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#ACR21 #Abstr1492 Could gut microbiome contribute to Anti-Ro+/autoimmunity in #lupus? Analyses of 125 stool samples from mother of children with neonatal lupus and/or heart block revealed its potential role in genetic-environment interaction @RheumNow https://t.co/FnJtZJSCRj https://t.co/ttRdP9NIrG
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#ACR21 Ab#1681: ATI-450- MK2 Inhibitor
⭐️Downstream MK2 mediated inflamm drive of p38.
⭐️Hope this would avoid tachyphylaxis in p38 inhibitor meds
▶️Phase2a study in 19 pts: Well-tolerated (SEs: UTI, ventricular extrasystole), good 12 week data
@Rheumnow https://t.co/6lo7zPJUpx
Links:
Eric Dein ericdeinmd ( View Tweet)
Prof. Cornelia Weyand wonderfully summarizes the mechanisms behind the premature immune #aging phenotype in #RheumatoidArthritis leading to tissue #Inflammation
🔸defect in mitoDNA repair
🔸expanded rough ER
🔸⬇ protein myristoylation
@RheumNow #ACR21 #RheumTwitter https://t.co/8cyqLscctB
sheila RHEUMarampa ( View Tweet)
Did you know?🤔Immune #aging:
🔖Begins at 20y and accelerates at 50y
🔖Species-specific
🔖The older immune system is restructured (keep that in mind when diagnosing or treating these pts)
🔖Accelerated w/ chemotx, chronic infection etc.
@RheumNow #ACR21 https://t.co/bgbN3VKMCw
sheila RHEUMarampa ( View Tweet)
#ACR21 Year in Review. Caielli et al. showed in some patients with #lupus, red blood cells retained their mitochondria (Mito+ RBCs) and their frequency correlated with disease activity and blood⬆️IFN @RheumNow https://t.co/ZixgAbOWJ0 https://t.co/hkTWE4m7Ph
Links:
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#Abstr0002 #ACR21 What drives salt in saliva in #sjogren? A study suggested Bcell cytokines mediated the epithelial Na+ Channel disruption. A case for targeting Bcell to improve oral health @RheumNow https://t.co/Bx3kBpOIFX https://t.co/YYnC6UoMJY
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
⭐️AxSpA pts with decrease in oral microbial diversity
⭐️Immune response to oral/fecal microbes altered in AxSpA pts.
⭐️HLA-B27 associated ⬆️IgA coated microbes, may contribute to development of AxSpA
Abs#0052
https://t.co/NQgm0lpYJj
#ACR21
@RheumNow
Links:
Robert B Chao, MD doctorRBC ( View Tweet)
Dr Preger report 9 novel aminoacyl tRNA synthetases in IIM patients. May these allow us to spare more patients biopsy? Abstr#0001 #ACR21 @RheumNow https://t.co/ikNXCEOeuj
Richard Conway RichardPAConway ( View Tweet)
apart from that, fibrosis is fascinating - as is the potential for a shared fibrotic pathway
#ACR21 Antifibrotics session @RheumNow https://t.co/FXbhBx9sJ1
David Liew drdavidliew ( View Tweet)
BAFF & APRIL support B cell development, diff, survival.
ALPN-303: Antagonist of both BAFF & APRIL
💠⬇️B cell fxn & Ab production,⬇️Plasma cells
💠⬇️UProt, dsDNA, renal immune complexes (mouse model)
💠Pending human studies
https://t.co/kzVpUDuNWs
#ACR21 Abst#1429 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Novel way to treat inflammatory arthritis!
A bioengineered probiotic bacterium, L. reuteri (LrS235) was found effective to reduce inflammation and clinical signs of inflammation in rats with inflammatory arthritis.
Abst # 1707 #ACR21 @rheumnow https://t.co/UC28yRlGYP
TheDaoIndex KDAO2011 ( View Tweet)
Wager question that cemented the winners: @UTMB:
⭐️This monogenic disease can mimic Behcet's & occurs d/t mutat in TNFAIP3.
➡️Haploinsufficiency A20
Congrats to the winners & all contestants, including the top 2 finalists: @MGHrheumatology & @EmoryUniversity!
#ACR21 @RheumNow https://t.co/LZqsBKiPL8
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Anti-NETs antibodies in #COVID.
1️⃣ correlate➖ w/ SpO2/FiO2 ratio (IgG r=-0.17 IgM r=-0.30
2️⃣correlate➕ w/ ⬆️D-dimer (IgG r=0.33 IgM r=0.19
3️⃣ ⬆️ in pts requiring MV
In a study of 328 pts. Probably driving complement activation!
#ACR21 #Abst1430 @RheumNow https://t.co/2MCrLueTzN
Aurelie Najm AurelieRheumo ( View Tweet)
Wonderful interview @KDAO2011 and @alhkim with great learning points on #BCell #Immunology
#ACR21 @RheumNow https://t.co/1292FNZanL
Akhil Sood MD AkhilSoodMD ( View Tweet)
#ACR21 Abs:#1429: ALPN-303: Dual BAFF/APRIL antagonist for SLE:
⭐️Encouraging immunomodulatory activity and efficacy in animal models. ⬇️ Plasma cells and Ig secretions in vitro & vivo
⭐️Well-tolerated in animals w/o adverse events
🔥Phase 1 study in healthy volunteers!
@Rheumnow
Eric Dein ericdeinmd ( View Tweet)
ACR21 Best Abstracts - Day 2
The RheumNow faculty reporters have been scouring and reporting on the best abstracts from the ACR. Here is a sampling of their choice abstract presentations reported during ACR 2020 Day 2 (#ACRbest).
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Abst#0572: In US veterans w/ RA followed for 17 yrs, several cytokines+chemokines
⭐️Associated w/ ↑ risk of incident MACE independent of typical CVD RF & RA activity
&
⭐️Predicted MACE even if in LDA/remission
WOW! We need to do better @ CVD risk strat!
#ACRBest @RheumNow https://t.co/J74rRa9EQE
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
⭐️RA pts w/ high adipokines (fat-secreted proteins) have lower rates of LDA + remission independent of b/l dz activity & BMI
⭐️↑ adipokines esp adiponectin, then more likely to need b/tsDMARD
➡️Adipokines may be prognostic biomarkers 4 refractory dz.
Abst#0789 #ACR21 @RheumNow https://t.co/AFT22TzTFp
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Opening Day Report
The opening of ACR2 Convergence was a hit for all who signed up and viewed in. The day included the presidential address by outgoing president Dr. David Karp (UT Southwestern) and a keynote talk and interview with Dr. Seema Yasmin (Stanford).
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#ACR21 Ignaki Sanz makes the case that +++ AUTOANTIBODIES are integrally involved in #COVID19 immunopathogeneisis and may rise and fall w disease states- TBD what role they play in acute disease and #LongCovid @CCalabreseDO @VirusesImmunity @CleClinicMD #COVID19AB https://t.co/9dzCSh5V7R
Leonard Calabrese LCalabreseDO ( View Tweet)