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Skin,cancer,squamous,cell

Does Methotrexate Increase Skin Cancer Risk?

d Jack Cush, MD

There are several reports suggesting a link between methotrexate (MTX) use and certain skin cancers, yet these are confounded by a higher risk of skin cancers with inflammatory conditions like rheumatoid arthritis of which MTX is the most common treatment.

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Cutaneous.lupus.SLE.Face.dermnetnz

Deucravacitinib - Effective in Systemic Lupus Erythematosus

d Jack Cush, MD

A Phase II, multicenter study has demonstrated the efficacy and safety of deucravacitinib, an oral, selective, allosteric inhibitor of TYK2, in  adults with active systemic lupus erythematosus (SLE).

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infx.pneumonia.jpg

Serious Infection Risk in Pediatric Psoriasis with Ustekinumab, Etanercept, or Methotrexate

d Jack Cush, MD

Etanercept was FDA approved for use in pediatric psoriasis (PsO) in 2016 and ustekinumab was similarly approved  in 2020.  This comparative analysis looks at the risk of serious infections (SIE) requiring hospitalization in pediatric PSO patients treated with ustekinumab, etanercept, or

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antibody (Keep)

New 5 Peptide Autoantibody Panel Complements RA Diagnosis

d MedPage Today

Antibodies to peptides not currently used for rheumatoid arthritis (RA) diagnosis helped identify patients with untreated early disease that conventional biomarkers missed, researchers said.

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Achilles,ankle,heel

GRAPPA Recommendations for Treating Enthesitis in Psoriatic Arthritis

d Jack Cush, MD

GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes. 

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Achilles,ankle,heel

ICYMI: GRAPPA Recommendations for Treating Enthesitis in Psoriatic Arthritis

d Jack Cush, MD

GRAPPA has provided new, evidence based updates to the management of enthesitis in patients with psoriatic arthritis (PsA), affecting at least 30% of PsA patients and is associated with more severe disease, x-ray damage, and poorer outcomes. 

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ChatGPT,computer,learning

ChatGPT - A Boon or Threat to Scientific Publication?

d Jack Cush, MD

ChatGPT is a new, artificial intelligence chatbot that has dramatically changed the digital worlds of education, research, graphic design, statistics and more.

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Systemic Sclerosis cohort study of 506 SSc pts with saw 5.3 with Degos-like lesions (89% in fingers). Degos lesions more assoc w/ diffuseSSc & acro-osteolysis, digital ulcers, and calcinosis (but not renal crisis, ILD, or pulmonary HTN https://t.co/Usrfr0XcCJ https://t.co/pmwkHsaJOx

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ChatGPT - A Boom or Threat to Scientific Publication? ChatGPT is a new, AI chatbot that has dramatically changed the digital worlds of education, research, statistics and more. Recently there were reports of ChatGPT passing the LSAT, USMLE, and more. https://t.co/CZd0WjOas5 https://t.co/Nx49SqXoHG

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High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis The Annals of Internal medicine has reported the results of high-dose versus low-dose exercise therapy demonstrating no benefits from more intense exercise. https://t.co/BtqeYWKG34 https://t.co/ngyM1DshDz

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Dr. John Cush RheumNow ( View Tweet)
Multicenter study of 80 AOSD & 60 controls used to develop AOSD criteria: - 3 pts rash - 3pts fever ≥ 39C - 2 pts pharyngitis - 2 pts arthritis - 2 pts NLR ≥ 4 - 1 pt glycosyl ferritin ≤ 20% 7 pts = Dx (sens 92.5%) vs Yamaguchi(79%), Fautrel (76%) https://t.co/Amew1RHaA1 https://t.co/dnJ6zVyfOW

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Full read, solid review of Diagnosis and management of autoimmune hepatitis from BMJ https://t.co/9OdxHjXMKW https://t.co/1kuHPZBLSE

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Pregnancy & RA: metanalysis of 9 studies, 12K RA pts met vs 10 million controls. RA preg have more maternal complications (C sect OR 1.55; preeclampsia OR, 1.6; preterm OR, 1.8) & neonatal probs (low gestat wt, ICU OR 1.34, & stillbirths OR, 1.99). https://t.co/30WTMC3MKn https://t.co/VXoHesd3iT

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Dr. John Cush RheumNow ( View Tweet)
Univ of Toronto’s PsA Study looked at surgery amongst 1574 pts: 185 pts (~12%) had 379 MSK surgeries related to PsA. Signif higher rates of surgery were seen w/ #damaged joints (HR 1.03), TJC/SJC (HR 1.04), nail Dz (2.08), ^ ESR (2.37), B27+ (2.22) https://t.co/XdUJ0guwUh

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Frailty in Vasculitis Dr. Patricia Harkins sits down with Professor Sebastian Sattui to discuss Abstract 0444, Prevalence of Frailty and Associated Factors in Patients with Vasculitis, being presented on at the ACR22 Convergence. https://t.co/u0CZuEcyM9 https://t.co/JXEcSoHsA2

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New Guideline: Vaccinations OK With Few Tweaks for Rheum Patients Nearly all available vaccines can be given to people with rheumatologic diseases, according to a new, detailed guideline from the ACR. https://t.co/514mIylgzj https://t.co/9Zq9pGcujV

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Dr. John Cush RheumNow ( View Tweet)
Have a rheumatology question or case for Jack Cush? Record it here and we may feature it on an upcoming podcast. Tell us your name and where you practice rheumatology. https://t.co/TampvCiCIs https://t.co/y9FDVJoEaD

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Metanalysis of Steroid Tx & metabolic events (118 studies & 17113 pts) showed an increased risk: - hyperglycemia 10% (esp lung dz 22%) - severe hyperglyc. 5%, HTN 6%, Wt gain 13% , hyperlipid 8% - Incr risk of hyperglyc(OR 2), HTN (1.7), Wt gain (5.2) https://t.co/E54IB3YVfn https://t.co/CPzrgIgJ12

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Full read, very good review of steroids, HPA suppression, equivalents, use during surgery etc from J Endo Society. Notably literature supports continued daily GC in surgical patients, with a short course of perioperative IV GC https://t.co/jzNE5o0DBG https://t.co/6V8mhTOVTv

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Dr. John Cush RheumNow ( View Tweet)
About 1 mo ago we reported US drug makers would increase price of 350 drugs; now it seems US Pharma has raised list prices of 983 arthritis, cancer and otherdrugs by an average of 5.6% in Jan 2023; as industry faces new federal laws to control costs https://t.co/HkdDurbNrQ https://t.co/rEvmwACdfk

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