Subclinical Synovitis in Psoriasis Portends Future Psoriatic Arthritis Save
It is estimated that nearly 30% of psoriasis patients will develop psoriatic arthritis (PsA). This prevalence was studied by performing MRI scans on asymptomatic psoriasis (n=56) and 30 control patients without arthritis.
MRI of the hands were scored for synovitis, osteitis, tenosynovitis and periarticular inflammation. Psoriasis patients underwent quantitative CT to detect erosions and enthesitis.
Nearly half (47%) of psoriasis patients had at least one inflammatory lesion on MRI, with synovitis being the most prevalent inflammatory lesion (38%), followed by osteitis (11%), tenosynovitis (4%) and periarticular inflammation (4%). The risk for developing PsA was as high as 60% if patients had subclinical synovitis and arthralgia, but only 13% in those without either.
Subclinical joint inflammation exists in a subset of psoriasis, indicating a preclinical state identifying those at high-risk for the development of PsA.
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