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Marc Hochberg lecture at #ACR21 - Bisphosphonates limited and inconclusive data in radiographic progression of OA, some ⬇️ in bone marrow lesions! @RheumNow https://t.co/ciMUINBLwm
Bella Mehta bella_mehta ( View Tweet)
Dr. Marc Hochberg delivering the Oscar Gluck Memorial lecture - His talk titled "The Role of Bone in OA". He begins with this statement.... "DJD... Should never be used" - the rest of the lecture explains why. #ACR21 https://t.co/lYGsFu4Wpr https://t.co/IWP5J73mFO

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Dr. John Cush RheumNow ( View Tweet)
MCP, wrist, elbow, shoulder and ankle: Not common sites for #osteoarthritis so consider a metabolic disease like CPPD🧐 @RheumNow #ACR21 #RheumTwitter #MedTwitter https://t.co/utId4ljsZK
sheila RHEUMarampa ( View Tweet)
Phase 3 observational extension study of Lorecivivint, intra-articular CLK/DYRK inhibitor that modulates Wnt and inflammatory pathways. Safety and tolerability. Efficacy at 6 and 12 month, but at 18month it disappeared @RheumNow #ACR21 abst#0729 https://t.co/9ycbVGKkmy
Bella Mehta bella_mehta ( View Tweet)
Single Intraarticular Canakinumab in Knee OA - 18-week randomized, double-blind, double-dummy Placebo and naproxen-controlled - effect no different than Placebo. Some efficacy in subgroup with high hsCRP. Need for subtypes in OA @rheumnow #ACR21 #abst0728 https://t.co/YlKTMf56wF
Bella Mehta bella_mehta ( View Tweet)
Rx of knee OA. A step in the right direction? Many knee #OA studies show that exercise can help pain and maybe much more - strengthening, alignment, tone, maybe weight loss. Here is a trial - STEP-KOA to support it. #YearInReview #ACR21 @RheumNow https://t.co/rTZUeZuT1c

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Janet Pope Janetbirdope ( View Tweet)

answer: CPPD. 👉CPPD can look like OA but can be more aggressive. 👉Look for chondrocalcinosis at the triangular ligament, pubic symphyis, superiolateral femoral head 👉A common cause of scapholunate widening 👉CPPD loves the patellofemoral joint (knee joint may be spared) https://t.co/wgYjJwYvb0
TheDaoIndex KDAO2011 ( View Tweet)
Wanted to highlight our work @HSpecialSurgery presented at #ACR21 using unsupervised clustering of multimodal data - histology and ultrasound to identify phenotypes such as moderately inflammatory subtype in #osteoarthritis @RheumNow #abst0212 some features highlighted in fig https://t.co/HRzhMXctB9
Bella Mehta bella_mehta ( View Tweet)
Pearls on Rheum imaging: 👉CPPD is not erosive 👉SC joint in OA is common (hard to image) 👉AC joint is 1st place OA affects shoulders (not GH) 👉Neuropathic OA progress rapidly, look at the TMTs 👉Get more views if you aren't seeing what you need #ACR21 Radiology Bootcamp

TheDaoIndex KDAO2011 ( View Tweet)

STEP-KOA trial: a promising intervention for knee #osteoarthritis?🤔 @RheumNow #ACR21 #YearinReview https://t.co/6Vkx0WR0tx
sheila RHEUMarampa ( View Tweet)
#ACR21 Year in Review: Stepped Exercise program for knee OA - decrease in pain and increase in function, without objective measures showing improvement. Time to prescribe exercise! @Rheumnow https://t.co/LrNZ3pBO9i
Eric Dein ericdeinmd ( View Tweet)
How to improve clinical care for knee OA? stepped exercise program helps WOMAC self reported pain outcomes in Knee OA Important RCT #ACR21 year in review by @karen_kc123 @RheumNow @AnnalsofIM here is a paper https://t.co/RGIjBL9TuZ

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Bella Mehta bella_mehta ( View Tweet)

Large GWAS Study Reveals Genetic Basis for Osteoarthritis Phenotypes https://t.co/6pR5FInBBA https://t.co/B95HHzLDzk

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Dr. John Cush RheumNow ( View Tweet)
DNA,genotyping,gene,sequencing

Large GWAS Study Reveals Genetic Basis for Osteoarthritis Phenotypes

d Jack Cush, MD

Cell has published the results of a multinational, GWAS meta-analyses of 826,690 individuals that included 177,517 osteoarthritis patients, finding 52 previously unknown osteoarthritis (OA) genetic risk variants and linking OA genetic risks with joint distribution and pain

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RheumNow Podcast square

RheumNow Podcast – Like Father, Like Daughter (10.29.2021)

d Jack Cush, MD

Bad things happen when our patients go into the ICU and it's not always due to the disease. Good things happen when we rise from sitting. And guess what? Rheumatologists are setting cardiology straight about hydroxychloroquine and chloroquine. This, and a special recognition of parent-child rheumatologists, along with the news and articles from this week on RheumNow.

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ankle,xray

Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis

d Jack Cush, MD

A controlled trial of intra-articular platelet-rich plasma (PRP) injections into the ankle of osteoarthritis (OA) patients failed to improve ankle symptoms and function when compared to placebo injections - yet another trial showing that intraarticular injections are seldom beneficial.

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Hip

Pfizer/Lilly Pull Tanezumab Development

d Jack Cush, MD

Today, Lilly and Pfizer announced their global clinical development of the NGF inhibitor, tanezumab, has been discontinued due to recent negative opinions from the EMA and FDA advisory committee.

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Metanalysis of NSAIDs & opioids in Knee/Hip #OA - 192 RCTs (102829 pts). AE dropouts & adverse events were ZERO w/ topical NSAIDs; highest w/ opioids (83% & 90%). Pronounced Rx benefit more likely w/ oral & topical NSAIDs (99 & 93% probability) https://t.co/376uAzMcpH

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Dr. John Cush RheumNow ( View Tweet)

The CDC estimates of the national prevalence of arthritis and arthritis-attributable activity limitations (AAAL) show a continued increase in absolute number: 58.5 million US adults have arthritis, 25.7 million of whom have AAAL. Read more on #RheumNow https://t.co/9RNIduVCZh https://t.co/fzxWMbcEfU

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: An erosive hand osteoarthritis (EOA) study from the Osteoarthritis Initiative shows that EOA is more common in older women and is strongly linked to further progressive, articular structural damage. https://t.co/XOVKNj423l #RheumNow https://t.co/CYxW6mJpCH

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Dr. John Cush RheumNow ( View Tweet)

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