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Moneyball Rheumatology (5.30.2025)

Jack Cush, MD

Dr. Jack Cush reviews the book/movie, "Moneyball" and a suggests moneyball strategy is needed to find next level responses for our patients.

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Belimumab in SLE with Mucocutaneous or Vasculitis Findings

Jack Cush, MD

A post hoc analysis of a belimumab (BEL) inn systemic lupus erythematosus (SLE) study showed lupus mucocutaneous and vasculitic manifestations improve with BEL and standard care.

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Dafna Gladman

50 Year Perspective on Lupus

Dafna Gladman, MD

An observational cohort study was started in Toronto by Dr. Murray Urowitz in 1970. The program was set up as a specialized clinic to provide care for patients with lupus, to study clinical laboratory correlations in the disease, and to better understand long-term outcomes of the disease. What have we learned from more than 50 years of follow-up of patients with lupus? Some of the important observations include the following.

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Genetic Link to CPPD

EurekAlert!

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent.

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2025 ACR Guideline for the Treatment of SLE

Jack Cush, MD

The ACR has released its 2025 Systemic Lupus Erythematosus (SLE) treatment guidelines and consensus-based good practice statements, applicable to children and adults with SLE. 

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pregnancy,embryo,fetal

IMPACT Study - Certolizumab Efficacy in APS Pregnancies

Jack Cush, MD

A pilot trial assessed the safety and value of tumour necrosis factor α inhibitor treatment with certolizumab in patients with high-risk pregnancies with antiphospholipid syndrome (APS).

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Diagnosing Neuropsychiatric SLE (5.23.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from RheumNow.com - including views on the vagus nerve, NPSLE and CAR-T mania.

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2025 ACR Guideline for the Treatment of SLE The ACR has released its 2025 Systemic Lupus Erythematosus (SLE) treatment guidelines and consensus-based good practice statements, applicable to children and adults with SLE. https://t.co/2NFwTllLZa https://t.co/i5Q5UfE9v3

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Dr. John Cush RheumNow ( View Tweet)
IMPACT Study - Certolizumab Efficacy in APS Pregnancies A pilot trial assessed the safety and value of tumour necrosis factor α inhibitor treatment with certolizumab in patients with high-risk pregnancies with antiphospholipid syndrome (APS). Certolizumab (CZP) was shown to https://t.co/sbXW6vNX5y
Dr. John Cush RheumNow ( View Tweet)
Steroids in Lupus Nephritis: No Free Lunch https://t.co/yPQuZcnRLH https://t.co/V8GZoslSqV

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Dr. John Cush RheumNow ( View Tweet)
NEW for #LUPUS2025—@ern_reconnet–SLICC–@SLEuroSociety expert consensus on the therapeutic management of rare systemic #lupus erythematosus manifestations https://t.co/XwAHpsho57 Free to read with registration on https://t.co/28wkm5ab69 (also free) @Lupusreference #SLE https://t.co/73K0DKTHye

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The Lancet Rheumatology TheLancetRheum ( View Tweet)
Biologics in Pregnancy Patients With Autoimmune Disease A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients https://t.co/fjtUNaYtp9
Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine for Everyone Nearly 25 years ago, while lecturing on best therapies for rheumatoid arthritis (RA), I loudly stated that hydroxychloroquine was “useless” and, deservedly, I was “boo-ed” off stage. My point then was that rheumatologists needed to be aggressive, https://t.co/qKnObzr5ib
Dr. John Cush RheumNow ( View Tweet)
Biologics in Pregnancy Patients With Autoimmune Disease A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients https://t.co/CH60gShlH0
Dr. John Cush RheumNow ( View Tweet)
Does ADDING an #immunesuppressive To #belimumab in #SLE give more benefit? ❎ NO #RWE from Spain suggests no added improvement adding IS to Belimumab Should you switch Rx then? 🤷‍♀️ @RheumNow #LUPUS2025 poster110 #ClinicalPearl https://t.co/C3ydArMx7x

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Janet Pope Janetbirdope ( View Tweet)
Treat to target 🎯 #SLE #recommendations Considerations are nuanced and Impt Lowest clinical disease activity is goal Try for remission 🎯 Get patients off #glucocorticoids If not ⬇️low dose #prednisone @RheumNow #LUPUS2025 https://t.co/HlBeh2FLxP

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Janet Pope Janetbirdope ( View Tweet)
Tocilizumab vs. Methotrexate in Rheumatoid Arthritis A large randomized rheumatoid arthritis (RA) clinical trial compared subcutaneous tocilizumab (TCZ) vs oral methotrexate (MTX) vs. the combination of subcutaneous TCZ and MTX, and showed that TCZ was superior to MTX, either https://t.co/AS8MJaujIE
Dr. John Cush RheumNow ( View Tweet)
Why follow antiDNA and complements in #lupus #nephritis #LN #LUPUS2025 panel said To detect flare ?to consider after 3 to 5 yrs of remission to taper Rx ?but not for early response to Rx Just info from the panel with my opinion salted in @RheumNow https://t.co/bFUfN0PsFF

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Janet Pope Janetbirdope ( View Tweet)
deep thoughts in #lupus Is ‘better’ the enemy of #remission? Is a complete renal response <50% at the end of contemporary #triple #therapy Something to celebrate? ▶️Yes better than old #SoC but a bit sobering We need RCTs that radically change paradigm #LUPUS2025 @RheumNow

Janet Pope Janetbirdope ( View Tweet)

‘Oranges & green vegetables’ ⬆️ #diarrhea in #MMF said Ana Malvar bad #LN outcomes if #nonadherent Good relationship with#HCP helps #adherence ✅education to help deal with side effects pts need to know Why this Rx ?how long S|E Rx #ClinicalPearl #LUPUS2025 @RheumNow https://t.co/RnFGwJSl1F

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Janet Pope Janetbirdope ( View Tweet)
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