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RheumNow Podcast – Pounds of Prevention (3.5.2021)

Jack Cush, MD

Dr. Jack Cush reviews and discusses nearly a dozen news reports and journal articles from the past week on RheumNow.com.

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Weight Loss to Avert Risk of Gout

Jack Cush, MD

Analysis of the NHANES population survey data shows weight gain during adulthood increases the risk of gout and that maintaining normal weight could reduce the overall gout risk by nearly 33%.

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Combo Therapy Boosts Response in Uncontrolled Gout

MedPage Today

The addition of an immunomodulating agent to pegloticase (Krystexxa) among patients with uncontrolled gout significantly improved response rates, a systematic literature review found.

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ANAGO Study - Anakinra for Gout Flare

MedPage Today

The interleukin (IL)-1 receptor antagonist anakinra (Kineret) was not superior to triamcinolone for relieving gout flares, but had similar effects for pain reduction as the glucocorticoid, a randomized phase II study found.

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MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout

Jack Cush, MD

Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout.

This exploratory, open-label clinical trial screened 17 patients and treated 14 patients (all men, 49.3 ± 8.7 years) with IV pegloticase with MTX (15 mg/week) and folic acid (1 mg/day) 4 weeks prior to and throughout pegloticase treatment.

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RheumNow Podcast – Rheumatology Burnout (1.29.2021)

Jack Cush, MD

Dr. Jack Cush reviews this past week's journal articles and news features on RheumNow.com. Colchicine, vaccine rollout, risk of RA in endometriosis patients, tREACH trial, lupus nephritis news, rheumatology burnout and more.

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News Feature: Weight Loss to Avert Risk of Gout https://t.co/wzf69PvSJc https://t.co/Dph4OAC2Ar

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Dr. John Cush RheumNow ( View Tweet)
Comparison of MSU crystal ID, DECT scanning and US to Dx gout - study of 147 pts. Compared to the gold standard (MSU ID), Feet/ankles (87% sensitivity; 100% specificity) or knees DECT (91% & 87%) alone had best Dx accuracy. US was inferior to DECT. https://t.co/h8ctkfeadZ

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Dr. John Cush RheumNow ( View Tweet)

News Feature: Combo Therapy Boosts Response in Uncontrolled Gout https://t.co/K6tmYWqDCg https://t.co/Li9fcLnP4f

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Dr. John Cush RheumNow ( View Tweet)
We are three weeks out from RheumNow Live. Are you planning on attending? https://t.co/vJlU0Z3Q3x

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Dr. John Cush RheumNow ( View Tweet)

News Feature: ANAGO Study - Anakinra for Gout Flare https://t.co/btP7ivMuPO https://t.co/HHsUKsjjuI

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Dr. John Cush RheumNow ( View Tweet)
SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu

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Dr. John Cush RheumNow ( View Tweet)
MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout. https://t.co/DRkIMOAhs4 https://t.co/2dft1QjC6E

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Dr. John Cush RheumNow ( View Tweet)
QD Clinic Podcast from Last week. iTunes https://t.co/FHJv01AAbC or SoundCloud https://t.co/dfSTkSbY2d QD Clinics (123-127; Feb 5) QD127 - Chronic Monarthritis QD126 - Fever by the Numbers QD125 - "What Were You Thinking" QD124 - No Win Consults QD123 - When RA Meets UC https://t.co/ReOFOVooje

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Dr. John Cush RheumNow ( View Tweet)
UK Biobank examined the association between comorbidities & uric acid (SUA). Comorbidities assoc w/ increasing SUA. For each 1 mg increase in SUA, there is a 1-3 fold incr risk of HTN, IHD, CCF, ^HL, CKD https://t.co/ZEPAPRq62k

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Dr. John Cush RheumNow ( View Tweet)

Consults in Cars--have telehealth consults gone too far? https://t.co/INbKZ3xxty https://t.co/X2RwktCd2U

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Dr. John Cush RheumNow ( View Tweet)
Our Top January Tweet: Urate Lowering Therapy During Acute Gout Acute gout has its well-defined protocols, and most state that urate lowering therapy should be continued; but does ULT affect outcomes in an acute gout attack? https://t.co/aDHpU1qrlu https://t.co/6xDwyVjuyC

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Dr. John Cush RheumNow ( View Tweet)
QD Clinic Podcast for the week of Jan 29 - Pearls from Practice This wk: Arthritis &Crohn's Rhabdo or Not Dadgummit, Where's Waldos COVID Vaccine? "I Don't Know" A Tale of Two Gouts https://t.co/7ndYSOgh5R or listen on iTunes https://t.co/FHJv01AAbC https://t.co/780P7Bdw8F

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Dr. John Cush RheumNow ( View Tweet)

Colchicine suppresses MSU & CA pyrophosphate crystal activation of Nod-Like Receptor Protein 3 (NLRP3) inflammasome, thereby suppressing caspase-1 activation and the subsequent release of IL-1β and IL-18. Great review by Pillinger et al https://t.co/n7MHtSviT5

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Dr. John Cush RheumNow ( View Tweet)

Urate Lowering Therapy During Acute Gout Acute gout has its well-defined protocols, and most state that urate lowering therapy (ULT) should be continued; but does ULT affect outcomes in an acute gout attack? https://t.co/aDHpU1I2d2 https://t.co/QihJNhMW8L

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Dr. John Cush RheumNow ( View Tweet)
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