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Top 5 Clinical Pearls in RA Management
RheumNow Live 2024 provided a wealth of clinical insights, particularly in the realm of rheumatoid arthritis (RA) management. Here are the top five clinical pearls from the event's opening session, "Success in Rheumatoid Arthritis."
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APIPPRA Trial: Abatacept in at-risk rheumatoid arthritis patients
Abatacept has been studied in seropositive clinically suspect arthralgia patients (at risk for rheumatoid arthritis) and shows the potential to delay or prevent the disease.
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Could Weight-Loss Drug Improve Hip Replacement Outcomes?
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MedPage Today
The antidiabetic and weight-loss drug semaglutide (Ozempic, Wegovy, Rybelsus) either does or does not help patients undergoing total hip arthroplasty (THA) avoid complications and other poor outcomes, according to two retrospective studies presented here.
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Oral IL-23 Inhibitor Effective in Psoriasis
The NEJM has published the results of the FRONTIER 1 trial demonstrating the efficacy of JNJ-77242113, an oral interleukin-23 (IL-23) receptor antagonist peptide, in patients with psoriasis (PSO).
https://t.co/9GjR6Vx3At https://t.co/tZiykNuzKS
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Mayo study of 1643 #RA pts (Dzduration 7 yrs) found 4 clusters based on # of comorbidities (Cluster 1 [42%] few comorbidities & cluster 4 [7%] > 10). Cluster 1 w/ good prog/survival; but cluster 4 was older, less DMARDs/biologics https://t.co/qAWZoXVWlv https://t.co/g3gMsNj848
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Retrospective cohort analysis of 330 psoriasis pts - 83 (25%) developed #PsA after mean of 36 (3.5–114) mos. PsA Predictive factors include being female (OR=3.33), nails involved (OR=5.4), severe PSO (OR=27.4), po systemic Rx prior to PsA (4.1) https://t.co/Hpn6f1EUfD https://t.co/QanJkNi5S6
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Sex Disparities in PsA/SpA
https://t.co/3pmFyo6Ztm https://t.co/zanPiI7GT5
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Retrospective study of non–small cell lung cancer(NSCLC) pts Rx w/ immune checkpoint inhibitor finds that those who develop immune-related AE (irAEs) (n=803) have improved overall survival (23.7 vs 9.8 mos survival; P < .001) https://t.co/yiwJZJU10W https://t.co/fwFFlf7Q6L
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Sarcoid arthritis (SA) seen in 19% of sarcoid pts. Metanalsysis of 49 articles (8574 pts) found Ankles most frequent (80%) followed by knees & wrists. Monoarthritis was uncommon (1%). Acute , 0-2, I2 55%). Acute SA (oligo & poly) was linked to E nodosum. https://t.co/XPbS4vVX9o https://t.co/CqonQ1a3wW
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In 551 juvenile myositis pts, 36% had myositis assoc Abs (MAA); 13% had >1 MAA. MAA+ pts had more overlap dz (18 vs 6%, p<.001) & assoc w/ Raynauds (OR 2.44), ILD (OR 3.43), chronic Dz (OR 1.72), mortality (OR 3.76). # MAAs was assoc w/ mortality (OR 1.83) https://t.co/gvHIEuiG66
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Study of 43 SSc patients w/ gangrene shows Smoking Hx ; positive-ACA, ANCA, APL Abs & high ESR were independent risk factors for digital gangrenes in SSc. Vasculitis and macrovascular disease may contribute to the progression of digital gangrene https://t.co/YmwurwymLb https://t.co/RiOIkbIEXM
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Transcriptome analysis (of PBMCs) looked for differential gene expression btwn 125 SJIA & 92 healthy controls identified 4 key genes (ALDH1A1, CEACAM1, YBX3 and SLC6A8) distinguishing SJIA; & may aid in diagnosis. https://t.co/M6pfajw3U3 https://t.co/VVwrYUJcBH
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#RWCS24
New diabetes meds include https://t.co/xOnH3jm6Jy
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Dr. Orrin Troum at #RWCS24 lecturing on GLP1 agonists and other diabetes therapies in rheum pts. #RWCS24 https://t.co/jzJk8xGNxz
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Sweets syndrome and manifestations #rwcs24 https://t.co/8Hev4Cmu8z
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Dr. Anisha Dua at #RWCS24 lecturing on vasculitis mimics https://t.co/Bo31icqn7S
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Catastrophic APL has high mortality.. Use of triple Rx w pulse steroids, IV heparin and plasma exchange still only has 50% survival. #RWCS24 https://t.co/ycttHcpmjL
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Congratulations to Dr. Megan Clowse - named the new chief of the Division of Rheumatology and Immunology at Duke University School of Medicine, Durham, N.C. !! @clowse https://t.co/d6iCEHlF3F
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Obesity increase risk of psoriasis
Obesity increase risk of PsA in psoriasis pts RWCS24 https://t.co/Wt9h0QLbKH
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Obesity is assoc w higher CRP.
Losing weight lowers CRP RWCS24 https://t.co/Gc6TKtmOgI
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