While COVID vaccination and subsequent booster remain the cornerstone, pre-exposure prophylaxis such as Evusheld (tixagevimab and cilgavimab) has been approved by FDA in December 2021 and EMA in March 2022 for people immunocompromised either due to a medical condition or receiving treatment with immunosuppressants and may not mount an adequate immune response to COVID vaccination. How does this therapy fare in RMD patients?
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Is there finally something new on the horizon in Sjogren’s syndrome?
Patricia Harkins
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Congenital ❤️ Block in Ro/La pregnancies
Abst#0957
👉1st echo @ mean 20wk
👉CHB 3/47- all on 1st echo
👉 1 reversed 3rd ➡️ 1st AVB post dexamethasone
🔥Key messages🔥
🤰serial echo should start @ 16-18wk gestation
👶 early detection ⬆️ outcomes
#ACR22 @RheumNow
#ACR22 Plenary II Abstr#1114 Access to therapy/Cost need to be improved since high copays (=> 10USD per month) affects adherence to treatment (HCQ, AZA, MMF but not MTX) in #lupus @RheumNow https://t.co/WnwIhpqDxL
David Liew
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"If I had one test in a difficult case of suspected PMR, it would be PET/CT" - @LCalabreseDO
#ACR22 @RheumNow
(credit: as heard by @drceowen) https://t.co/w88peUd4j1
Patricia Harkins
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Mx aging rheumatic dx pt
🌟5M approach🌟
🧠Mind (mood/cog)
💊 Medication (polypharm)
🏃 Mobility
👉Multicomplexity (biopsychsoc)
💪🏻 Matters (aligning 2 specific goals)
💥Interdisciplinary💥
#GeriRheum #ACR22 @RheumNow @B_Buehring_MD @UnaMakris
DANBIO registry plenary Abs 1112 finds 1 yr retention following a mandatory nationwide infliximab biosimilar-to-biosimilar switch was high. Retention higher in originator-experienced and in pts w/ low disease activity. #ACR22 @RheumNow https://t.co/ZAV2dcVzXl https://t.co/Kti2bZ1pkZ
#ACR22 Plenary II. Abstr#1113 Promising news in #Sjogren. Phase 2 RCT showed oral BTK-i Remibrutinib improved ESSDAI score vs Placebo (delta -2.8) & salivary flow at Wks 24. ESSPRI unchanged. No major safety concern. Look forward to Phase 3 results soon @RheumNow #ACRBest https://t.co/z0oy9FvheY
Sjogren's in a Plenary! Remibrutinib (BTKi) in SjS
Improved ESSDAI at wk 24, but NONE on ESSPRI (more patient-centric ie fatigue, dryness, joint pain)
Definitely helps w/lab abnormalities, but worried benefit for outcomes that matter may be limited
#ACR22 @RheumNow abstr#1113 https://t.co/GutY8KndbR
Fabio Torres
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@EBRheum @RheumNow Its more than that…tubulointerstitial kidney disease, lymph nodes, salivary gland, and hepatobiliary tract disease don’t show findings of vasculitis.
Certain HLA haplotypes more linked with autoimmune diseases are present.
#ACR
@RheumNow
Presence of DFS pattern should not be used to indiscriminately exclude presence of a rheumatic disease based on retrospective study in Abs 0814. RA, SS and Raynaud's ICD10 codes were higher among DFS pattern ANA per chart review. #ACR22 @RheumNow https://t.co/mLtppvR4dk https://t.co/6Lukxntqe7
CreakyJoints.org
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Dr. Jack Cush discusses uptake of #telemedicine in 2020 and the relative decline of uptake since then:
@RheumNow -- What's your take on continuing to use #telehealth for rheum visits? #ACR22 https://t.co/OB5Wnnq6Fh
CreakyJoints.org
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“Go digital or go home” -- Dr Jack Cush says on #telemedicine in a session at #ACR22 @RheumNow https://t.co/4PzGgS900t
sheila
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Dr. Megan Clowse gives 2 major tips on how rheumatologists can help avoid catastrophic pregnancies:
✳️Routinely ask open-ended Qs to promote HONEST dialogue about repro health
✳️Provide ACCURATE info & guidance using discussion guides and handouts
#ACR22 @RheumNow @rheumarhyme https://t.co/qXwKMdJmR8
Akhil Sood MD
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Advancing Telemedicine in Rheumatology
'We all became Zoomatologists (Zheum-atologists?) since COVID.' -Jack Cush @RheumNow
@RheumNow #ACR22
Pts w/ pre-existing rheumatic conditions 3.6 times likelier to new rheumatic disease features or worsening disease after starting ICI for melanoma, Abs 0756 #ACR22 @RheumNow https://t.co/s1f1QxmJzA https://t.co/6cKllBzqJn
Stop repeating the #ANA test!
46% of all ANA tests were repeat tests in this study. #HealthCareCost #NoUtility #ChooseWisely abst#1278 @rheumnow #ACR22 https://t.co/K7oyqJYvi9
Akhil Sood MD
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#ACR22 Advancing Telemedicine in Rheumatology
'60% prefer telemedicine for routine visits and review lab results'
https://t.co/HUgoocXodE
@RheumNow #ACR22
#abs0948 #acr22 @rheumnow perception on fertility&ART in pts w/rheum Dx: 60% believe their Dx affects fertility/25% believe meds do: most cited MTX, steroids, TNFi, HCQ, NSAIDs. 92% heard of ART but unsure if safe or successful w/their Dx. Hx of infertility 29%/only 52% go w/ART https://t.co/lmaM773gP5
Abs 0698 at #ACR22 finds that a 20 pack-year or more of cigarette smoking assoc'd w/ a modestly higher risk of incident PMR among women. Yet another reason to encourage smoking cessation in patients. @RheumNow https://t.co/HOVTIPSjOi https://t.co/Akuukxb90Q


