DSB Reports & Updates - January 2016

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Comparative Harmful Risks with Targeted Immunomodulators. Desai et al did a systematic review of the literature, findings of 10 head-to-head RCTs and 51 observational studies.

Exercise Benefits Osteoarthritis Hip Pain

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(Reuters Health) - Water- or land-based exercise should provide some short-term benefit in pain management for hip osteoarthritis, though there are few well-designed trials testing it, according to a new review published in the British Journal of Sports Medicine.

UCSF Study Shows Weight Loss Protects OA Cartilage

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Researchers at the University of California at San Francisco have shown that >10% weight loss may impact the rate of cartilage loss as determined by MRI scanning.  They presented their findings yesterday at the annual meeting of the Radiological Society of North America (RSNA). 

SB4 - A Second Biosimilar Up For Review in Europe

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A biosimilar of etanercept (Enbrel) made by the South Korean company Samsung Bioepis is under consideration by regulators in the European Union. Samsung Bioepis, a joint venture between Samsung Biologics and Biogen, is taking aim with its version of etanercept.

Biology of Bone Remodeling in Psoriatic Disease

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Paine and Ritchlin have reviewed the evidence that new bone formation is centered around enthesial sites and that such findings are evident in psoriatic arthritis as well as psoriasis patients without arthritis.

Hip Fracture Risk Factors in the Elderly

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As risk of hip fracture increases with advanced age, our knowledge of risk factors for hip fracture among very old people remains limited.

Knee OA (not Hand) is Associated with Higher Mortality in Women

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"Doc....the pain is killing me."

This oft heard patient complaint may be truer than you think.

Increasing Risk of Septic Arthritis with Age

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A retrospective population-based study from New Zealand examined the epidemiology, clinical features, and microbiology of adult native joint septic arthritis.

Vertebral Fractures in 10% of Spondyloarthritis Patients

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Vertebral fractures are not uncommon in patients with ankylosing spondylitis and spondyloarthritis.

Physical Therapy Has Modest Effects on Acute Low Back Pain

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A new JAMA study shows new onset back pain treated with physical therapy yields modest short-term (3 months) improvement. 

Prescription Opioid Use Falls While Abuse Rises

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From 2003 to 2013, the percentage of nonmedical use of prescription opioids decreased among adults in the U.S., while the prevalence of prescription opioid use disorders, frequency of use, and related deaths increased, according to a study in the October 13 issue of JAMA.

Circadian Efficacy with Cathepsin K Inhibitor ONO-5334

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Osteoporosis is associated with significant morbidity, and hip fractures as sequelae confer a 1-year mortality risk of 8.4–36%.

Increasing Numbers of Knee Replacements

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Knee replacement surgery is on the rise, and so is the cost.

Prolonged Breastfeeding Associated with Postmenopausal Osteoporosis

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The effects of prior breastfeeding on bone density of postmenopausal women have been controversial. Several studies suggest that breastfeeding and childbirth lead to maternal calcium loss and a decline in bone mineral density (BMD).

A Controlled Trial of Yoga Benefits Arthritis Patients

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Yoga and stretching appear to be important forms of exercise for patients with fibromyalgia, but their utility has seldom been explored in patients with rheumatoid or osteoarthritis.

Age and Comorbidity Contribute to Higher Death Risk Following Hip Fracture Surgery

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Patients undergoing surgery for a hip fracture appear to have higher death rates than those having elective total hip replacement.

Overuse and Underuse of Osteoporosis Drugs

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A population-based sudy 824 post-menopausal women ≥50 years old from Valencia, Spain was studied to estimate the percentage of women eligible for treatment, and the proportion of overuse and underuse of antiosteoporotic treatment according to highly-influentia

A Rule of Five Spots Spine Disease

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A combined rule of five -- the presence of at least five fatty lesions/erosions in the sacroiliac (SI) joint, at least five fatty lesions in the spine, or at least five spinal inflammatory lesions on magnetic resonance imaging (MRI) -- is highly specific for axial spondyloarthritis in patients wi

Romosozumab Surpasses Teraparitide in the STRUCTURE Study

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The experimental bone drug, romosozumab, has succeeded in meeting its primary endpoint by showing it was significantly more effective than teriparatide in a 12-month study assessing total hip bone density in postmenopausal women with osteoporosis.  

Bicycle Injuries and Fatalities Increasing in Older Americans

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JAMA reports the number of traumatic injuries related to bikes in adults nearly doubled from 1998 to 2013 -- going from 8,791 to 15,427. The researchers used data from the National Electronic Injury Surveillance System, which includes data from of 100 emergency departments, and U.S.