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Top 5 Clinical Pearls in RA Management

d Rachel Tate, DO

RheumNow Live 2024 provided a wealth of clinical insights, particularly in the realm of rheumatoid arthritis (RA) management. Here are the top five clinical pearls from the event's opening session, "Success in Rheumatoid Arthritis."

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APIPPRA Trial: Abatacept in at-risk rheumatoid arthritis patients

d Jack Cush, MD

Abatacept has been studied in seropositive clinically suspect arthralgia patients (at risk for rheumatoid arthritis) and shows the potential to delay or prevent the disease. 

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Could Weight-Loss Drug Improve Hip Replacement Outcomes?

d MedPage Today

The antidiabetic and weight-loss drug semaglutide (Ozempic, Wegovy, Rybelsus) either does or does not help patients undergoing total hip arthroplasty (THA) avoid complications and other poor outcomes, according to two retrospective studies presented here.

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RNL24

What are the Early Stages of Lupus?

d Eric Dein, MD

Incomplete lupus? Undifferentiated connective tissue disease? Pre-clinical autoimmune disease? During the lupus pod at RheumNow Live 2024, Dr. David Karp discussed the spectrum of autoimmune disease and the confusing terminology that is used with the complex world of early autoimmune disease. He cautioned against the traditional use of phrases such as incomplete lupus or undifferentiated connective tissue disease, which are heterogeneous and poorly defined.

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Sarcoid arthritis (SA) seen in 19% of sarcoid pts. Metanalsysis of 49 articles (8574 pts) found Ankles most frequent (80%) followed by knees & wrists. Monoarthritis was uncommon (1%). Acute , 0-2, I2 55%). Acute SA (oligo & poly) was linked to E nodosum. https://t.co/XPbS4vVX9o https://t.co/CqonQ1a3wW

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Dr. John Cush RheumNow ( View Tweet)
In 551 juvenile myositis pts, 36% had myositis assoc Abs (MAA); 13% had >1 MAA. MAA+ pts had more overlap dz (18 vs 6%, p<.001) & assoc w/ Raynauds (OR 2.44), ILD (OR 3.43), chronic Dz (OR 1.72), mortality (OR 3.76). # MAAs was assoc w/ mortality (OR 1.83) https://t.co/gvHIEuiG66
Dr. John Cush RheumNow ( View Tweet)
Study of 43 SSc patients w/ gangrene shows Smoking Hx ; positive-ACA, ANCA, APL Abs & high ESR were independent risk factors for digital gangrenes in SSc. Vasculitis and macrovascular disease may contribute to the progression of digital gangrene https://t.co/YmwurwymLb https://t.co/RiOIkbIEXM

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Dr. John Cush RheumNow ( View Tweet)
Transcriptome analysis (of PBMCs) looked for differential gene expression btwn 125 SJIA & 92 healthy controls identified 4 key genes (ALDH1A1, CEACAM1, YBX3 and SLC6A8) distinguishing SJIA; & may aid in diagnosis. https://t.co/M6pfajw3U3 https://t.co/VVwrYUJcBH

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Dr. John Cush RheumNow ( View Tweet)
#RWCS24 New diabetes meds include https://t.co/xOnH3jm6Jy
Dr. John Cush RheumNow ( View Tweet)
Dr. Orrin Troum at #RWCS24 lecturing on GLP1 agonists and other diabetes therapies in rheum pts. #RWCS24 https://t.co/jzJk8xGNxz
Dr. John Cush RheumNow ( View Tweet)
Sweets syndrome and manifestations #rwcs24 https://t.co/8Hev4Cmu8z
Dr. John Cush RheumNow ( View Tweet)
Dr. Anisha Dua at #RWCS24 lecturing on vasculitis mimics https://t.co/Bo31icqn7S
Dr. John Cush RheumNow ( View Tweet)
Catastrophic APL has high mortality.. Use of triple Rx w pulse steroids, IV heparin and plasma exchange still only has 50% survival. #RWCS24 https://t.co/ycttHcpmjL
Dr. John Cush RheumNow ( View Tweet)
Congratulations to Dr. Megan Clowse - named the new chief of the Division of Rheumatology and Immunology at Duke University School of Medicine, Durham, N.C. !! @clowse https://t.co/d6iCEHlF3F

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Dr. John Cush RheumNow ( View Tweet)

Obesity increase risk of psoriasis Obesity increase risk of PsA in psoriasis pts RWCS24 https://t.co/Wt9h0QLbKH
Dr. John Cush RheumNow ( View Tweet)
Obesity is assoc w higher CRP. Losing weight lowers CRP RWCS24 https://t.co/Gc6TKtmOgI
Dr. John Cush RheumNow ( View Tweet)
Higher adipose in RA linked to atherosclerosis but protects against erosions RWCS24 https://t.co/qsFMhj4LyZ
Dr. John Cush RheumNow ( View Tweet)
Dr Jon Giles at #RWCS24 shows adipose tissue produces pro inflammatory ytokines https://t.co/8NMAWIODuQ
Dr. John Cush RheumNow ( View Tweet)
Co-management of Psoriatic Disease It is a common clinical scenario to see someone with both severe psoriatic arthritis and skin psoriasis. Co-management with dermatology optimises the care of this patient group. https://t.co/8xZ9ZBpa3O https://t.co/xMYLhxA1j1

Links:

Dr. John Cush RheumNow ( View Tweet)
RWCS 2024 is Kicked off by Dr Artie Kavaugh in Maui. Watch for tweets from #RWCS24 #ValentinesDay https://t.co/iPKIfXphrx
Dr. John Cush RheumNow ( View Tweet)

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