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Dr. Jack Cush reviews the news, journal reports, FDA actions, new side effects and changing prevalence of Gout.
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Analysis of rheumatoid arthritis (RA) data from the British Society for Rheumatology Biologics Register shows that, even after failing three or more biologic or targeted synthetic DMARDs (b/tsDMARDs), patients may continue to benefit from repeated trials of unused b/tsDMARDs.
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Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.
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JAMA has published a meta-analysis of 15 studies of hospitalized patients with COVID-19 treated with tocilizumab and corticosteroids, showing that a clinically meaningful mortality benefit from tocilizumab (and steroids) was best seen in those not requiring invasive mechanical ventilation (IMV).
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A Task Force from the ACR has provided an updated (version 3) guidance for the diagnosis and management of Multisystem Inflammatory Syndrome in Children (MIS-C), a COVID related condition characterized by fever, inflammation, and multiorgan dysfunction.
Dr. John Cush
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Ontario population study shows that musculoskeletal disorders account for 12.3% of all adult emergency dept. visits and 28.5% outpatient physician visits https://t.co/Sq9n7RkIYK https://t.co/lKtQqR5Ja3
Dr. John Cush
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Differential diagnosis of dysphagia - when due to autoimmune dz is called Autoimmune neurogenic dysphagia - causes include inflammatory myopathies,inclusion body myositis, myasthenia gravis, Guillain–Barre, MS, NMO, paraneoplastic neuropathies https://t.co/oA0cPVJ5pJ https://t.co/58MyQwmxhL
Dr. John Cush
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Making You the Expert of You! (Smart Rules for Patients)
You’ve scheduled an appointment with your medical provider - how do you make the most of it?
https://t.co/62mTqk4ksL https://t.co/gr7Hvt7EI3
Dr. John Cush
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Retrospective study of 71 adult-onset Still’s disease pts Rx 1st w/ High-dose glucocorticoids shows 41% failed to respond (poor outcome) by week4 w/ WBC as best predictor. If WBC < 13K 60% responded; if ≥13K only 23.5% https://t.co/tMNDgoqP14 https://t.co/xJrIEUU6iK
Dr. John Cush
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Biologics for JIA? Not So Fast, Say Insurers
It's not a simple matter to prescribe tumor necrosis factor (TNF) inhibitors for patients with juvenile idiopathic arthritis (JIA), at least those with insurance, a single-center study found.
https://t.co/w4A5sgv3fU https://t.co/coVh3zui2z
Dr. John Cush
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COVID-19 Vaccination Uptake and Perceptions in Rheumatic Patients
Putman et al has reported vaccine survey results from the C19-GRA in Lancet Rheumatology showing the uptake and vaccine hesitancy among people with rheumatic diseases (RMD).
https://t.co/sqsOHGThzV https://t.co/zeZrlDeQ9Z
Dr. John Cush
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Italian retrospective of Canakinumab in 80 kids w/ Systemic JIA - 12 moved from anakinra to CAN w/ iinactive dz/CID. 58 pts w/ active SoJIA started CAN - CID in 57% at 6mos, 64% 12 mos; MAS 3/100PY; Nonresp assoc w/ MAS, #Jts, Dz duration https://t.co/2YmkukU7Z2
Dr. Rachel Tate
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52% of pediatric rheumatology patients do not make initial appointments or follow ups with adult rheumatology after 2 years of transfer of care! Dr. @hausmannMD #RNL2022 @RheumNow https://t.co/3lVxH1yqud
Dr. John Cush
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Single center study of individualized anakinra use in 47 autoinflammatory pts (32kids; 43% MAS; 40% systemic JIA). Off-label use in 38%, higher doses in 21 kids (5-29mg/kg); & 5 given IV anakinra; such doses were well tolerated without major AE. https://t.co/wQgw3YAPKX https://t.co/zL3HfdX4Ns
Dr. John Cush
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New Download Available!
Autoimmune Disease in the USA
https://t.co/KvsgBUY7mL https://t.co/PSTF7ma6G6
Dr. John Cush
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Korean study of 53 424 kids with Kawasaki disease (KD) showed that outbreaks of rhinovirus, respiratory syncytial virus and varicella were significantly correlated with KD at 1 to 3 months before KD outbreaks https://t.co/U8FXao1TWn
Dr. John Cush
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ICYMI: Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/P4SzIrWzYJ https://t.co/wnf3vnG4xc
Dr. John Cush
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When to suspect an interferonopathy (when suspected you should offer an autoinflammatory panel from https://t.co/F9bat3YS1d) #RWCS2022 @RWCSmtg Dr. Susan Shenoi https://t.co/qUts9X8gwJ
Dr. John Cush
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Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/cX00RUOgAq
Dr. John Cush
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New 2021 JIA guidelines w 55 recommendations, 36 conditional and 19 strong. #RWCS2022 @RWCSmtg Dr Susan Shenoi https://t.co/CMETQeOdch
