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Dr. Deanne reminds us that RA is worth preventing for many reasons. #RNL2023 @RheumNow https://t.co/va0RmdhUQR
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Kevin Deane on preclinical-RA
Very complex history on development of RA with multiple phases before detectable RA shows up in your clinic.
#RNL2023 @RheumNow https://t.co/vzQFhik0aK
Robert B Chao, MD doctorRBC ( View Tweet)
#RNL2023:
Kevin Deane: Anti-CCP positive leads to a 20-30% risk for articular clinical RA within 3-5 years
@RheumNow https://t.co/skp1K4r1hF
Eric Dein ericdeinmd ( View Tweet)
STOP-RA study on HCQ preventing RA...
HCQ did NOT prevent RA development in pre-RA pts
@RheumNow #RNL2023 https://t.co/Vv3szkqxWh
Robert B Chao, MD doctorRBC ( View Tweet)
#RNL2023 @RheumNow
Kevin Deane presents his STOP RA Trial
HCQ is safe and easy - can you use it in pre-clinical RA to prevent disease?
NO EVIDENCE of decreased progression of RA in HCQ compared to placebo https://t.co/1OSVubd9rO
Eric Dein ericdeinmd ( View Tweet)
Treatment with MTX in early CCP+ RA thought to be effective in slowing disease however StopRA study did not show a difference between HCQ and PBO in patients. We need to know more about HCQ vs MTX in this space! #RNL2023 @RheumNow https://t.co/7asmvVfXiC
Dr. Rachel Tate uptoTate ( View Tweet)
The holy grail. How to stop #rheumatoid #arthritis in at risk Pts. Who to treat, when to stop? Many RCTs but no home run-NNT is high. #MTX and a diff study #Abatacept that work while on Rx and #Rituximab, most don’t work esp after stopping Rx @kevindeane #RNL23 @RheumNow https://t.co/BkIxxS0ecn
Janet Pope Janetbirdope ( View Tweet)
Dr. Deane's current management of "pre-RA" pts
- carefully eval for synovitis
- lifestyle factors - stop smoking, diet, dental hygiene
- educate pt on ~30% risk
- annual in-person follow up
@RheumNow #RNL2023 https://t.co/Z0t0Yibyri
Robert B Chao, MD doctorRBC ( View Tweet)
How do you prevent RA in at-risk patient?
Smoking cessation! Healthy weight and exercise! Diet! Periodontal health! 🚭🏋️🥕🦷
Education & follow-up!
Not robustly proven to prevent/delay RA, but may be more important than early DMARD intervention!
Kevin Deane, MD
#RNL2023 @RheumNow
Eric Dein ericdeinmd ( View Tweet)
Natural history of RA by Kevin Deane #RLN23 @RheumNow https://t.co/ab0cafDblz
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
The amazing JAKs
The many JAK/TYK targets approved for multiple conditions
Coming soon: UPA for Crohn's - first indication for Crohn's disease
#RNL2023 @RheumNow https://t.co/Pf3gzrdyeq
Eric Dein ericdeinmd ( View Tweet)
Dr. Stanley Cohen on JAKinibs:
Very concise and informative timeline on the multiple JAKinibs approved for multiple conditions
@RheumNow #RNL2023 https://t.co/3ZZHr0akrR
Robert B Chao, MD doctorRBC ( View Tweet)
JAKi cycling, likely something we all do/consider in clinic. Dr. S. Cohen reviews the JAK-pot study which shows good, expected results between cycling in patients. #RNL2023 @RheumNow https://t.co/qBau79o0VQ
Dr. Rachel Tate uptoTate ( View Tweet)
About to get my learnin' on! #RNL2023 @RheumNow
Robert B Chao, MD doctorRBC ( View Tweet)
#RNL2023 is up and running! Join us online! @RheumNow https://t.co/AGbpEjXSh6
Dr. Rachel Tate uptoTate ( View Tweet)
Follow me today and tomorrow for @RheumNow Live 2023 Coverage!
#RheumTwitter #RNL2023 https://t.co/sS6AoF1Dij
Eric Dein ericdeinmd ( View Tweet)
QD Clinic - RheumNow Live 2023 Preview https://t.co/T8VMyrL1Qz https://t.co/E90wsaqwaY
Links:
Dr. John Cush RheumNow ( View Tweet)
A Pilot Trial of Anifrolumab in Discoid Lupus
A research report in JAMA Dermatology describes the use of the type 1 interferon receptor inhibitor anifrolumab in patients with chronic discoid lupus erythematosus (DLE).
https://t.co/sax8iHuljb https://t.co/71zqAzZViV
Links:
Dr. John Cush RheumNow ( View Tweet)
Itaconate - A Potential New Immunosuppressive
Researchers have revealed the modulatory effect of the anti-inflammatory metabolite ITA on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.
https://t.co/1kaxHou8pz https://t.co/VLLAzgiYoM
Links:
Dr. John Cush RheumNow ( View Tweet)
Happy Match Day! Congratulations to all that have matched. #MATCHDAY2023
Dr. John Cush RheumNow ( View Tweet)