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Protips: Plasmablasts are made after B cell activation, making dsDNAAb & NMDA Ab that bind complement forming IC’s. A drug targeting plasmablast may be a better target. Belimumab may work better for short-lived B cell problems. – Dr. M Kahlenberg @rheumnow #RNL2024 https://t.co/vj6sRn4f7c
TheDaoIndex KDAO2011 ( View Tweet)
BAFF levels are high in patients lupus and allow for survival of autoreactive B cells. – Dr. M Kahlenberg on contributors to #SLE flares. #belimumab blocks BAFF but takes a long time to work, consider adding something faster active like steroids. @rheumnow #RNL2024 https://t.co/QGTcAgqjSN
TheDaoIndex KDAO2011 ( View Tweet)
T cells are important in SLE flares (but are not the only player) - Dr. M Kahlenberg @rheumnow #RNL2024 https://t.co/xFeYrKHnGi
TheDaoIndex KDAO2011 ( View Tweet)
Treatment of SLE. EULAR guidelines via @Kahlenberglab @RheumNow #RNL2024 https://t.co/a5lWfRLuh3
Richard Conway RichardPAConway ( View Tweet)
Triggers for SLE flare by @Kahlenberglab . Here in Ireland, it is so often UV light (oh its not warm enough for sunblock, its cloudy, I was only out for 20 minutes, etc). We must get our messaging better @RheumNow #RNL2024 https://t.co/0T1oJH8MqJ
Richard Conway RichardPAConway ( View Tweet)
Mimics of SLE flare by @Kahlenberglab . They are many, common, and crucial @RheumNow #RNL2024 https://t.co/P7b72T9GS6
Richard Conway RichardPAConway ( View Tweet)
Type 1 IFNs are a unique feature that impacts disease – Dr. M Kahlenberg noted innate immune cells & tissue are triggered by UV light, microorganisms, causing changes to the immune system: DC’s and B cells are more active, represses Tregs, drive skin disease. #RNL2024 @rheumnow https://t.co/fXnPIFN6VA
TheDaoIndex KDAO2011 ( View Tweet)
“Flares require a trigger!” – Dr. M Kahlenberg on #SLE flares #RNL2024 @rheumnow https://t.co/rqAnAOfJZP
TheDaoIndex KDAO2011 ( View Tweet)
Is it a lupus flare or a mimic? Fibromyalgia, stress, infection, poor sleep, hypothyroidism, vitamin deficiencies can contribute to pain and fatigue in a patient. – Dr. M Kahlenberg #RNL2024 @rheumnow https://t.co/pLuqyy8gHm
TheDaoIndex KDAO2011 ( View Tweet)
Lupus has many flavors. If we are better able to sort them, we might be more better at finding effective treatments. @rheumnow #RNL2024 @DrDavidKarp https://t.co/rklqnA8Ur6
TheDaoIndex KDAO2011 ( View Tweet)
"SLE affects women in the prime of their life, 25% of pts go to the ER, up to 50% will have lupus nephritis; it is a deadly and costly disease.” - @DrDavidKarp on why we would be focusing on identifying preclinical SLE and preventing the disease #RNL2024 @rheumnow https://t.co/SIZ5ZBwu94
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Should we define preclinical SLE as stages rather than using confusing nomenclatures like UCTD, incomplete lupus, etc? - @DrDavidKarp @rheumnow #RNL2024 https://t.co/OjRjdBzJWE
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When should you intervene? We talk about primary and secondary prevention... but what about primordial prevention that targets social determinants of health? - @drdavidkarp #RNL2024 @rheumnow https://t.co/UGAcNFLqZf
TheDaoIndex KDAO2011 ( View Tweet)
What early biomarkers are specific for SLE? How many will progress to stage 2? Who should we screen? Will patients revert to pre-stage 1? Is progression preventable? @DrDavidKarp on relevant questions we need to ask regarding preclinical stage 1 lupus. #RNL2024 @rheumnow https://t.co/bJPG68WdyE
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Can HCQ prevent SLE? Results of the MONA-LISA study is being analyzed (pts have +ANA and 1-2 SLICC criteria for SLE randomized to PCB or HCQ) - @DrDavidKarp @rheumnow #RNL2024 https://t.co/9yoFXS7wMe
TheDaoIndex KDAO2011 ( View Tweet)
#RNL2024 @RheumNow
@DrDavidKarp
Incomplete lupus is heterogeneous term
"Stage 2" pre-classification stage as ILE/UCTD
Stage 1: non-specific antibodies, dysregulation
2: incomplete features
3: classified, multi-system disease
4: irreversible tissue damage https://t.co/CuLUzSZ24E
Links:
Eric Dein ericdeinmd ( View Tweet)
@reumacia @RheumNow You are absolutely right. The point was not generally used for psoriasis ( not PsA). I was surprised my self 🤕.
Here is the slide again by Dr. Armstrong , great talk by the way. Let me know if you want the handout. https://t.co/C11Gkn2jho
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Appreciative inquiry in rheumatology and how to enhance and improve our clinical notes to frame our encounter in a positive manner.
@BharatKumarMD
#RNL2024
@RheumNow https://t.co/iTXwjUb6tg
Links:
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Some takeways from JAK inhibitors in dermatology talk by Bruce Strober.
Great talk.
#RNL2024
@RheumNow https://t.co/fuRsSnnsha
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Alopecia aerate and JAK
Bruce Strober
#RNL2024
@RheumNow https://t.co/lGig1Vpf5x
Links:
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)