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Early DMARD Therapy Averts Cardiovascular Risk in RA
A Finnish early RA register studied 14,878 incident RA patients from 2000-2008 and identified 1157 deaths. Patients receiving DMARDs and MTX had lower mortality rates. The standardized mortality ratio for the entire cohort was reduced (0.57, 95% CI 0.52 to 0.62).
Read ArticleTocilizumab in Pregnancy
Tocilizumab is currently listed as a Category "C" pregnancy risk based on limited pre-clinical (animal) data that was negative.
Read ArticleCancer Risk Lower with TNF inhibitors in Rheumatoid Arthritis
Since the introduction of TNF inhibitors nearly 20 years ago, concerns over a potential associated cancer risk have abounded. The recent ACR RA treatment guidelines have addressed this recently, stating that patients with any solid tumor cancer or risk thereof should be treated as if they ha
Read ArticleBiologics and Fatigue in Rheumatoid Arthritis
Researchers from Bristol, UK have published a Cochrane review studying the effects of biologic therapies on fatigue.
Read ArticleRheumNow Week in Review – 24 June 2016
Dr. Cush reviews highlights published this week at RheumNow.com.
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Hypogonadism Ups the Risk of Autoimmunity
In a variety of models, testosterone has been shown to be immunosuppressive and deficiency of testosterone has been linked with autoimmune disease and increases in C-reactive protein (CRP), tumor necrosis factor, and interleukin-6 (IL-6).
Read ArticlePredictors of Progression in Early Inflammatory Polyarthritis
A substantial, but unclear, percentage of patients presenting with new onset inflammatory polyarthritis (IP) will spontaneously remit, while others may persist and develop rheumatoid arthritis (RA).
Read ArticleNew EULAR Guidelines on Behçet's
At the EULAR 2016 meeting, new EULAR recommendations for the management of Behçet's disease (BD) were presented.
Read ArticleEULAR 2016 Drug Safety Report
The EULAR Annual European Congress of Rheumatology meeting was held in London from June 8-11, 2016 and was well attended by thousands. This year’s meeting had over 2,000 poster displays, and the EULAR 2016 Congress presented new recommendations on the management of rheumatoid arthritis, spondyloarthritis, and fibromyalgia.
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Steroid Use in Early Rheumatoid Arthritis Associated with Fractures
The impact of systemic glucocorticoid exposure on fracture risk among new-onset rheumatoid arthritis (RA) was studied using administrative claims data detailing the treatments and outcomes of 42,127 newly diagnosed RA patients (between 2005-2012).
Read ArticleEuropean Registries Show No Melanoma Risk with Biologics
The combined analysis of 130,315 rheumatoid arthritis patients from 11 European registries did not reveal an association between invasive (malignant) melanoma and the use of biologic therapies.
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Long-Acting Opioids Associated with Higher Mortality Risk
Prescription of long-acting opioids for chronic noncancer pain was associated with an increased risk of all-cause mortality, including deaths from causes other than overdose, compared with anticonvulsants or cyclic antidepressants, according to a study appearing in the June 14 issue of JAMA.
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Parathyroidectomy Improves and Bisphosphonates Worsen Fracture Risk in Primary Hyperparathyroidism
A retrospective observational study of over 6000 patients with primary hyperparathyroidism (PHPT), followed in the Kaiser-Permanente system, has shown a greater need for parathyroidectomy than was previously thought.
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U-ACT-Early and the Benefits of Tocilizumab
Lancet has published the results of the U-ACT-early study assessing the efficacy of monotherapy versus combination therapy using an interleukin-6 receptor-blocking monoclonal antibody, tocilizumab, in patients with rheumatoid arthritis.
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Pre-Clinical Use of Rituximab Forestalls Rheumatoid Onset
The results of the PRAIRI study were presented today at EULAR 2016 in London. These early findings suggest that individuals "at-risk" to develop rheumatoid arthritis (RA) may benefit from a short course of intravenously rituximab therapy.
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Hospitalizations Decline for Rheumatoid Arthritis, But Increase in Gout
JAMA has reported the results of an 18-year National Inpatient Sample, a database of US non-federal hospitalizations.
Read ArticleEight Deaths Linked to Methotrexate in Australia
Methotrexate , a cornerstone drug used to treat rheumatoid arthritis, has led to 90 hospitalizations and 7 deaths according to a recent report from the Medical Journal of Australia.
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April-May 2016 Top Social Media News
In April and May 2016, RheumNow sent 82 tweets regarding news, research and teaching points that strongly impacted the rheumatology community and resulted in a reach of 203,500 impressions, with 136 mentions, and over 6378 visits to RheumNow.com. Here are the top tweets from April and May.
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RheumNow Week in Review - 3 June 2016
This week's highlights from RheumNow.com include:
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