encounter while dealing with PsA.

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audience learn

Day 4 Report from ACR21

Jack Cush, MD

My favorite three presentations from day 4 (Tuesday) at ACR 2021 included the following.

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Malar,rash,SLE, Lupus

Predictors of Remission and Low Disease Activity in SLE

Sheila Reyes, MD

A treat-to-target strategy has been shown to improve clinical outcomes in patients with rheumatic diseases like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis including systemic lupus erythematosus.  The goal of treatment in SLE is aimed at remission or low disease activit

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ACR21 – Day 3 Report

Jack Cush, MD

Hitting the home stretch, day 3 presentations were big! Here are a few of my favorites: secukinumab efficacy in juvenile PsA; VEXAS - predicting poor outcomes; and the FDA Safety Update session.

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rare

Risks associated with mortality in VEXAS

Md Yuzaiful Md Yusof, MRCP(UK), PhD

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome (VEXAS) took the centre stage when it was first introduced at ACR20 last year. It got everyone’s thinking that they might have encountered one or two patients in their rheumatology lifetime who might have this condition.

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The Need for Comparative Treatment Trials in Psoriatic Arthritis

Richard Conway, MBBChBAO, PhD

Psoriatic arthritis is currently experiencing a burgeoning selection of treatment options. While this is a very welcome development in a disease which has had less treatment options compared to RA, it leaves us with a difficult conundrum: which agent to choose for an individual patient.

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Thank you @AhmadSherbini for discussing his #ACR21 research on @RheumNow on Abs#1444 - Can we predict which patients are most likely to have nausea or alopecia intolerance to MTX? https://t.co/I5WmCECq7v

Eric Dein ericdeinmd ( View Tweet)

Racial differences in PsA patients in large US real world database 95% Whites (W) and 5% were AA NSAIDs: 80% W and 78% AAs TNFI: 51% W and 41% of AAs DMARDs: 72% of W and 98% of AAs HTN/DM/Obesity/Gout 🔼 AA Cancer/osteoporosis /anxiety 🔼 whites Abst#1780 #ACR21 @Rheumnow https://t.co/7ee4bVU7ZA
swethaann23 swethaann23 ( View Tweet)
Racial disparities & Co-morbidities in PsA findings. Amongst important others, increased biologic use in Caucasians w/ PsA vs DMARDs in black PsA pts. View Abs 1780 for other relevant findings. #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/0uKsa8i0bG https://t.co/R9YkxYqXws

Links:

Dr. Rachel Tate uptoTate ( View Tweet)
Minority (African American and Hispanic) #SLE patients have worse #COVID19 outcomes – double whammy! Data from the @rheum_covid #ACR21 @rheumnow #abst1933

Bella Mehta bella_mehta ( View Tweet)

#SLE patients with limited health literacy affects vulnerable black patients in multiple domains – worse disease activity/damage, physician/patient communication, worse patient centered care, and patient activation @mithurheum #ACR21 @rheumnow #ACRBest abst#L08

Bella Mehta bella_mehta ( View Tweet)

Will a FDA black box warning change your JAKi practice? In May 2019, the EMA put out a warning about VTE with tofacitinib. In this French cohort, did it change the kind of pts they initiated on JAKi? no, not it did not😊 A window into the US future? #ACR21 ABST1245 @RheumNow https://t.co/QI95E1gepg
David Liew drdavidliew ( View Tweet)
#ACR21 #Abstr0768 We need to improve disparity among all levels of income. Support to the lowest income group seemed to improve but children with #lupus who were in the 2nd level income quartile had the longest length of stay in the hospital #RheumNow https://t.co/7HSveerUhs https://t.co/cSQBELopH5

Links:

Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Meta-analysis from @rheum_covid with @HsiehEvelyn shows that people with rheumatic disease are at⬆️risk of SARS-CoV-2 infection and⬆️mortality from COVID-19. Abstr#0086 #ACR21 @RheumNow #ACRBest https://t.co/B7tWs02gfc
Richard Conway RichardPAConway ( View Tweet)
CARRA survey in SAID pts reported no change in flare frequency w/ COVID19 but many had reduced intensity of fevers during flares. Majority of pts reported mild to moderate symptoms w/ 1/3 had lingering COVID19 symptoms. Abs 1083 #RheumNow #ACR21 @RheumNow https://t.co/qbfsqvXutt https://t.co/6u33VDIexY

Links:

Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Petri on SLE, Vit D, and BMD ~1k pts, 92% fem, 42% Black, 48% White Freq. of osteoporosis: 💠M ~ F 💠Black ~ White 💠⬆️in smokers Lumbar BMDs showed: 💠Vit D level w/Paradoxical effect 💠Rec goal of 40ng/mL in SLE https://t.co/kBylQAwqhD #ACR21 Abst#1265 #ACRBest @RheumNow

Links:

Pedro Castillo _Castillo_Pedro ( View Tweet)

@LianneGensler Is exercise anti-inflammatory? In this study, healthy volunteers were infused with E coli endotoxin 😲 and their TNF levels measured. TNF levels were compared between groups at rest and groups exercising. TNF levels were ⬇ by exercise. #ACR21 https://t.co/Ylw7SQX32y
Rheum Cat rheum_cat ( View Tweet)
#ACR21 Ab#1445. RTX & #covid19 outcomes ⭐️RTX ass. w/ Upwards arrow COVID hospitalization, ICU admission, and ventilation ▶️We need huge caution in pts that have not been vax'ed before RTX 💉💉 @Rheumnow https://t.co/6UNUVhnBkI https://t.co/vHkQe9fZpI

Links:

Eric Dein ericdeinmd ( View Tweet)
JAK-pot registry-based study. Following JAKi failure should you switch mode of action or go to second JAKi? Both seem equally effective in terms of drug retention. Didn't matter if switch for efficacy or adverse event. Abstr#1442 #ACR21 @RheumNow https://t.co/QEBB3flArC
Richard Conway RichardPAConway ( View Tweet)
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