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HCQ improves complements
A#2327 #ACR23 @RheumNow
Petri @jhrheumatology @andreafava
Pts w/ low complement & low HCQ levels
In pts who increased HCQ WB level >50 ng/mL, incr in mean C3 (p=0.02) v HCQ that did not incr
More nml C4 levels (p=.003) and incr mean C4 (p=.004) on HCQ https://t.co/J7PIuaRTO8
Eric Dein ( View Tweet)
HCQ Discontinuation
A#2343 #ACR23 @RheumNow
42 pts d/c HCQ
19% flared in past yr before d/c
D/c reasons: retina tox 57%, self-dc 17%, other eye issue 12%
26% flare in yr after d/c - strongest ass for flare: mean C3, dsDNA+ at index visit https://t.co/d4TqneS46u
Eric Dein ( View Tweet)
Another day, another bimekizumab (IL17i) study
Across 2 trials, improved PsA specific QOL ("PsAID") metrics
Nice to see focus on PROs & I always love a good spidergram
@RheumNow #ACR23 Absr2249 https://t.co/dsLXstPzt2
Mike Putman EBRheum ( View Tweet)
The patients’ voice matters! Watch my interview with @LAlupusLady regarding how she manages #Lupus and her perspective about the disease @rheumnow #ACR23 @uptoTate https://t.co/P9KPJQEkRv
TheDaoIndex KDAO2011 ( View Tweet)
All of us need to remind each other to take care of yourself!
Some tips from Dr. Whitney Marvin
- exercise, date night, talking to a friend
- take breaks, mindfulness
- eating away from computer (as I type this on my desk, next to my lunch)
@RheumNow #ACR23 https://t.co/UmmDqXRECN
Robert B Chao, MD ( View Tweet)
Will postpartum BME ⏩axSpA-like structural lesions?
Study by Varkas et al show there was no significant dev't of axSpA-like lesions on MRI in postpartum women 5 yrs after delivery.
Postpartum BME likely sec to transient mech stress-induced SI BME
#ACR23 ABST1892 @RheumNow https://t.co/KJ3DngmkbI
sheila ( View Tweet)
Always refreshing to hear from another specialist's point of view
Cardiologist @Bweber04 on CVD and rheumatologic diseases
Increased risk of death, MI and HF exacerbation in our pt population
Increased all cause mortality
@RheumNow #ACR23 https://t.co/yOkPOmxU4N
Robert B Chao, MD ( View Tweet)
@Bweber04 on recurrent pericarditis especially some seen in our lupus population
IL-1 inhibition with Rilonacept really redefining treatment success and altering the typical treatment algorithm
@RheumNow #ACR23 https://t.co/Ey1DN8eSXT
Robert B Chao, MD ( View Tweet)
Later today at #ACR23 at 4pm
See Ab#2545 on IV secukinumab for AxSpA
Read about it now on @RheumNow:
https://t.co/s9IinpVxgR
Eric Dein ( View Tweet)
RheumNow’s expanded coverage of #ACR23 annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty.
Dr. John Cush RheumNow ( View Tweet)
Watch: Ultrasound for PsA Stratification: Are We There Yet?
Dr. Aurelie Najm reports live from #ACR23
https://t.co/TnDVbKXcd4 https://t.co/RTbjL2wbUj
Dr. John Cush RheumNow ( View Tweet)
Interesting counterpoint to a tweet from a few days ago re:black box warning for JAKs
No change in utilization rates post black box... maybe people had already baked this into the cake by then?
@RheumNow #ACR23 Abstr 2142 https://t.co/K9cWbRSWV6
Mike Putman EBRheum ( View Tweet)
Amazing & thoughtful poster re:protocol violates in TICOSPA trial
51.2% of pts violated T2T protocol at least once... but did not impact primary outcome
Good baseline for future "strategy" style pragmatic trials
@RheumNow #ACR23 #ACRBest Abstr2201 https://t.co/FhctgFNdNP
Mike Putman EBRheum ( View Tweet)
#ACR23 Late-Breaking Abstr#L09 In a crowded market, you’ve got to stand out. Phase 2 RCT of LNK01001, a highly selective JAK1-i in China: improvement in ACR 20,50,70 vs PBO at WK12. Those in PBO who didn’t meet ACR20 improved after receiving Tx. Very low infections @RheumNow https://t.co/ZbJFNHOtFT
Md Yuzaiful Md Yusof ( View Tweet)
A#L09 #ACR23 @RheumNow
New JAK! LNK01001
Chinese pts with mod-severe RA, csDMARD failures
12mg/24mg/PBO: W12: ACR20 60/73/31%, ACR50 40/42/9, ACR70 12/21/2%
Stat signif diff reached at wk 1 for ACR20!
Improved DAS28, HAQ-DI
Wk24 ext: 91% remain in ACR 20
AEs: HLD noted https://t.co/RXOMzxGOTy
Eric Dein ( View Tweet)
CV Events in AS by Rx
A#L11 @RheumNow #ACR23
43K pts from Korean data
Rates of incident MI or CV:
18.7 per 10,000 py in non-bDMARD pt
8.9 in TNF
12.9 in IL-17
TNFi reduced risk of CVD HR 0.7, not signif for IL-17
Supports idea of TNFi giving a cardioprotective effect?
#ACRBest https://t.co/SvVVDSU23z
Eric Dein ( View Tweet)
ARTIC REWIND: To taper or not?
A#L07 #ACR23 @RheumNow
RA pts taper TNFi in stable remission
No taper group: 85% flare free in 3 yrs
Taper grp: only 25%
Lower Boolean 2.0 Remission rates
Don't taper off a good thing! https://t.co/KnJrEfVFkV
Eric Dein ( View Tweet)
Lessons for #CVD in #inflammatory #rheumatic #diseases #ACR23 @RheumNow @ACRheum #ACRbest
-Negative #coronary #calcification doesn’t r/o presence of #microvascular #dysfunction
- work w #cardiologist for@proper@imaging for #Dx
-for #CAD or #pericarditis #Colchicine is GOOD https://t.co/dMO1FpoA2a
Janet Pope ( View Tweet)
Excellent session: Navigating CV risk for #inflammatory #arthritis - view from #cardiology #ACR23 14T118 @RheumNow @ACRheum https://t.co/WKhh0TonE8
Janet Pope ( View Tweet)
#ACR23 Late-Breaking Abstr#L14 Which team are you on? IL5-i or IL5-receptor-i #EGPA. Phase 3 H2H RCT showed similar efficacy btw Mepolizumab and Benralizumab, with more pts fully tapering off GC at WK52 favouring BENRA. Rapid reduction in Eosinophils too @RheumNow #ACRBest https://t.co/cXhSS80mA2
Md Yuzaiful Md Yusof ( View Tweet)