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The SELECT-GCA study, looking at upadacitinib in GCA, anchored the ACR 2024 opening plenary for a reason - it is highly notable and badly needed.
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Lupus nephritis is one of the most silent and severe manifestations of SLE. When not captured early, patients are at high risk of progressing to end-stage renal disease, which would require dialysis or transplantation. Renal biopsy remains the gold standard for diagnosis and disease classification. However, the procedure is invasive and very painful. Non-invasive measures are critical for early detection and continuous monitoring.
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When the ACR Convergence 2024 abstract site went live, the first query I typed into the search bar was, “CAR-T.” I consider myself a CAR-T skeptic and would be surprised if the magical results from this NEJM case series replicate at scale, but it seems likely that CAR-T will revolutionize the care for (some) patients with rheumatic diseases. What new data will be presented at ACR?
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Are emulation ‘trials’ helpful, despite the biases that occur with observational data, or do they truly mimic the results of randomized controlled trials (RCTs)?
Adela Castro
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The 3-4-5 rule for positive MRI in axSpA remains.
The MRI lesion cut-offs demonstrated high performance across different features of axSpA (PsO, AAU,IBD).
Deep fat and deep sclerosis high specificity for axSpA.
#Abst0821 #ACR24 @RheumNow https://t.co/4JM5MHrB8z
Eric Dein
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Starting soon:
Room 152A
@ACRheumDC @cdowneymd @BelindaBirnbaum
What does the election and current political changes mean for rheumatology?
How does ACR play a role in supporting you? What are the easy steps you can do?
#ACR24 @RheumNow https://t.co/jTtk80RdqI
sheila
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Thrilled to have my abstract accepted for poster presentation at #ACR24 with @rheumarhyme
Drop by abs1314 to know more 🤓
#HPEd #educator #telerheumatology
@Rheumnow https://t.co/j2rZLGm7lA
Antoni Chan MD (Prof)
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Managing DMARDs in pregnancy. Curbside consults by Lisa Sammaritano @RheumNow #ACR24 https://t.co/FQrLNz4yCz
Caoilfhionn Connolly
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🫁RP-ILD a/w high morbidity and mortality
How to Predict RP-ILD Development?
➡️AutoAb: anti-MDA5, anti-ARS, anti-Ro52
➡️Biomarkers: CRP, LD, Ferritin, KL-6
➡️CT: Lower consolidation/GGO
#ACR24 @RheumNow https://t.co/OIrHfVTZcM
Dr. John Cush
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RheumNow’s expanded coverage of the #ACR24 annual meeting is sponsored in part by Novartis. All content is chosen by RheumNow & its faculty.
David Liew
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In the @ACRheum MSK Ultrasound Guidance:
In difficult-to-treat RA, MSUS can distinguish symptoms of active synovitis from other sources of pain.
(consensus: mod)
CURRENTLY do you often use ultrasound when RA gets difficult to treat, and synovitis isn't obvious? #ACR24 @RheumNow
Mike Putman
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Phase 2 DBRCT of daxdilimab, an immunoglobulin-like transcript 7 to target plasmacytoid dendritic cells
No difference in primary outcome... but kiiiinda looks like something there?
I dislike Phase 2's; should go straight to Phase 3 if able
#ACR24 @rheumnow Abstr#1542 https://t.co/osDWDskfnA
sheila
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The DESIR cohort of Dr. Franc et al. showed that female pts with early axSpA had significantly lower AMH levels vs. general population reflecting low ovarian reserve & fertility.
Mechanism?
Bigger studies need to be done
@RheumNow #ACR24 abs577 https://t.co/842rX79bq6
Mike Putman
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@KDAO2011 help me out here; what is the point of analyses like this?
NO difference in PROs comparing voclo vs plbo...
...but if you split by responder status its different
Prescribing the drug doesn't help PROs, but when it works it works? 🤔
#ACR @RheumNow Abstr#1538 https://t.co/339drHwUuK
Richard Conway
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This is very true. We showed a number of years ago that patients with gout have increased platelet activation at baseline, which then dramatically increases during flare. Treating gout properly may ameliorate this. #ACR24 @RheumNow https://t.co/VL8fy3ezjx https://t.co/9XdrG1NG9c
Richard Conway
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Remote monitoring SHOULD increasingly be part of our care. BUT I don't think it neccessarily will. Just like with conferences reverting to non-virtual when facilitating virtual is logical from a learning perspective. There are other limiting interests in play #ACR24 @RheumNow https://t.co/UN3jGa7jVZ
David Liew
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One situation I've seen MSK ultrasound have impact ++ in the real-world is showing patients their own RA disease activity.
Arthritis might be the invisible disease sometimes, but seeing it in full Doppler colour on screen means a lot to many.
#ACR24 MSK USS Guidance @RheumNow https://t.co/wd9s6FAfp4
David Liew
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A framework for critical conversations with patients
(because the big decisions deserve high quality counselling, otherwise the consequences are real)
#ACR24 16S17 @RheumNow https://t.co/fiwYY1DuMq
David Liew
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"Do not fear RPF." - John Stone
Retroperitoneal fibrosis certainly feels challenging at times, and radiologic features might stay even after functional improvement
but we've come a long way
(although, despite B cell depletion, there's plenty more to do)
#ACR24 16S26 @RheumNow https://t.co/2Y3buXrAFY
David Liew
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The @ACRheum RA outcome measures toolkit has all the relevant tools for measuring outcomes in rheumatoid arthritis (and exactly how to do it).
https://t.co/GZ7tZ6fNMK
Great for all US rheumatologists, but also very handy for all of us globally
#ACR24 16S30 @JYazdany @RheumNow https://t.co/MSHA353MKR
