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Dafna,gladman

Honoring Dr. Dafna Gladman

d Jack Cush, MD

In December 2024, the Governor General appointed Dr. Dafna Gladman an officer to the Order of Canada, which includes some of Canada's most notable Clinicians and Scientists. Created in 1967, the Order of Canada is one of Canada's highest civilian honours. It recognizes individuals whose achievements and service have had an impact on communities across Canada and beyond.

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DMARDs,biologics,RA

Getting to Remission - Without Biologics

d Jack Cush, MD

Analysis of data from two early rheumatoid arthritis (ERA) cohorts shows remission in RA is primarily seen in those who do not require biologic DMARDs (bDMARDs), while those needing bDMARDs are less apt to achieve remission.

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Gout pills injection

Do Rheumatologists Follow 2020 ACR Guidelines on Gout?

d Jack Cush, MD

Schlessinger and colleagues report that US Rheumatologists generally adhere to and agree with the 2020 American College of Rheumatology (ACR) Guideline for the Management of Gout, although knowledge gaps and practice variance exists.

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Functional Precision Medicine in Rheumatoid Arthritis

d Jack Cush, MD

Novels research from the Medical University of Vienna demonstrates the plausible utility of functional precision medicine using immunophenotyping of blood cells with rheumatoid arthritis, to help guide treatment selection.

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Cardiovascular Risk in Cutaneous Lupus Erythematosus

d Jack Cush, MD

A retrospective study of cutaneous lupus erythematosus (CLE) patients finds an increased risk of atherosclerotic cardiovascular disease (ASCVD) on par with systemic lupus patients.

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RA higher risk of Celiac Dz -- Rheumatic Dz administrative data review (2004–2013)compared 70,061 #RA w/ 276,895 controls, median F/U 9 yrs. (IQR 9–9). Celiac Prevalence higher in RA (171/70,061 = 0.24% vs 398/276895 = 0.14%; p < 0.001), more so in females w/ RA… https://t.co/SayZYvkZpV https://t.co/fcuyJ5sFk0
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Korean population-based study shows that from 2010 to 2023 prevalence of ank Spondylitis (AS) increased 27 per 100,000 (2010) to 82 per 100,000 (2023). Also increasing were # of pts >50 yrs (20-33%), #females (18-24%), Comorbidities, TNFi use (30-43%), while csDMARDs declined.… https://t.co/9NjU1IugaF https://t.co/kTCtIj2BjD
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A substantial # of pts with inflammatory arthritis (IA) are not receiving adequate treatment for depression and anxiety(same as those IA-free controls). Canadian study of 6,951 w/ IA & depression, on 50% recv treatment & 20% psych. Rx for depression. Similar for 3,701 w/ IA &… https://t.co/CfpwEtLH3c

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Systematic review of 14 studies using administrative/med. records data on >130 million people & 1 million dementia cases, finds the risk of Alzheimers/Dementia reduced w/ Antimicrobials, vaccines & NSAID antiinflammatories (but incr w/ DM drugs, vitamins, antipsychotics)… https://t.co/p79s5Pw4k2 https://t.co/9DO1WO2NuG
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Metanalysis of 11 studies shows that curcumin (tumeric) can reduce pain, muscle damage and inflammation in athletes following vigorous physical exercise. "pre- and post-exercise curcumin consumption.. assoc w/ better outcomes in muscle recovery, pain & antioxidant capacity"… https://t.co/J07UId683Y

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Congratulations to Jennifer Anolik, MD, PhD, being named chief of the Allergy, Immunology & Rheumatology at the Univ. of Rochester Medical Center; where she is also Assoc Chair of research & professor of Medicine, Pathology, Microbiology and Immunology, and director of the… https://t.co/jvRiZZ6u1q https://t.co/N2nFp8w6Yx
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Head-to-Head Clinical Trials https://t.co/kLwVKRcnna https://t.co/XDhk9VAIin

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Lung Involvement in Still's Disease A multicentre registry observational study assessed lung involvement in a cohort of Still’s disease patients, affirming pleuritis as most common and that parenchymal lung inflammatory disease is very uncommon in both children and adults.… https://t.co/bUvg4xQrsr https://t.co/fz7wiNU0Xx
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“Injustice anywhere is a threat to justice everywhere.” - Martin Luther King https://t.co/y3UDZP8uTN
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ACR: Congress Fails to Reform PBMs, Mitigate Medicare Cuts Save The ACR praised the limited extension of Medicare telehealth coverage but criticized Congress for not passing measures to increase transparency in PBM practices, address insurer issues, or prevent upcoming Medicare… https://t.co/pJ5f6LvELe https://t.co/jT3UJAx5It
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Population survey study of 933 gout pts (mean 58 yrs, 76% male,80% white) found total gout flare burden = 6.6 gout flares per year. Nearly 72% of gout flares were not reported, pretreated or prevented. Those less likely to report flares were young, less school, lower CCI, less… https://t.co/Z7KWk1YEFH https://t.co/0jDGNMOKjj
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🎉 RheumNow Live 2025 is just about 2 weeks away! 🌟 Don't miss expert talks, interactive panels, networking, and the Karaoke Gong Show! Early registration extended—secure your spot now! 🗓️ Virtual & in-person options available. https://t.co/EPZJMOGgNk https://t.co/cMoOTlWKYu

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Fallen Angels (1.17.2025) Dr. Jack Cush reviews the news and journal reports from the past week on https://t.co/V10S4oVFsv; and pays homage to colleagues who passed away in 2024. https://t.co/1DvtGbUHEk https://t.co/EnZ8D6xzgk

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post hoc analysis of 4 registration trials of pegloticase, show rates of MACE and Thromboembolic Events were Infrequent (<1.5%; 35.4 events/1000 PY), similar to general gout population (31.7 events/1000 person-years) https://t.co/z1QAELA3ua https://t.co/polmf9hI6I

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We must learn to live together as brothers or perish together as fools. Martin Luther King Jr. (1929 - 1968) https://t.co/3mWHhPY5rH
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